1. CORESTA Congress, Quebec, 2014, Smoke Science/Product Technology Groups, ST 54

    Indoor air chemistry (IAC): comparative study between conventional cigarette and heat-not-burn technology

    GOUJON C.; MAEDER S.
    Philip Morris International R&D, Neuchâtel, Switzerland
    Philip Morris International (PMI) is developing products with the potential to reduce the risk associated with smoking. The Electrically Heated Tobacco System (EHTS) operates by heating a tobacco stick with a holder at a controlled temperature. By...
  2. CORESTA Congress, Quebec, 2014, Smoke Science/Product Technology Groups, ST 78

    Predictability of in vitro toxicological assessments of cigarettes: analysis of seven years of regulatory submissions to Canadian authorities

    BELUSHKIN M.(1); PIADÉ J-J.(1); CHAPMAN S.(2); FAZEKAS G.(2)
    (1) Philip Morris International R&D, Philip Morris Products S.A., Neuchâtel, Switzerland; (2) Rothmans, Benson & Hedges Inc., Brampton, Ontario, Canada
    Canadian authorities have required the annual submission of a wealth of by-brand information about cigarettes – including analytical data for cut filler and mainstream smoke constituents, for more than a decade. In 2005, the reporting requirements...
  3. CORESTA Congress, Quebec, 2014, Smoke Science/Product Technology Groups, ST 85

    Highly time-resolved two-dimensional mapping of molecular combustion and pyrolysis product concentrations: looking into a burning cigarette during puffing

    ZIMMERMANN R.(1); HERTZ-SCHÜNEMANN R.(1); EHLERT S.(1); LIU C.(2); McADAM K.G.(2); BAKER R.R.(2)†; COBURN S.(2); STREIBEL T.(1)
    (1) University of Rostock, Chair of Analytical Chemistry, Rostock, Germany; (2) British American Tobacco, Group R&D, Southampton, U.K.; (†) Deceased
    Combustion and pyrolysis are complex and dynamic chemical processes that are by far not fully understood. This is in particular true when the highly dynamic cigarettes smoking process is considered. The gas phase chemistry of tobacco combustion in...
  4. CORESTA Congress, Quebec, 2014, Smoke Science/Product Technology Groups, STPOST 21

    Evaluating the genotoxicity of tobacco smoke-derived aerosols using the flow cytometry-based in vitro micronucleus assay

    POULEAU B.; SMART D.J.; McHUGH D.
    Philip Morris International R&D, Philip Morris Products S.A., Neuchâtel, Switzerland
    The in vitro micronucleus (MN) assay is used to assess the genotoxic potential of a test substance by measuring the induction of micronuclei in cultured mammalian cells. The flow cytometry-based assay (in vitro MicroFlow® kit, Litron Laboratories,...
  5. CORESTA Congress, Quebec, 2014, Smoke Science/Product Technology Groups, STPOST 23

    Quantitative evaluation of the mutagenicity induced by tobacco smoke-derived total particulate matter using the mouse lymphoma assay

    DEMOUTE A-L.; AL-JOBORI O.; POULEAU B.; SMART D.J.; McHUGH D.
    Philip Morris International R&D, Philip Morris Products S.A., Neuchâtel, Switzerland
    The mouse lymphoma assay (MLA) is a regulatory in vitro test deployed to evaluate the mutagenicity of a test substance via exposure of the thymidine kinase locus in L5178Y mouse lymphoma cells. As part of a proficiency study, we evaluated the...
  6. TSRC, Tob. Sci. Res. Conf., 2014, 68, abstr. 41

    Highly time-resolved two-dimensional mapping of the molecular combustion and pyrolysis product concentrations during a puff in a burning cigarette

    ZIMMERMANN R.(1); HERTZ-SCHÜNEMANN R.(1); STREIBEL T.(1); EHLERT S.(2); WALTE A.(2); LIU C.(3); McADAM K.(3)
    (1) University of Rostock, Rostock, Germany; (2) Photonion GmbH, Schwerin, Germany; (3) British American Tobacco, Southampton, UK
    Cigarette smoking is an extremely complex and dynamic chemical process. The gas phase chemistry of tobacco combustion in the tobacco voids and pores is difficult to address by conventional analytical methods. Recently photo ionisation mass...
  7. TSRC, Tob. Sci. Res. Conf., 2014, 68, abstr. 70

    On-line photo ionization mass spectrometry for characterization of smoke from e-cigarettes or heat-not-burn devices

    ZIMMERMANN R.(1); STREIBEL T.(1); HEIDE J.(1); HERTZ-SCHÜNEMANN R.(1); EHLERT S.(2); WALTE A.(2); LIU C.(3); McADAM K.(3)
    (1) University of Rostock, Rostock, Germany; (2) Photonion GmbH, Schwerin, Germany; (3) British American Tobacco, Southampton, UK
    Photoionization time of flight mass spectrometry (PI-TOFMS) is well suited for on-line characterization of tobacco smoke. Depending on the photoionization method (single photon ionization, SPI or resonance-enhanced multiphoton ionization, REMPI),...