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286 results

  1. CORESTA Congress, Online, 2020, Smoke Science/Product Technology Groups, ST 17

    The dos and don’ts of non-targeted screening by LC–HRAM-MS for chemical characterization of smoke-free products

    WACHSMUTH C.; ARNDT D.; BUCHHOLZ C.; BENTLEY M.; GOUJON-GINGLINGER C.
    Philip Morris Products S.A., PMI R&D, Neuchâtel, Switzerland
    Liquid chromatography coupled to high-resolution accurate-mass spectrometry (LC–HRAM-MS)-based non-targeted screening (NTS) is a key methodology for characterizing the chemical composition of complex matrices. It enables simultaneous identification...
  2. CORESTA Congress, Online, 2020, Smoke Science/Product Technology Groups, ST 18

    Computer-assisted structure identification (CASI) for high-throughput identification of small molecules by GC×GC–HRAM-TOFMS

    KNORR A.; ALMSTETTER M.; MARTIN E.; CASTELLON A.; POSPISIL P.; BENTLEY M.; GOUJON C.
    Philip Morris Products S.A., PMI R&D, Neuchâtel, Switzerland
    Compound identification is widely recognized as a major bottleneck in modern metabolomic approaches and high-throughput non-targeted characterization of complex matrices. An automated platform CASI (computer-assisted structure identification) was...
  3. CORESTA Congress, Online, 2020, Smoke Science/Product Technology Groups, ST 19

    Non-targeted chemical characterization of complex matrices by nominal- and high-resolution accurate-mass GC×GC–TOFMS

    ALMSTETTER M.; KNORR A.; RHOUMA M.; MARTIN E.; CASTELLON A.; POSPISIL P.; BENTLEY M.; GOUJON C.
    Philip Morris Products S.A., PMI R&D, Neuchâtel, Switzerland
    Comprehensive chemical characterization is an important element in the development of heat-not-burn products. Beyond the challenge of developing powerful analytical methods with sufficient chromatographic and spectral resolution, it is essential to...
  4. CORESTA Congress, Online, 2020, Smoke Science/Product Technology Groups, ST 21

    Untargeted chemical characterization of the aerosol generated by a heated tobacco product

    BENTLEY M.; ALMSTETTER M.; ARNDT D.; KNORR A.; MARTIN E.; POSPISIL P.; MAEDER S.
    Philip Morris Products S.A., PMI R&D, Neuchâtel, Switzerland
    In contrast to quantitative analysis, where chemical constituents of interest are targeted to the exclusion of all others, an untargeted approach considers indiscriminate determination of all analytes relevant to a specific chemical space. A...
  5. CORESTA Congress, Online, 2020, Smoke Science/Product Technology Groups, ST 24

    Dos and don’ts in the design of indoor air quality studies on smoke-free products

    MITOVA M.I.; GOUJON-GINGLINGER C.; GOMEZ LUESO M.; ROTACH M.; MAEDER S.
    Philip Morris Products S.A., PMI R&D, Neuchâtel, Switzerland
    Indoor air quality (IAQ) studies on smoke-free products (SFPs), such as electrically heated tobacco products (EHTPs) and e-vapour products (EVPs), have demonstrated substantial reduction of environmental emissions relative to cigarette smoking. IAQ...
  6. CORESTA Congress, Online, 2020, Smoke Science/Product Technology Groups, ST 26

    Comparative risk assessment of heated tobacco product and electronic cigarette aerosols with cigarette smoke based on cancer potency and margin of exposure

    RODRIGO G.; JACCARD G.; TAFIN DJOKO D.; KORNELIOU A.; ESPOSITO M.; BELUSHKIN M.
    Philip Morris Products S.A., PMI R&D, Neuchâtel, Switzerland
    An average reduction of more than 90 % in concentrations of harmful and potentially harmful constituents (HPHCs; among given lists) has been observed in the aerosols of commercial heated tobacco products (HTPs) and electronic cigarettes (ECs)...
  7. CORESTA Congress, Online, 2020, Smoke Science/Product Technology Groups, STPOST 05

    A screening method by gas chromatography–mass spectrometry for the quantitation of 33 aerosol constituents from a heat-not-burn tobacco product

    HOFER I.; GAUTIER L.; CORTES SAUTEUR E.; DOBLER M.; PYTHON A.; O’REILLY C.; GISI D.; TINGUELY E.; WEHREN L.; GARCÍA FIDALGO E.; CUKURCAM L.; HENNEMANN M.; MATERA R.; ROTA D.; SANTOS CH.; SEQUEIRA C.; EPARS T.
    Philip Morris Products S.A., PMI R&D, Neuchatel, Switzerland
    This screening method allows the quantitation of 33 compounds [phenol, o-cresol, m-cresol, p-cresol, catechol, resorcinol, hydroquinone, 1,3-butadiene, isoprene, benzene, acrylonitrile, toluene, pyridine, styrene, propylene glycol, menthol,...
  8. CROM Symposium, Online, 2020, CROM 01

    A consortium approach for consumer-reported outcome measures for assessing tobacco and nicotine-containing products

    ACQUADRO C.(1); AFOLALU E.F.(2); BLACK R.A.(3); CAHOURS X.(4); CHREA C.(2); CLERC E.(2); CURTIN G.(5); EVANS S.(6); GILES L.(7); MacCAFFREY S.(3); PARK H.(8); PRASAD K.(9); SARKAR M.(10); SHIFFMAN S.(11); WEI Lay(10)
    (1) ICON PLC, Lyon, France; (2) Philip Morris Products SA, Switzerland; (3) JUUL Labs, Inc., USA; (4) Imperial Brands, France; (5) RAI Services Company, USA; (6) Turning Point Brands, USA; (7) JT International SA, Switzerland; (8) KT&G Research Institute, Republic of Korea; (9) British American Tobacco, U.K.; (10) Altria Client Services, USA; (11) Pinney Associates, USA
    The continuum of risk of tobacco products is generally accepted among public health authorities, where combustible products like cigarettes are the most risky and noncombustible products are at the lower end of the continuum. Adult smokers (AS)...
  9. CROM Symposium, Online, 2020, CROM 03

    Use of qualitative research to ensure we measure what matters to users of tobacco and/or nicotine products

    AFOLALU E.F.(1); CLERC E.(1); ABETZ-WEBB L.(2); CHREA C.(1)
    (1) Philip Morris Products SA, Neuchatel, Switzerland; (2) Patient-Centered Outcomes Assessments, Ltd, Cheshire, UK
    Cigarette smoking has a profound impact not on only physiological health but also perceived health and quality of life. There is currently a public health focus on cigarette smokers who switch to alternative smoke-free tobacco and nicotine-containing...
  10. CROM Symposium, Online, 2020, CROM 05

    Establishing traceability of self-reported dependence measurement through the use of crosswalks

    SALZBERGER T.(1); CANO S.(2); ABETZ-WEBB L.(3); AFOLALU E.F.(4); CHREA C.(4); WEITKUNAT R.(4); ROSE J.(6)
    (1) WU Wien (University of Economics and Business), Institute for Statistics and Mathematics, Austria; (2) Modus Outcomes, UK; (3) Patient-Centered Outcomes Assessments, UK; (4) PMI R&D, Philip Morris Products S.A., Switzerland; (6) Rose Research Center, LLC, USA
    Measurement in the social sciences has been characterized by deficient justification and underdeveloped conceptual theories. Instruments supposed to measure the same measurand typically do not provide comparable measurements. From the perspective of...