1. CORESTA Congress, Kunming, 2018, Agronomy/Phytopathology Groups, AP 10

    Testing performance of tobacco varieties in water stress conditions

    CAMPANONI P.(1); LAPARRA H.(1); OZELLEY P.(1); DELLA CIANA P.(3); BISCARINI E.(3); MAURIZI L.(2); NARDONI N.(2); TRIPPELLA C.(2); GOEPFERT S.(1)
    (1) Philip Morris Products S.A. (part of Philip Morris International group of companies), PMI R&D, Neuchâtel, Switzerland; (2) Philip Morris Italia s.r.l., via Po 11-13-15, 00198, Roma, Italy; (3) L’Agricola s.r.l., Bastia Umbra, Perugia, Italy
    Increasing climate instability could lead to local agricultural constraints, presenting a risk for volumes and quality of tobacco supply. Selecting and breeding tobacco varieties for the ability to perform in unfavourable water conditions becomes a...
  2. CORESTA Congress, Kunming, 2018, Agronomy/Phytopathology Groups, AP 24

    Downregulation of a putative nitrate transporter gene substantially reduces the accumulation of TSNAs in air-cured tobaccos

    GOEPFERT S.(1); BOVET L.(1); LU J.(2); CAMPANONI P.(1); LEWIS R.S.(2); DEWEY R.E.(2)
    (1) Philip Morris Products S.A. (part of Philip Morris International group of companies), PMI R&D, Neuchâtel, Switzerland; (2) North Carolina State University, Department of Crop Science, Raleigh, NC, U.S.A.
    Air-cured Burley tobacco leaves typically exhibit high levels of nicotine-derived nitrosamine ketone (NNK) and N'-nitrosonornicotine (NNN). It has been previously demonstrated that leaf nitrate accumulation in air-cured tobaccos serves as the source...
  3. CORESTA Congress, Kunming, 2018, Agronomy/Phytopathology Groups, AP 49

    The influence of Nicotiana alata-derived introgression on plant malformations of tobacco breeding lines resistant to tomato spotted wilt virus

    KORBECKA-GLINKA G.(1); TROJAK-GOLUCH A.(1); DOROSZEWSKA T.(1); GOEPFERT S.(2)
    (1) Institute of Soil Science and Plant Cultivation - State Research Institute, Pulawy, Poland; (2) Philip Morris Products S.A. (part of Philip Morris International group of companies), PMI R&D, Neuchâtel, Switzerland
    Tomato spotted wilt virus (TSWV) is one of the most destructive viruses for tobacco cultivation. Cultivar “Polalta” carries a resistance gene introgressed from a wild species, Nicotiana alata, but the use of this cultivar in breeding is hampered by...
  4. CORESTA Congress, Kunming, 2018, Smoke Science/Product Technology Groups, ST 04

    Assessing the cytotoxicity of e-liquids without the use of the neutral red uptake assay

    McHUGH D.; CUDAZZO G.; VANSCHEEUWIJCK P.
    Philip Morris Products S.A. (part of Philip Morris International group of companies), PMI R&D, Neuchâtel, Switzerland
    As part of the pre-clinical assessment performed for consumer products in the tobacco industry, an in vitro assessment of a tobacco product’s cytotoxicity was performed using the neutral red uptake (NRU) assay. Since 2004, the CORESTA In Vitro Task...
  5. CORESTA Congress, Kunming, 2018, Smoke Science/Product Technology Groups, ST 52 (also presented at TSRC 2018)also presented at TSRC 2018)

    Consumers’ perceptions of disease-specific modified-risk claims are best evaluated in a disease-specific manner

    SHIFFMAN S.(1); CURTIN G.(2)
    (1) Pinney Associates, Pittsburgh, PA, U.S.A.; (2) RAI Services Company, Winston-Salem, NC, U.S.A.
    Manufacturers seeking to make claims about modified-risk tobacco products (MRTPs) must assess consumers' perceptions of risk reduction for these products. Claims made for the MRTP and assessment of perceived risk reduction can be global (e.g....
  6. CORESTA Congress, Kunming, 2018, Smoke Science/Product Technology Groups, ST 53 (also presented at TSRC 2018)

