1. CORESTA Congress, Kunming, 2018, Agronomy/Phytopathology Groups, AP 10

    Testing performance of tobacco varieties in water stress conditions

    CAMPANONI P.(1); LAPARRA H.(1); OZELLEY P.(1); DELLA CIANA P.(3); BISCARINI E.(3); MAURIZI L.(2); NARDONI N.(2); TRIPPELLA C.(2); GOEPFERT S.(1)
    (1) Philip Morris Products S.A. (part of Philip Morris International group of companies), PMI R&D, Neuchâtel, Switzerland; (2) Philip Morris Italia s.r.l., via Po 11-13-15, 00198, Roma, Italy; (3) L’Agricola s.r.l., Bastia Umbra, Perugia, Italy
    Increasing climate instability could lead to local agricultural constraints, presenting a risk for volumes and quality of tobacco supply. Selecting and breeding tobacco varieties for the ability to perform in unfavourable water conditions becomes a ...
  2. CORESTA Congress, Kunming, 2018, Agronomy/Phytopathology Groups, AP 24

    Downregulation of a putative nitrate transporter gene substantially reduces the accumulation of TSNAs in air-cured tobaccos

    GOEPFERT S.(1); BOVET L.(1); LU J.(2); CAMPANONI P.(1); LEWIS R.S.(2); DEWEY R.E.(2)
    (1) Philip Morris Products S.A. (part of Philip Morris International group of companies), PMI R&D, Neuchâtel, Switzerland; (2) North Carolina State University, Department of Crop Science, Raleigh, NC, U.S.A.
    Air-cured Burley tobacco leaves typically exhibit high levels of nicotine-derived nitrosamine ketone (NNK) and N'-nitrosonornicotine (NNN). It has been previously demonstrated that leaf nitrate accumulation in air-cured tobaccos serves as the source ...
  3. CORESTA Congress, Kunming, 2018, Agronomy/Phytopathology Groups, AP 49

    The influence of Nicotiana alata-derived introgression on plant malformations of tobacco breeding lines resistant to tomato spotted wilt virus

    KORBECKA-GLINKA G.(1); TROJAK-GOLUCH A.(1); DOROSZEWSKA T.(1); GOEPFERT S.(2)
    (1) Institute of Soil Science and Plant Cultivation - State Research Institute, Pulawy, Poland; (2) Philip Morris Products S.A. (part of Philip Morris International group of companies), PMI R&D, Neuchâtel, Switzerland
    Tomato spotted wilt virus (TSWV) is one of the most destructive viruses for tobacco cultivation. Cultivar “Polalta” carries a resistance gene introgressed from a wild species, Nicotiana alata, but the use of this cultivar in breeding is hampered by ...
  4. CORESTA Congress, Kunming, 2018, Smoke Science/Product Technology Groups, ST 04

    Assessing the cytotoxicity of e-liquids without the use of the neutral red uptake assay

    McHUGH D.; CUDAZZO G.; VANSCHEEUWIJCK P.
    Philip Morris Products S.A. (part of Philip Morris International group of companies), PMI R&D, Neuchâtel, Switzerland
    As part of the pre-clinical assessment performed for consumer products in the tobacco industry, an in vitro assessment of a tobacco product’s cytotoxicity was performed using the neutral red uptake (NRU) assay. Since 2004, the CORESTA In Vitro Task Force ...
  5. CORESTA Congress, Kunming, 2018, Smoke Science/Product Technology Groups, STPOST 01

    Cross-sectional surveys on the use of tobacco products in the general population and in users of IQOS in Germany, Italy, and London (2018-2020): introducing the study protocols

    SPONSIELLO-WANG Z.; LANGER P.; PRIETO L.; DOBRYNINA M.; SKIADA D.; CAMILLE N.; WEITKUNAT R.; LÜDICKE F.
    Philip Morris Products S.A. (part of Philip Morris International group of companies), PMI R&D, Neuchâtel, Switzerland
    Background: Philip Morris International (PMI) launched cross-sectional surveys in Italy, Germany, and London in March 2018 following the commercialization of a heat-not-burn tobacco product, IQOS. This publication introduces the study protocols. Methods: ...
  6. CORESTA Congress, Kunming, 2018, Smoke Science/Product Technology Groups, STPOST 02

    Quantification of nitrogen oxides in aerosol of heat-not-burn IQOS product and combination of aerosol collection with the aerosol generation for TSNA analysis

    BADER P.; DEBRICK A.; GAUTIER L.; RADTKE F.; HUNKELER P.; MATERA R.; REYREN C.; CRENNA M.; STOOP A.
    Philip Morris Products S.A. (part of Philip Morris International group of companies), PMI R&D, Neuchâtel, Switzerland
    Nitrogen oxides (NOx), nitrogen monoxide (NO), and tobacco-specific nitrosamines (TSNA) are compounds that are analysed in the mainstream aerosol of heat-not-burn tobacco products, such as IQOS. The purpose of this study was to develop and validate a ...
  7. CORESTA Congress, Kunming, 2018, Smoke Science/Product Technology Groups, STPOST 03

    Determination of nicotine, eugenol, menthol and aerosol formers in tobacco products and materials

    BELLO J.; D’AGOSTINO A.; JUVET-PECALVEL C.; NAGANATHAN K.; ROTA C.; GAUTIER L.; O’REILLY C.; DUPASQUIER N.; YERLY M.
    Philip Morris Products S.A. (part of Philip Morris International group of companies), PMI R&D, Neuchâtel, Switzerland
    The purpose of this study was to validate a unique method that simultaneously determines the concentration of nicotine, eugenol, menthol, and glycerin in Reduced-Risk Products tobacco products [1], and menthol and triacetin in materials. Analytes are ...
  8. CORESTA Congress, Kunming, 2018, Smoke Science/Product Technology Groups, STPOST 30

    Effects of exposure to e-cigarette aerosols compared with cigarette smoke on 3D human buccal and small airway cultures: a systems toxicology assessment

    ISKANDER A.(1); STEINER S.(1); MAJEED S.(1); KONDYLIS A.(1); XIANG Yang(1); ZANETTI F.(1); FRENTZEL S.(1); MARTIN F.(1); PEITSCH M.C.(1); DOSHI U.(2); McKINNEY W.J.(2); LEE K.M.(2); HOENG J.(1)
    (1) Philip Morris Products S.A. (part of Philip Morris International group of companies), PMI R&D, Neuchâtel, Switzerland; (2) Altria Client Services LLC, Research, Development & Regulatory Affairs, Richmond VA, U.S.A.
    Considerable attention has been given toward the reduced risk potential of e-cigarettes (e-cigs). Most in vitro studies have focused on testing e-liquid formulations directly on submerged 2D cultures. Here, we examined the effects of exposure to the whole ...