1. TSRC, Tob. Sci. Res. Conf., 2011, 65, abstr. 20

    An in vitro comparative study of [14c]-eugenol and [14c]-methyleugenol activation and detoxification kinetics in human, mouse, and rat liver fractions.

    MINET E.(1); GENTILE D.(2); MEREDITH C.(1); MASSEY E.D.(1)
    (1) British American Tobacco, Group R&D, Southampton, UK; (2) Charles River Laboratories, Edinburgh, UK
    Introduction - Eugenol is a natural alkenylbenzene compound used in a variety of consumer products including Kretek cigarettes. There is limited evidence for the carcinogenicity of eugenol to experimental animals. However, in vitro tests for the...
  2. CORESTA Congress, Shanghai, 2008, SSPTPOST 11

    Use of an EpiOralTM human tissue model for testing of substances for oral irritancy in vitro

    JAI T.S.; DELVES S.J.; FAUX S.P.; KUMARAVEL T.S.; NEILSON L.R.; MEREDITH C.
    Advanced Technologies Ltd., Cambridge, UK
    The EpiOralTM tissue model consists of normal human keratinocytes differentiated to form a multilayered tissue. The phenotype is analogous to human oral epithelium in vivo providing the opportunity for in vitro irritancy testing on human tissue....