1. CORESTA Meeting, Smoke Science/Product Technology, 2019, Hamburg, ST 45

    Meta-analysis of two biomarkers of exposure of tobacco products

    AYALA-FIERRO F.(1); ELAMIN A.(2); FROST-PINEDA K.(3); JIN T.(3); PRASAD G.L.(3); SARKAR M.(4); SCHMIDT E.(3); VERRON T.(5)
    (1) ITG Brands LLC, Greensboro, NC, U.S.A.; (2) PMI R&D, Philip Morris Products S.A., Neuchâtel, Switzerland; (3) RAI Services Company, Winston-Salem, NC, U.S.A.; (4) Altria Client Services LLC, Richmond, VA, U.S.A.; (5) SEITA - Imperial Brands, Paris, France
    In the context of tobacco products, broadly two types of biomarkers exist, biomarkers of exposure (BoE) and biomarkers of potential harm (BoPH). BoE measure exposure to tobacco constituents, e.g. carbon monoxide (CO) and nicotine equivalents (NEQs). The ...
  2. CORESTA Meeting, Smoke Science/Product Technology, 2019, Hamburg, STPOST 05

    Computational simulation of aerosol generation and temperature regulation performance of nicotine salt pod system

    BLACK W.; ALSTON W.; HOLLOWAY G; ZHANG J.T.
    JUUL Labs, San Francisco, CA, U.S.A.
    The JUUL Nicotine Salt Pod System (NSPS) is a pre-filled (closed), non-modifiable, vapor-based electronic nicotine delivery system (ENDS) featuring automated temperature regulation. The system is designed to minimize the generation of degradation products ...
  3. CORESTA Meeting, Smoke Science/Product Technology, 2019, Hamburg, STPOST 06

    Correlation between heating temperature of the JUUL e-cigarette and carbonyl formation

    MOGADDEDI H.; MYERS D.; JAMESON B.; HATTON C.; BHAT N.
    JUUL Labs, San Francisco, CA, U.S.A.
    Electronic cigarettes (EC) have the potential to pose reduced risk to the consumer compared to combustion products, due to the absence of toxic byproducts of combustion. These products function by heating and vaporizing e-liquid at lower temperatures. One ...
  4. CORESTA Meeting, Smoke Science/Product Technology, 2019, Hamburg, STPOST 07 (also presented at TSRC 2019)

    HPHC analysis of seven flavors of a temperature-regulated nicotine salt-based pod system

    COOK D.(1); HIRAKI B.(1); MISRA M.(1); GILLMAN I.G.(2)
    (1) JUUL Labs, San Francisco, CA, U.S.A.; (2) Enthalpy Analytical, LLC, Richmond, VA, U.S.A.
    The JUUL Nicotine Salt Pod System (NSPS) has no user modifiable settings and is temperature regulated to minimize the generation of combustion related byproducts. Aerosol generated from NSPS pods using a cotton wicking material was evaluated for harmful ...
  5. CORESTA Meeting, Smoke Science/Product Technology, 2019, Hamburg, STPOST 33

    Quantitative risk assessment (QRA) indicates reduced risk potential for carcinogenic and non-carcinogenic effects of the aerosol of the next generation products (NGPs) compared to reference cigarettes

    AYALA-FIERRO F.(1); CZEKALA L.(2); SIMMS L.(2); RUDD K.(2); CAVA G.(2); STEVENSON M.(2)
    (1) ITG Brands LLC, Greensboro, NC, U.S.A.; (2) Imperial Brands PLC, Bristol, U.K.
    In order to understand the potential relative health risks of NGPs compared to cigarettes, we compared the relative risks of aerosols from tobacco-containing and tobacco-free NGPs to the smoke generated from a reference cigarette. Quantitative Risk ...
  6. CORESTA Meeting, Smoke Science/Product Technology, 2019, Hamburg, STPOST 35 (also presented at TSRC 2019)

    Neutral red uptake (NRU) cytotoxicity analysis of aerosol generated from a temperature-regulated nicotine salt based product utilizing cotton wicking material

    COOK D.(1); HIRAKI B.(1); MISRA M.(1); GILLMAN I.G.(2)
    (1) JUUL Labs, San Francisco, CA, U.S.A.; (2) Enthalpy Analytical, LLC, Richmond, VA, U.S.A.
    The JUUL Nicotine Salt Pod System (NSPS) has no user modifiable settings and is temperature regulated to minimize the generation of combustion-related byproducts. Aerosol generated from NSPS pods using a cotton wicking material was evaluated for ...
  7. CORESTA Meeting, Smoke Science/Product Technology, 2019, Hamburg, STPOST 58

    A consortium approach for consumer-reported outcome measures to assess tobacco- and nicotine-containing products

    ACQUADRO C.(1) on behalf of the CORESTA CROM Task Force: AYALA-FIERRO F.(2); BLACK R.(3); CAHOURS X.(4); CHREA C.(5); CURTIN G.(6); GILES L.(7); McCAFFREY S.(3); PARK C.H.(8); PRASAD K.(9); SHERWOOD N.(10); SHIFFMAN S.(11); SMITH J.(6); SPIES E.(5)
    (1) Mapi Research Trust, Lyon, France; (2) ITG Brands, Greensboro, NC, U.S.A.; (3) Altria Client Services, Richmond, VA, U.S.A.; (4) SEITA - Imperial Brands, Paris, France; (5) Philip Morris Products S.A., Neûchatel, Switzerland; (6) RAIS, Winston-Salem, NC, U.S.A.; (7) JT Int'l SA, Genève, Switzerland; (8) KT&G Research Institute, Daejeon, Republic of Korea; (9) British American Tobacco, Southampton, U.K.; (10) Neil Sherwood Consulting, Commugny, Switzerland; (11) Pinney Associates, Pittsburgh, PA, U.S.A.
    In the tobacco space, consumer-reported outcome measures (CROM) are essential for understanding motivations, subjective effects, and behavior. Such measures have become particularly important with the advent of candidate modified risk tobacco products ...