1. Tobacco Science & Technology, 2012, 2, p. 43-46., ISSN.1002-0861

    Determination of NNN and its metabolites in rabbit blood with HPLC-MS/MS

    ZHAO Beibei(1); WANG Sheng(1); WANG Juan(2); WANG Zhaoyu(3); ZHANG Jianxun(1)
    (1) Zhengzhou Tobacco Research Institute of CNTC, Zhengzhou 450001, P.R. China; (2) Quality Supervision & Test Station of Hainan Tobacco Corporation, Haikou 571100, P.R. China; (3) Quality Supervision & Test Station of Zhejiang Tobacco Corporation, Hangzhou 310001, P.R. China
    In order to accurately determine N-nitroso nornicotine (NNN) and its metabolites in rabbit blood, a high-performance liquid chromatography/tandem mass spectrometry method was established by optimizing chromatographic conditions and mass spectrometric ...