Search Results

3 results

  1. CORESTA Meeting, Smoke Science/Product Technology, 2019, Hamburg, STPOST 29

    Reversibility of in vitro biological effects in cigarette smoke-exposed 3D lung tissues following switching to a tobacco heating product

    HASWELL L.E.; BREHENY D.; CORKE S.; JAUNKY T.; SANTOPIETRO S.; BAXTER S.; MINET E.; THORNE D.; GACA M.
    British American Tobacco, Southampton, U.K.
    Tobacco heated products (THPs) potentially offer a safer alternative to combustible cigarettes. Recent in vitro studies have shown reduced THP biological effects compared to 3R4F reference cigarette smoke. Existing in vitro data, however, has been...
  2. CORESTA Meeting, Smoke Science/Product Technology, 2019, Hamburg, STPOST 30

    In vitro RNA-seq-based toxicogenomics assessment shows reduced biological effect of tobacco heating products when compared to cigarette smoke

    MEREDITH S.; HASWELL L.E.; CORKE S.; VERRASTRO I.; BAXTER A.; BANERJEE A.; ADAMSON J.; JUANKY T.; PROCTOR C.J.; MINET E.; GACA M.
    British American Tobacco, Southampton, U.K.
    The battery of regulatory tests used to evaluate the risk of novel tobacco products such as heated tobacco products (THPs) presents some limitations including a bias towards the apical endpoints tested, and limited information on the mode of action....
  3. CORESTA Congress, Edinburgh, 2010, SSPTPOST 19

    Bronchial epithelial cell (NCI-H292) response to cigarette smoke total particulate matter (TPM): Development and utilisation of a simple cell culture model of chronic obstructive pulmonary disease (COPD)

    FOSS-SMITH G.; HEWITT K.; HASWELL L.E.; CORKE S.; GARCIA-CANTON C.; PHILLIPS G.J.
    British American Tobacco, Group R&D, Southampton, UK
    COPD is a complex and multifaceted condition that can be caused by cigarette smoking. In smokers, chronic exposure can lead to the development of COPD specific pathologies such as emphysema, small airway disease and mucus hyper-secretion. On a...