1. CORESTA Congress, Kunming, 2018, Agronomy/Phytopathology Groups, AP 24

    Downregulation of a putative nitrate transporter gene substantially reduces the accumulation of TSNAs in air-cured tobaccos

    GOEPFERT S.(1); BOVET L.(1); LU J.(2); CAMPANONI P.(1); LEWIS R.S.(2); DEWEY R.E.(2)
    (1) Philip Morris Products S.A. (part of Philip Morris International group of companies), PMI R&D, Neuchâtel, Switzerland; (2) North Carolina State University, Department of Crop Science, Raleigh, NC, U.S.A.
    Air-cured Burley tobacco leaves typically exhibit high levels of nicotine-derived nitrosamine ketone (NNK) and N'-nitrosonornicotine (NNN). It has been previously demonstrated that leaf nitrate accumulation in air-cured tobaccos serves as the source ...
  2. CORESTA Congress, Kunming, 2018, Smoke Science/Product Technology Groups, STPOST 30

    Effects of exposure to e-cigarette aerosols compared with cigarette smoke on 3D human buccal and small airway cultures: a systems toxicology assessment

    ISKANDER A.(1); STEINER S.(1); MAJEED S.(1); KONDYLIS A.(1); XIANG Yang(1); ZANETTI F.(1); FRENTZEL S.(1); MARTIN F.(1); PEITSCH M.C.(1); DOSHI U.(2); McKINNEY W.J.(2); LEE K.M.(2); HOENG J.(1)
    (1) Philip Morris Products S.A. (part of Philip Morris International group of companies), PMI R&D, Neuchâtel, Switzerland; (2) Altria Client Services LLC, Research, Development & Regulatory Affairs, Richmond VA, U.S.A.
    Considerable attention has been given toward the reduced risk potential of e-cigarettes (e-cigs). Most in vitro studies have focused on testing e-liquid formulations directly on submerged 2D cultures. Here, we examined the effects of exposure to the whole ...
  3. CORESTA Congress, Kunming, 2018, Smoke Science/Product Technology Groups, STPOST 58

    Developing fit-for-purpose self-report instruments for assessing consumer responses to tobacco and nicotine products: the ABOUT Toolbox initiative

    CHREA C.(1); SPIES E.(1); AFOLALU E.F.(1); MAINY N.(1); GALLOT S.(1); BINGGELI P.(1); CLERC E.(1); WEITKUNAT R.(1); SALZBERGER T.(2); CANO S.(3); ACQUADRO C.(4); ARNOULD B.(4); LAMBERT J.(4); BRUNEL V.(4); MARCUCCILLI C.(4); ABETZ-WEBB L.(5); ROSE J.(5); FAGERSTRÖM K.(5)
    (1) Philip Morris Products S.A.(part of Philip Morris International group of companies), Neuchâtel, Switzerland; (2) University of Economics and Business, Vienna, Austria; (3) ScaleReport, Ltd, Stotfold, U.K.; (4) Mapi, an ICON plc Company, Lyon, France; (5) Patient-Centered Outcomes Assessments, Ltd, Macclesfield, Cheshire, U.K.; (6) Rose Research Center, Raleigh, NC, U.S.A.; (7) K. Fagerström Consulting AB, Vaxholm, Sweden
    Assessing the full potential of reduced risk products (RRP), for individual users and the population as a whole, requires the assessment of consumer perception and behavior associated with tobacco and nicotine products (TNP) with different exposure and ...
  4. CORESTA Congress, Kunming, 2018, Smoke Science/Product Technology Groups, STPOST 61

    A 6-month inhalation study in Apoe-/- mice to investigate cardiovascular and respiratory exposure effects of e-vapor aerosols compared with cigarette smoke

    WONG Ee Tsin(1); SZOSTAK J.(2); KRISHNAN S.(1); TAN Wei Teck(1); SEOW E.(1); TENG C.(1); LEE K.M.(3); ZHANG Jingjie(3); McKINNEY W.J.(3); PEITSCH M.C.(2); VANSCHEEUWIJCK P.(2); HOENG J.(2)
    (1) Philip Morris International Research Laboratories Pte. Ltd., (part of Philip Morris International group of companies), PMI R&D, Singapore; (2) Philip Morris Products S.A. (part of Philip Morris International group of companies), PMI R&D, Neuchâtel, Switzerland; (3) Altria Client Services LLC, Richmond, VA, U.S.A.
    Chronic exposure to cigarette smoke is a risk factor for the development and progression of cardiovascular disease and chronic obstructive pulmonary disease. Considerable attention has been given towards the potential reduced harm of e cigarettes (e cigs) ...
  5. CORESTA Meeting, Smoke Science/Product Technology, 2017, Kitzbühel, ST 63 (also presented at TSRC 2017)

