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7 results

  1. CORESTA Congress, Berlin, 2016, Smoke Science/Product Technology Groups, STPOST 26

    A review of aerosol exposure systems relative to the analysis of cytotoxicity: a CORESTA In vitro Toxicity Testing Sub-Group perspective

    THORNE D.(1); WIECZOREK R.(2); FUKUSHIMA T.(3); SHIN H.J.(4); LEVERETTE R.(5); BALLANTYNE M.(6); LI X.(7); BOMBICK B.(5)
    (1) British American Tobacco, R&D Centre, Southampton, U.K.; (2) Reemtsma Cigarettenfabriken GmbH (an Imperial Brands PLC Company), Hamburg, Germany; (3) Japan Tobacco Inc., Scientific Product Assessment Centre, Yokohama, Kanagawa, Japan; (4) KT&G Corporation, Daejeon, South Korea; (5) RAI Services Company, Winston-Salem, NC, U.S.A.; (6) Covance Laboratories Ltd, Harrogate, U.K.; (7) Zhengzhou Tobacco Research Institute of CNTC, Zhengzhou, P.R. China
    Aerosol exposure systems offer researchers a variety of ways to customise the exposure set-up, modify experimental parameters and provide a novel and versatile platform for in vitro aerosol research. These systems produce an aerosol that more closely ...
  2. TSRC, Tob. Sci. Res. Conf., 2015, 69, abstr. 75

    Impacts of total particulate matter from cigarette smoke on early development of Zebrafish (Danio rerio)

    PRASAD G.L.(1); MASSARSKY A.(2); JAYASUNDARA N.(2).; DIGIULIO R.T.(2); BAILEY J.(3); LEVIN E.(3)
    (1) R.J. Reynolds Tobacco Company, Winston-Salem, North Carolina, USA; (2) Duke University, Durham, NC USA; (3) Duke University Medical Center, Durham, NC USA
    Cigarette smoke has been associated with a number of pathologies; however mechanisms leading to developmental effects are yet to be fully understood. This study examined the effects of Total Particulate Matter (TPM) from 3R4F reference cigarettes on the ...
  3. TSRC, Tob. Sci. Res. Conf., 2013, 67, abstr. 28

    The tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) induces mitochondrial and nuclear DNA damage in Caenorhabditis elegans.

    PRASAD G.L.(1); BODHICHARLA R.(2); MEYER J.N.(2).
    (1) R.J. Reynolds Tobacco Company, Winston-Salem, NC, USA; (2) Duke University, Durham, NC, USA
    The metabolites of the tobacco-specific nitrosamine NNK form DNA adducts in animal models. A previous report indicates that NNK could cause damage to the mitochondrial as well as nuclear genome in rats (Stepanov and Hecht, 2009 Chem. Res. Toxicol. 22: 406 ...
  4. CORESTA Congress, Sapporo, 2012, Smoke Science/Product Technology Groups, SS 05

    Evaluation of a panel of potential gene biomarkers in two in vitro lung models following exposure to tobacco smoke and extracts

    FIELDS W.R.(1,2); LIEDTKE W.(2); LI J.(2); BOMBICK B.R.(1)
    (1) R.J. Reynolds Tobacco Co., R&D Department, Winston-Salem, NC, USA; (2) Integrated Toxicology and Environmental Health Program, Duke University, Durham, NC 27710, USA
    Lung cells are frequently used in in vitro studies to assess the impact of cigarette smoke on defense and repair mechanisms of the lung. Previously, we identified a panel of fifteen genes representing inflammation, oxidative stress, metabolism and ...
  5. Tob. Sci., 1992, 36, p. 8-9., ISSN.0082-4623.

    Species composition of parasitoids of the tobacco aphid, Myzus nicotianae Blackman (Homoptera: Aphididae) in Eastern Tennessee

    SONG J.; PLESS C.D.; MILLER R.D.
    University of Florida, Dept. of Entomology and Nematology, Gainesville, FL, USA.
    The tobacco aphid, Myzus nicotianae Blackman, was commonly parasitized on tobacco plants, Nicotiana tabacum L., in greenhouses but rarely in the field. Five species of primary hymenopteran parasitoids were collected from greenhouses; only one primary ...