Search Results

49 results

  1. CORESTA Congress, Berlin, 2016, Smoke Science/Product Technology Groups, STPOST 33

    Accurate and reproducible dispensing of patterned picoliter quantities of tobacco extract onto apical surfaces of human 3D reconstructed airway tissues

    BEHRSING H.(1); SADOWSKI N.(1); CONSTANT S.(2); HUANG S.(2); RAABE H.(1)
    (1) Institute for In Vitro Sciences, Inc., Gaithersburg, MD, U.S.A.; (2) Epithelix Sàrl, Geneva, Switzerland
    There is an increasing need for researchers to understand the dynamic aspects of inhaled tobacco product exposure. Exposure-induced events can cause respiratory irritation, sensitisation, and other events that may lead to severe pulmonary disease. ...
  2. TSRC, Tob. Sci. Res. Conf., 2015, 69, abstr. 109

    3d reconstructed human airway models: effect of acclimation conditions on biomarker and inflammatory response following tissue challenge

    BEHRSING H.; RAABE H.A.; SHEEHAN D.W.; SLY E.A.; CURREN R.D.
    Institute for In Vitro Sciences, Gaithersburg, MD USA
    Human reconstructed, 3-dimensional (3D) airway tissues present researchers with organotypic models that consist of heterogenous cell types that more accurately reflect the pulmonary airway in vivo. These in vitro models are now increasingly applied to ...
  3. CORESTA Congress, Quebec, 2014, Smoke Science/Product Technology Groups, ST 15

    Evaluation of the EpiOral™ reconstructed human oral buccal tissue model as a testing platform for determining the oral irritation potential of tobacco products

    RAABE H.; BARNES N.; HILBERER A.
    Institute for In Vitro Sciences, Inc., Gaithersburg, MD, U.S.A.
    There is an increasing need by the tobacco industry to evaluate the oral/buccal irritation potential of tobacco products both to support product development goals and for sound product stewardship. The use of in vitro human cell and tissue-based test ...
  4. TSRC, Tob. Sci. Res. Conf., 2014, 68, abstr. 05

    The use of precision-cut lung slices to assess inflammation, parenchymal damage, and collagen deposition: three markers of tobacco exposure-induced pulmonary toxicity

    BEHRSING H.P.
    Institute for In Vitro Sciences, Inc., Gaithersburg, Maryland, USA
    The Family Smoking Prevention and Tobacco Control Act (TCA) gives the Food and Drug Administration (FDA) broad authority to regulate tobacco products. The FDA-Center for Tobacco Products (CTP) calls for several research priority areas, including in vitro ...
  5. CORESTA Meeting, Agronomy/Phytopathology, 2011, Santiago, AP 03

    Lowering TSNAs through nitrite reductase activity

    DAVENPORT S.E.; FORSYTH K.; TULLY L.; LISTER R.; LE LAY P.; MAUNDERS M.; SANCHEZ-TAMBURRINO J.P.
    Advanced Technologies Ltd., Cambridge, UK (holding of British American Tobacco Ltd.)
    Tobacco specific nitrosamines (TSNAs) are compounds in tobacco that have been shown to be carcinogenic. TSNAs are formed by the nitrosation of tobacco alkaloids with the main nitrosating agent believed to be nitrite. High levels of nitrate accumulation ...
  6. CORESTA Meeting, Agronomy/Phytopathology, 2011, Santiago, AP 27

    Tobacco Biotechnology: a tool for business solutions

    SANCHEZ-TAMBURRINO J.P.; EDWARDS K.; JONES L.; DAVENPORT S.E.
    Advanced Technologies Ltd., Cambridge, UK (holding of British American Tobacco Ltd.)
    Over the past 20 years, genetic modification and molecular breeding has been successfully used in many different crops to provide agronomic advantages (i.e., herbicide resistance, insect tolerance). However there are many other areas where it can be used ...