1. CORESTA Congress, Quebec, 2014, Smoke Science/Product Technology Groups, ST 45

    Comprehensive analysis of lipid compounds in tobacco leaf

    MASUGI E.(1); DUNKLE M.(2); t'KINT R.(2); MITSUI M.(1); OCHIAI N.(3); DAVID F.(2); SANDRA K.(2); SANDRA P.(2)
    (1) Japan Tobacco Inc. Tobacco Science Research Center, Yokohama, Kanagawa, Japan; (2) Research Institute for Chromatography, Kortrijk, Belgium; (3) GERSTEL K.K., Tokyo, Japan
    In recent years, lipidomics has been a vastly expanding field of research due to the development of new technologies in liquid chromatography and from recognising the role of lipids in metabolism. Tobacco leaf consists of thousands of chemical...
  2. CORESTA Congress, Quebec, 2014, Smoke Science/Product Technology Groups, ST 54

    Indoor air chemistry (IAC): comparative study between conventional cigarette and heat-not-burn technology

    GOUJON C.; MAEDER S.
    Philip Morris International R&D, Neuchâtel, Switzerland
    Philip Morris International (PMI) is developing products with the potential to reduce the risk associated with smoking. The Electrically Heated Tobacco System (EHTS) operates by heating a tobacco stick with a holder at a controlled temperature. By...
  3. CORESTA Congress, Quebec, 2014, Smoke Science/Product Technology Groups, ST 78

    Predictability of in vitro toxicological assessments of cigarettes: analysis of seven years of regulatory submissions to Canadian authorities

    BELUSHKIN M.(1); PIADÉ J-J.(1); CHAPMAN S.(2); FAZEKAS G.(2)
    (1) Philip Morris International R&D, Philip Morris Products S.A., Neuchâtel, Switzerland; (2) Rothmans, Benson & Hedges Inc., Brampton, Ontario, Canada
    Canadian authorities have required the annual submission of a wealth of by-brand information about cigarettes – including analytical data for cut filler and mainstream smoke constituents, for more than a decade. In 2005, the reporting requirements...
  4. CORESTA Congress, Quebec, 2014, Smoke Science/Product Technology Groups, STPOST 21

    Evaluating the genotoxicity of tobacco smoke-derived aerosols using the flow cytometry-based in vitro micronucleus assay

    POULEAU B.; SMART D.J.; McHUGH D.
    Philip Morris International R&D, Philip Morris Products S.A., Neuchâtel, Switzerland
    The in vitro micronucleus (MN) assay is used to assess the genotoxic potential of a test substance by measuring the induction of micronuclei in cultured mammalian cells. The flow cytometry-based assay (in vitro MicroFlow® kit, Litron Laboratories,...
  5. CORESTA Congress, Quebec, 2014, Smoke Science/Product Technology Groups, STPOST 23

    Quantitative evaluation of the mutagenicity induced by tobacco smoke-derived total particulate matter using the mouse lymphoma assay

    DEMOUTE A-L.; AL-JOBORI O.; POULEAU B.; SMART D.J.; McHUGH D.
    Philip Morris International R&D, Philip Morris Products S.A., Neuchâtel, Switzerland
    The mouse lymphoma assay (MLA) is a regulatory in vitro test deployed to evaluate the mutagenicity of a test substance via exposure of the thymidine kinase locus in L5178Y mouse lymphoma cells. As part of a proficiency study, we evaluated the...