    Comparing direct and indirect assessments of perceptions of reduced risk for a modified-risk tobacco product

    SHIFFMAN S.(1); CURTIN G.(2)
    (1) Pinney Associates, Pittsburgh, PA, U.S.A.; (2) RAI Services Company, Winston-Salem, NC, U.S.A.
    Manufacturers seeking to make claims about modified-risk tobacco products (MRTPs) must assess consumers' perceptions of absolute and relative risks for these products. We cross-validate data from two methods: (a) indirect assessments based on the...
  7. CORESTA Congress, Kunming, 2018, Smoke Science/Product Technology Groups, STPOST 01

    Cross-sectional surveys on the use of tobacco products in the general population and in users of IQOS in Germany, Italy, and London (2018-2020): introducing the study protocols

    SPONSIELLO-WANG Z.; LANGER P.; PRIETO L.; DOBRYNINA M.; SKIADA D.; CAMILLE N.; WEITKUNAT R.; LÜDICKE F.
    Philip Morris Products S.A. (part of Philip Morris International group of companies), PMI R&D, Neuchâtel, Switzerland
    Background: Philip Morris International (PMI) launched cross-sectional surveys in Italy, Germany, and London in March 2018 following the commercialization of a heat-not-burn tobacco product, IQOS. This publication introduces the study protocols....
  8. CORESTA Congress, Kunming, 2018, Smoke Science/Product Technology Groups, STPOST 02

    Quantification of nitrogen oxides in aerosol of heat-not-burn IQOS product and combination of aerosol collection with the aerosol generation for TSNA analysis

    BADER P.; DEBRICK A.; GAUTIER L.; RADTKE F.; HUNKELER P.; MATERA R.; REYREN C.; CRENNA M.; STOOP A.
    Philip Morris Products S.A. (part of Philip Morris International group of companies), PMI R&D, Neuchâtel, Switzerland
    Nitrogen oxides (NOx), nitrogen monoxide (NO), and tobacco-specific nitrosamines (TSNA) are compounds that are analysed in the mainstream aerosol of heat-not-burn tobacco products, such as IQOS. The purpose of this study was to develop and validate a...
  9. CORESTA Congress, Kunming, 2018, Smoke Science/Product Technology Groups, STPOST 03

    Determination of nicotine, eugenol, menthol and aerosol formers in tobacco products and materials

    BELLO J.; D’AGOSTINO A.; JUVET-PECALVEL C.; NAGANATHAN K.; ROTA C.; GAUTIER L.; O’REILLY C.; DUPASQUIER N.; YERLY M.
    Philip Morris Products S.A. (part of Philip Morris International group of companies), PMI R&D, Neuchâtel, Switzerland
    The purpose of this study was to validate a unique method that simultaneously determines the concentration of nicotine, eugenol, menthol, and glycerin in Reduced-Risk Products tobacco products[1], and menthol and triacetin in materials. Analytes are...
  10. CORESTA Congress, Kunming, 2018, Smoke Science/Product Technology Groups, STPOST 30

    Effects of exposure to e-cigarette aerosols compared with cigarette smoke on 3D human buccal and small airway cultures: a systems toxicology assessment

    ISKANDER A.(1); STEINER S.(1); MAJEED S.(1); KONDYLIS A.(1); XIANG Yang(1); ZANETTI F.(1); FRENTZEL S.(1); MARTIN F.(1); PEITSCH M.C.(1); DOSHI U.(2); McKINNEY W.J.(2); LEE K.M.(2); HOENG J.(1)
    (1) Philip Morris Products S.A. (part of Philip Morris International group of companies), PMI R&D, Neuchâtel, Switzerland; (2) Altria Client Services LLC, Research, Development & Regulatory Affairs, Richmond VA, U.S.A.
    Considerable attention has been given toward the reduced risk potential of e-cigarettes (e-cigs). Most in vitro studies have focused on testing e-liquid formulations directly on submerged 2D cultures. Here, we examined the effects of exposure to the...