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  1. CORESTA Meeting, Smoke Science/Product Technology, 2017, Kitzbühel, STPOST 51

    RNA-seq-based toxicogenomics shows limited impact of e-cigarette vapour on airway cells compared with cigarette smoke when matching for nicotine delivery

    HASWELL L.; BAXTER A.; BANERJEE A.; MUSHONGANONO J.; ADAMSON J.; THORNE D.; GAҪA M.; MINET E.
    British American Tobacco (Investments) Limited, R&D, Southampton, U.K.
    There is increasing evidence from in vitro testing that e-cigarettes cause minimal damage to cell systems: however some studies reported cytotoxicity and inflammatory responses. In this study we compared the transcriptional response of MucilAir™...
  2. TSRC, Tob. Sci. Res. Conf., 2011, 65, abstr. 12

    An examination of the biological effects of reduced toxicant prototype cigarettes using in vitro models of smoking-related diseases.

    FEARON I.M.; TAYLOR M.; CARR T.; COCKCROFT N.; SMITH G-F.; HEWITT K.; HASWELL L.; BISHOP E.; PHILLIPS G.
    British American Tobacco, GR&D, Southampton, UK
    INTRODUCTION: A potential approach to reduce the harm associated with cigarette smoking is to reduce smoke toxicant levels. In vitro models of smoking-related diseases may provide screening tools for cigarettes with altered smoke toxicant levels and...
  3. CORESTA Congress, Paris, 2006, SSPOST 24

    Development of an in vitro alternative model for the measurement of cigarette smoke induced DNA damage using 3-D human lung cell cultures

    THORNE D.; HASWELL L.; FIEBELKORN S.; BREHENY D.; RICHTER A.
    British American Tobacco, Group R&D, Southampton, UK
    Cigarette smoking has been associated with the development of lung cancer and chronic obstructive pulmonary disease, which may be linked to the oxidative damage of biomolecules and DNA, through direct or indirect mechanisms. The modified in vitro...