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15 results

  1. CORESTA Congress, Kunming, 2018, Agronomy/Phytopathology Groups, APPOST 11

    Field trials with low nicotine tobacco varieties developed by conventional breeding technique: first results

    MALPICA A.(1); EVANS W.(2); ARCHIBALD C.(3); SCOTT L.(4); GARWE D.(5); CHAMANGO A.M.Z.(6); DORLHAC de BORNE F.(7); COLARD S.(8)
    (1) Bergerac Seed and Breeding, Bergerac, France; (2) Imperial Tobacco South Africa Pvt. Ltd, Umhlanga, Durban, South Africa; (3) Alliance One International Services, Camberley, Surrey, U.K.; (4) Universal Leaf Tobacco Co., Richmond, VA, U.S.A.; (5) Tobacco Research Board (TRB), Harare, Zimbabwe; (6) Agricultural Research & Extension Trust (ARET), Lilongwe, Malawi; (7) Imperial Tobacco Limited, Bergerac, France; (8) SEITA - Imperial Brands plc, Paris, France
    In 2015, the World Health Organisation (WHO) Study Group on Tobacco Product Regulation (“TobReg”) issued an advisory note recommending a strategy of reducing nicotine in tobacco to substantially lower levels of 0.4 mg/g. In the U.S., the Food and Drug ...
  2. CORESTA Congress, Kunming, 2018, Smoke Science/Product Technology Groups, STPOST 52

    Biological test procedure for fresh generated cigarette smoke and e-cigarette aerosols under air-liquid interface (ALI) exposure in 24 and 96 multi-well plates

    WIECZOREK R.(1); TRELLES STICKEN E.(1); WALELE T.(2); CZEKALA L.(3); SIMMS L.(3)
    (1) Reemtsma Cigarettenfabriken GmbH, Imperial Brands plc, Hamburg, Germany; (2) Fontem Ventures, Amsterdam, The Netherlands; (3) Imperial Tobacco Limited, Bristol, U.K.
    Cigarette smoke and e cigarette aerosol contain particulate matter/liquid droplets in the solid phase as well as volatile substances in the gas phase. Both fractions are of potential toxicological relevance and should be considered when assessing ...
  3. CORESTA Congress, Kunming, 2018, Smoke Science/Product Technology Groups, STPOST 53

    Use of human derived cell lines to increase the biological relevance of cigarette condensate, non-tobacco materials and e-liquids testing

    WIECZOREK R.(1); TRELLES STICKEN E.(1); WALELE T.(2); CZEKALA L.(3); SIMMS L.(3)
    (1) Reemtsma Cigarettenfabriken GmbH, Imperial Brands plc, Hamburg, Germany; (2) Fontem Ventures, Amsterdam, The Netherlands; (3) Imperial Tobacco Limited, Bristol, U.K.
    The in vitro testing strategy of tobacco products is mainly based on the testing of extracts from cigarette smoke condensates. An accepted industry wide assay battery has been developed over recent years which delivers reliable results for the ...
  4. CORESTA Meeting, Smoke Science/Product Technology, 2017, Kitzbühel, STPOST 08

    Indoor air quality and surface deposition assessment following use of an open system e-cigarette

    BAUER N.(1); TSCHIERSKE N.(1); O'CONNELL G.(2); CAHOURS X.(3)
    (1) Reemtsma Cigarettenfabriken GmbH (an Imperial Brands PLC Company), Hamburg, Germany; (2) Fontem Ventures B.V. (an Imperial Brands PLC Company), Amsterdam, The Netherlands; (3) SEITA-Imperial Tobacco Limited, Fleury-les-Aubrais, France
    Electronic cigarette (e-cigarette) nicotine delivery devices are growing in popularity worldwide. Both regulators and public health organisations are beginning to examine potential implications that exposure to exhaled e-cigarette aerosol may have on non ...
  5. CORESTA Meeting, Smoke Science/Product Technology, 2017, Kitzbühel, STPOST 21

    The use of in vitro human biomarkers from relevant primary cell lines, to assess the effects of increasing nicotine concentration in e-liquids

    SIMMS L.(1); STEVENSON M.(1); CZEKALA L.(1); TSCHIERSKE N.(1); BERG E.(2); WALELE T.(3)
    (1) Imperial Tobacco Ltd, Bristol, U.K.; (2) DiscoverX Corporation, Fremont, CA, U.S.A.; (3) Fontem Ventures B.V. (an Imperial Brands PLC Company), Amsterdam, The Netherlands
    As part of the ongoing stewardship of electronic cigarettes, and in line with the National Academies of Sciences “ Toxicity Testing in the 21st Century: A Vision and a Strategy ”, Fontem Ventures B.V. have investigated the utility of a series of endpoints ...
  6. CORESTA Meeting, Smoke Science/Product Technology, 2017, Kitzbühel, STPOST 53

    Non-targeted screening of extractables and leachables in e-cigarettes using a Single Platform UPLC-APGC-QTOF-MS

    MERUVA N.(1); CABOVSKA B.(1); SHAH D.(1); ORGANTINI K.(1); McCALL E.(2); CLELAND G.(1); ROZENICH R.(3); SCHREINER H.(3)
    (1) Waters Corporation, Milford, MA, U.S.A.; (2) Waters Corporation, Wilmslow, U.K.; (3) Waters GmbH, Vienna, Austria
    Characterization of extractables and leachables is essential for ensuring the safety, quality and efficacy of inhalation tobacco products such as e-cigarettes. The initial step for characterizing extractables from e-cigarettes involves targeted screening, ...
  7. CORESTA Meeting, Smoke Science/Product Technology, 2017, Kitzbühel, STPOST 54

    Ion mobility mass spectrometry: a new tool for characterization of complex tobacco products

    MULLIN L.(1); MERUVA N.(1); McCALL E.(2); CLELAND G.(1); ROZENICH R.(3); SCHREINER H.(3)
    (1) Waters Corporation, Milford, MA, U.S.A.; (2) Waters Corporation, Wilmslow, U.K.; (3) Waters GmbH, Vienna, Austria
    Comprehensive chemical profiling and identification of compounds in tobacco and tobacco smoke matrices is a challenging task due to the sample complexity and the wide array of analyses required. LC-MS and GC-MS based methods are typically applied as they ...
  8. CORESTA Meeting, Smoke Science/Product Technology, 2017, Kitzbühel, STPOST 55

    Rapid authentication of tobacco flavors using DART-MS

    ORGANTINI K.(1); MERUVA N.(1); McCALL E.(2); CLELAND G.(1); ROZENICH R.(3); SCHREINER H.(3)
    (1) Waters Corporation, Milford, MA, U.S.A.; (2) Waters Corporation, Wilmslow, U.K.; (3) Waters GmbH, Vienna, Austria
    Characterization of flavors in tobacco products is critical for consumer’s perception of aroma, taste, quality and branding. Maintaining consistent flavor in tobacco products requires quality control testing of raw materials and finished products to ...
  9. CORESTA Meeting, Smoke Science/Product Technology, 2017, Kitzbühel, STPOST 56

    Benefits of mass detection for routine LC analysis of tobacco products

    MERUVA N.(1); YANG J.(1); McCALL E.(2); ROZENICH R.(3); SCHREINER H.(3)
    (1) Waters Corporation, Milford, MA, U.S.A.; (2) Waters Corporation, Wilmslow, U.K.; (3) Waters GmbH, Vienna, Austria
    There are several tobacco industry methods that rely on HPLC separation and optical detection (UV, Fluorescence and ELSD) for identification of target compounds such as carbonyls, nicotine, related alkaloids, sugars and artificial sweeteners. In this ...