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40 results

  1. CORESTA Meeting, Agronomy/Phytopathology, 2011, Santiago, AP 03

    Lowering TSNAs through nitrite reductase activity

    DAVENPORT S.E.; FORSYTH K.; TULLY L.; LISTER R.; LE LAY P.; MAUNDERS M.; SANCHEZ-TAMBURRINO J.P.
    Advanced Technologies Ltd., Cambridge, UK (holding of British American Tobacco Ltd.)
    Tobacco specific nitrosamines (TSNAs) are compounds in tobacco that have been shown to be carcinogenic. TSNAs are formed by the nitrosation of tobacco alkaloids with the main nitrosating agent believed to be nitrite. High levels of nitrate accumulation ...
  2. CORESTA Meeting, Agronomy/Phytopathology, 2011, Santiago, AP 27

    Tobacco Biotechnology: a tool for business solutions

    SANCHEZ-TAMBURRINO J.P.; EDWARDS K.; JONES L.; DAVENPORT S.E.
    Advanced Technologies Ltd., Cambridge, UK (holding of British American Tobacco Ltd.)
    Over the past 20 years, genetic modification and molecular breeding has been successfully used in many different crops to provide agronomic advantages (i.e., herbicide resistance, insect tolerance). However there are many other areas where it can be used ...
  3. CORESTA Congress, Shanghai, 2008, SSPTPOST 11

    Use of an EpiOralTM human tissue model for testing of substances for oral irritancy in vitro

    JAI T.S.; DELVES S.J.; FAUX S.P.; KUMARAVEL T.S.; NEILSON L.R.; MEREDITH C.
    Advanced Technologies Ltd., Cambridge, UK
    The EpiOralTM tissue model consists of normal human keratinocytes differentiated to form a multilayered tissue. The phenotype is analogous to human oral epithelium in vivo providing the opportunity for in vitro irritancy testing on human tissue. This ...
  4. CORESTA Meeting, Smoke Science/Product Technology, Jeju, 2007, SSPTPOST 12

    ISO 17025 accreditation for in vitro toxicology tests on cigarette smoke products

    COOKE L.; COWIN R.; LANGFORD R.; DELVES S.; GARCIA-CANTON C.; JONES S.; BLACK S.
    Advanced Technologies Ltd., Cambridge, UK
    One of the British American Tobacco Group of companies, Advanced Technologies (Cambridge) Ltd (ATC), performs 'duty of care' in vitro toxicology testing on tobacco products, to examine the potential harmful effects of cigarette smoke on DNA. ...