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27 results

  1. CORESTA Congress, Kunming, 2018, Smoke Science/Product Technology Groups, ST 01

    In vitro biological safety evaluation of cigarette smoke

    CHEN Xi(1,2); SHEN Y.(1,2); CHEN Hongyu(1,2); LIU F.(1,2); QI H.(3); JIMIN S.(3); TIMKO M.(4); FAN L.(1,2)
    (1) Research Center for Air Pollution and Health, Zhejiang University, Hangzhou, P.R. China; (2) Institute of Bioinformatics, Zhejiang University, Hangzhou, P.R. China; (3) Department of Pathology and Pathophysiology, School of Basic Medical Sciences, Zhejiang University, Hangzhou, P.R. China; (4) Department of Public Health Sciences, School of Medicine, University of Virginia, Charlottesville, VA, U.S.A.
    Traditionally, toxicological evaluation of cigarette smoke has focused on the harmful chemical content of smoke. Harm-reduced cigarettes should not only refer to these chemical compounds, but also to the degree of the effect of whole smoke on human cells. ...
  2. TSRC, Tob. Sci. Res. Conf., 2012, 66, abstr. 57

    Alterations in human bronchial epithelial cell transcriptomes following exposure to mainstream smoke from tobacco and non-tobacco cigarettes

    TIMKO M.P.; WOLKOWICZ M.J.; KOTOVA T.
    University of Virginia, Charlottesville, VA, USA
    Increased public awareness of the health risks associated with smoking has led to the development of numerous products aimed at promoting smoking cessation by purportedly reducing nicotine addiction and the harmful effects of tobacco smoke exposure. Using ...
  3. TSRC, Tob. Sci. Res. Conf., 2012, 66, abstr. 58

    RNA-seq analysis of alterations in human bronchial epithelial cell transcriptomes following exposure to electronic (e)-cigarette vapors

    TIMKO M.P.; WOLKOWICZ M.J.; KOTOVA T.; HOLBY S.N.
    University of Virginia, Charlottesville, VA, USA
    Increased public awareness and governmental concern of the health risks associated with smoking has led to the development of products aimed at reducing the harmful effects of tobacco smoke exposure and potentially promoting smoking cessation. Electronic ...
  4. TSRC, Tob. Sci. Res. Conf., 2010, 64, abstr. 02

    Functional genomics approaches to harm reduction in tobacco products

    TIMKO M.P.; RUSHTON P.J.; BOKOWIEC M.T.; ZHANG Hongbo
    University of Virginia, Dept. of Biology, Charlottesville, VA, USA; South Dakota State University, Dept. of Biology and Microbiology, Brookings, SD, USA
    There is overwhelming evidence that the use of tobacco products plays a major role in the pathogenesis of lung and oral cancers, cardiovascular disease, COPD, and a variety of other human diseases. In the absence of complete elimination of their use, a ...
  5. CORESTA Congress, Paris, 2006, PT 20

    Feature selection from near infrared spectra using genetic algorithms for tobacco blend recognition

    FIGUERES G.; DE SOUZA S.; REYNES C.; SABATIER R.; VIDAL B.
    Altadis Research Centre, Fleury-les-Aubrais, France
    Near infrared reflectance spectroscopy has proved to be very useful for predicting concentrations of chemical compounds in tobacco, classification or pattern recognition of cigarette blends. The resulting measurement of a sample is a whole reflectance ...
  6. CORESTA Congress, Paris, 2006, SS 01

    How representative of the human smoking behaviour would be the new alternative smoking regimes? A first attempt of assessment

    MARCHAND V.; TESSIER C.; DUMERY B.
    Altadis Research Centre, Fleury-les-Aubrais, France
    The ISO or FTC smoking conditions (35 mL- 2 s puffs, 1 puff per minute) have been more and more criticized during the last decade, especially because they would not reflect the human smoking behaviour. Their main objective was not to predict the exact ...
  7. CORESTA Congress, Paris, 2006, SS 13

    A mixture experimental design with six variables and the effects on smoke components:1 - Presentation of this experimental design and of some initial results on physical characteristics of cigarettes and blends

    VIDAL B.; FIGUERES G.; BIESSE J.P.; BREGEON B.; LOUVET F.; MUZELLEC L.
    Altadis Research Centre, Fleury-les-Aubrais, France
    The objective of this paper is to examine the effects of six tobacco components on the chemical and physical characteristics of blends and cigarettes and particularly on the mainstream smoke yields. First of all, we will develop the philosophy of this ...
  8. CORESTA Congress, Paris, 2006, SS 14

    A mixture experimental design with 6 variables and the effects on smoke components:2 - Hoffmann analytes behaviour through a mixture experimental design

    FIGUERES G.; VIDAL B.; BIESSE J.P.; BREGEON B.; LOUVET F.; MUZELLEC L.
    Altadis Research Centre, Fleury-les-Aubrais, France
    Today in the tobacco industry, one of the main scientific challenges is to understand the formation of some smoke compounds ("Hoffmann analytes"). For several years, work has been conducted in order to know the influence of cigarette design ...