Search Results

16 results

  1. CORESTA Congress, Berlin, 2016, Agronomy/Phytopathology Groups, AP 17

    Using RNP CRISPR to create ultra-low nicotine tobacco

    SHEN Y.(1); QI D.(2); YANG J.(1); KUDITHIPUDI C.(1); XU D.(1); WAREK U.(1); STRICKLAND J.(1)
    (1) Altria Client Services LLC, Research, Development and Regulatory Affairs, Richmond, VA, U.S.A.; (2) Eurofins Lancaster Laboratories, Lancaster, PA, c/o Altria Client Services LLC, Richmond, VA, U.S.A.
    Nicotine is the most abundant alkaloid in cultivated tobacco (Nicotiana tabacum), typically constituting more than 90% of total alkaloids. Our research showed that nicotine levels in PMT-RNAi and PR50-RNAi lines were reduced more than 95% and 80-90%,...
  2. CORESTA Congress, Berlin, 2016, Agronomy/Phytopathology Groups, AP 20

    Ultra-low nicotine tobacco lines with improved leaf quality

    KUDITHIPUDI C.(1); MORRIS J.W.(1); LUSSO M.(1); SHEN Y.(1); QI D.(2); DAVIS G.A.(1); LION K.(1); XU D.(1); WAREK U.(1); STRICKLAND J.(1)
    (1) Altria Client Services LLC, Research, Development and Regulatory Affairs, Richmond, VA, U.S.A.; (2) Eurofins Lancaster Laboratories, Lancaster, PA, c/o Altria Client Services LLC, Richmond, VA, U.S.A.
    Nicotine is the most abundant alkaloid in cultivated tobacco (Nicotiana tabacum), typically constituting more than 90% of total alkaloids. The remaining fraction consists of three minor alkaloids: nornicotine, anabasine and anatabine. Genetic control...
  3. CORESTA Congress, Berlin, 2016, Agronomy/Phytopathology Groups, AP 54

    The regulation of autophagy of susceptible Nicotiana tabacum under tobacco mosaic virus infection

    YANG Jinguang(1); LIU Xaingfu(1); LIU Wei(1); QIAN Yumei(1); ZHANG Jing(2); LI Wei(2); DONG Shifei(2); WANG Yaofeng(3); HUANG Mingdi(4); WANG Fenglong(1)
    (1) Tobacco Research Institute, Chinese Academy of Agricultural Sciences, Key Laboratory of Tobacco Pest Monitoring Controlling & Integrated Management, Qingdao, P.R. China; (2) Hongyun Honghe Tobacco (Group) Co., Ltd., Kunming, P.R. China; (3) Qingyang Branch of Gansu Province Tobacco Company, Xifeng, P.R. China; (4) Longnan Tobacco Company, Gansu Tobacco Cooperation, Wudu 746000, P.R. China
    Autophagy (or self-eating) is an important conserved process by which eukaryotic cells recycle intracellular components. This study was undertaken to elucidate whether tobacco mosaic virus (TMV) infection on tobacco plants induced autophagy. TMV-U1...
  4. CORESTA Congress, Berlin, 2016, Poster Session, APSTPOST 02 (also presented at TSRC 2016)

    The CORESTA Website

    MANSION B.(1); LAURES F.(1); DE TERVARENT N.(2); GUITTON P.M.(2); MARIGNAC E.(2); COLARD S.(3); JACK A.M.(4); STEVENS R.(5); WAGNER K.A.(6)
    (1) Mamasam, Vincennes, France; (2) CORESTA, Paris, France; (3) SEITA-Imperial Tobacco, Fleury-les-Aubrais, France; (4) University of Kentucky, KTRDC, Lexington, KY, U.S.A.; (5) ITG Brands, Greensboro, NC, U.S.A.; (6) Altria Client Services LLC, Richmond, VA, U.S.A.
    Over the past few years, CORESTA work procedures and communication policies have been evolving in line with the association's vision is to be "an authoritative source of publically available credible science and best practices related to tobacco and...
  5. CORESTA Congress, Berlin, 2016, Smoke Science/Product Technology Groups, ST 21 (also presented at TSRC 2016)

    Characterization of puff topography during 8-hours of ad libitum use of MarkTen® e-vapor products

    EDMISTON J.; LIANG Q.; VANSICKEL A.; LIU J.; ZHAO Y.; SARKAR M.
    (1) Altria Client Services LLC, Research, Development and Regulatory Affairs, Richmond, VA, U.S.A.; (2) Eurofins Lancaster Laboratories, Lancaster, PA, c/o Altria Client Services LLC, Richmond, VA, U.S.A.
    Introduction: The purpose of this study was to characterize the puff topography variables following use of MarkTen® electronic cigarettes by adult conventional cigarette smokers [CS], adult cigarette and e-vapor dual users [DU] and adult exclusive...
  6. CORESTA Congress, Berlin, 2016, Smoke Science/Product Technology Groups, ST 34

    Computational modeling of e-vapor aerosol dynamics and deposition in the respiratory tract

    ROSTAMI A.A.(1); CASTRO N.(1); PITHAWALLA Y.B.(1); OLDHAM M.J.(1); ZHANG J.(2); LI W.(1); FENG Y.(3)
    (1) Altria Client Services LLC, Research, Development and Regulatory Affairs, Richmond, VA, U.S.A.; (2) Eurofins Lancaster Laboratories, Lancaster, PA, c/o Altria Client Services LLC, Richmond, VA, U.S.A.; (3) School of Chemical Engineering, Oklahoma State University, Stillwater, OK, U.S.A.
    It is important for risk assessment of e-vapor products to understand: (1) how much of each aerosol constituent is deposited in the buccal cavity, upper and lower respiratory tracts? and (2) in what form (vapor or liquid) each aerosol constituent is...
  7. TSRC, Tob. Sci. Res. Conf., 2016, 70, abstr. 17

    Ex vivo effects of smokeless tobacco extracts on select immune responses

    PRASAD G.L.(1); ARIMILLI S.(2); DAMRATOSKI B.E.(2); SCHMIDT E.(1); ROWE J.(3); CHOUCHANE S.(4)
    (1) RAI Services Company; (2) Wake Forest University Health Sciences; (3) R.J. Reynolds Tobacco Co.; (4) Eurofins Lancaster Labs Inc, Winston-Salem, NC, USA
    Our previous work demonstrated that exposure to Tobacco Product Preparations (TPPs) from combustible tobacco cause cytotoxic and select immunosuppressive effects in PBMCs, and this ex vivo model is well suited to investigate the chronic immune...