    A computational model to characterize the Vitrocell® Cell Exposure System for evaluation of aerosols

    CASTRO N.(1); ROSTAMI A.(1); KUCZAJ A.(2,3); LUCCI F.(2); OLDHAM M.J.(1); PITHAWALLA Y.B.(1)
    (1) Altria Client Services LLC, Center for Research and Technology, Richmond, VA, U.S.A.; (2) Philip Morris Products S.A. (part of Philip Morris International group of companies), PMI R&D, Neuchâtel, Switzerland; (3) Multiscale Modeling and Simulation, Faculty EEMCS, University of Twente, Enschede, The Netherlands
    In vitro exposure systems can be used as tools for toxicological assessment of e-cigarette aerosols. The VITROCELL ® exposure system is designed such that exposure of cell cultures to the aerosol occurs at the air/liquid interface, which is relevant to e ...
  6. CORESTA Meeting, Smoke Science/Product Technology, 2017, Kitzbühel, STPOST 26

    How do consumers use the candidate modified risk tobacco product (MRTP) tobacco heating system (THS): analysis of data from six countries

    ROULET S.(1); MAGNANI P.(1); KALLISCHNIGG G.(2); BADOGLIO S.(1); ACKERMANN K.(3); VEIT M.(3); DUGAN A.(4); GAGE C.(4); KANITSCHEIDER C.(5); APECECHEA M.(5); RAMAZZOTTI A.(1)
    (1) Philip Morris International Management S.A. (PMI), Lausanne, Switzerland; (2) ARGUS – Statistics and Information Systems in Environment and Public Health, Berlin, Germany; (3) FehrAdvice & Partners, Zurich, Switzerland; (4) Kantar Health LLC, New York, U.S.A.; (5) Kantar Health GmbH, Munich, Germany
    PMI conducted consumer studies in several countries for a candidate MRTP, the THS. THS is composed of a tobacco heating device which heats specially designed tobacco sticks. The purpose of these studies was to investigate how adult daily smokers actually ...
  7. CORESTA Meeting, Smoke Science/Product Technology, 2017, Kitzbühel, STPOST 31

    Psychometric evaluation of the mCEQ applied to cigarettes and heat-not-burn products in the U.S. and Japan

    SALZBERGER T.(1); CANO S.(2); MAINY N.(3); CHREA C.(3); VANDYKE S.(3); HAZIZA C.(3); WEITKUNAT R.(3); ROSE J.(4)
    (1) University of Economics and Business, Vienna, Austria; (2) Scale Report, Stotfold, U.K.; (3) Philip Morris Products S.A., Neuchatel, Switzerland; (4) Rose Research Center, Raleigh, U.S.A.
    The modified Cigarette Evaluation Questionnaire (mCEQ) is a self-report instrument that assesses the reinforcing effects of smoking cigarettes from a smoker’s perspective. Conceptually, the mCEQ consists of three multi-item and two single-item domains. ...
  8. TSRC, Tob. Sci. Res. Conf., 2017, 71, abstr. 129 (also presented at CORESTA SSPT2017)

    A computational model to characterize the Vitrocell® cell exposure system for evaluation of aerosols

    CASTRO N.(1); ROSTAMI A.A.(1); OLDHAM M.J.(1); PITHAWALLA Y.B.(1); LUCCI F.(2); KUCZAJ A.(2)
    (1) Altria Client Services, Richmond, VA, USA; (2) Philip Morris International, Neuchâtel, Switzerland
    In vitro exposure systems can be used as tools for toxicological assessment of e-cigarette aerosols. The VITROCELL® exposure system is designed such that exposure of cell cultures to the aerosol occurs at the air/liquid interface, which is relevant to e ...
  9. 47th TWC, Tob. Work. Conf., 2016, abstr. 29

    Working towards an increased understanding of the genetics of soil-borne disease resistance in tobacco

    DRAKE K.(1); LEWIS R.S.(1); BAKAHER N.(2); GOEPFERT S.(2); PHILIPPON B.(2); MARK R.(2); PETERSON P.D.(3)
    (1) North Carolina State University, Raleigh NC USA; (2) Philip Morris International, Neuchatel, Switzerland; (3) Clemson University, Florence SC USA
    Black shank and bacterial wilt, caused by Phytophthora nicotianae and Ralstonia solanacearum, respectively, are the most important diseases affecting tobacco production in the United States. An increased understanding of the genetic systems controlling ...