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398 results

  1. CORESTA Congress, Kunming, 2018, Smoke Science/Product Technology Groups (Workshop), STW 08

    Biomarker qualification using adverse outcome pathways (AOPs)

    McEWAN M.; LOWE F.; GACA M.; HARDIE G.; MURPHY J.; PROCTOR C.J.
    British American Tobacco (Investments) Limited, R&D, Southampton, U.K.
    Smoking is a leading cause of numerous human disorders including pulmonary disease, cardiovascular disease and cancer. Disease development is primarily caused by years of exposure to cigarette smoke constituents, many of which are known toxicants. ...
  2. CORESTA Congress, Kunming, 2018, Smoke Science/Product Technology Groups, ST 17

    A clinical study investigating changes in exposure to cigarette smoke chemicals in U.K. smokers who switch to using a tobacco heating product for a five-day period

    McEWAN M.(1); EBAJEMITO J.K.(1); GALE N.(1); ELDRIDGE A.(1); CAMACHO O.M.(1); MURPHY J.(1); HARDIE G.(1); PROCTOR C.J.(1)
    (1) British American Tobacco (Investments) Limited, R&D, Southampton, U.K.; (2) Celerion Inc., Lincoln, NE, U.S.A.
    Smoking is a leading cause of numerous diseases, particularly lung cancer, chronic obstructive pulmonary disease and cardiovascular diseases. Consequently, there is a recognized need to provide smokers with alternative nicotine-delivery devices that have ...
  3. CORESTA Congress, Kunming, 2018, Smoke Science/Product Technology Groups, ST 28

    Measurement of puffing topography and mouth level exposure: Japan

    PRASAD K.; GEE J.; SLAYFORD S.; GRAY A.; NOTHER K.; CUNNINGHAM A.; MAVROPOULOU E.; PROCTOR C.J.
    British American Tobacco (Investments) Limited, Group R&D, Southampton, U.K.
    Background: BAT has developed the Tobacco Heating Product THP (1.0) which comprises an electrical heating device (glo™ device) and consumable tobacco rods (Neostiks™). A use behaviour study was conducted to demonstrate that consumers use this product in a ...
  4. CORESTA Congress, Kunming, 2018, Smoke Science/Product Technology Groups, ST 45

    Time and spatially resolved in-situ temperature and pressure measurements with soft ionisation mass spectrometry inside a burning superslim cigarette. Part II – thermochemical mapping

    EHLERT S.(1,3); CUI Huapeng.(2); HEIDE J.(3); XIE Fuwei(2); DENG Nan(2); LIU Chuan(4); McADAM K.(4); WALTE A.(1); ZIMMERMANN R.(3)
    (1) Photonion GmbH, Schwerin, Germany; (2) Zhengzhou Tobacco Research Institute of CNTC, Zhengzhou, Henan, P.R. China; (3) University of Rostock, Dept. of Analytical Chemistry, Rostock, Germany; (4) British American Tobacco, R&D Centre, Southampton, U.K.
    Superslim cigarettes are an increasingly popular category of cigarettes in China. Accurate measurements of key thermophysical and thermochemical parameters in superslim cigarettes is essential for mechanistic understanding of pyrolysis processes, thermal ...
  5. CORESTA Congress, Kunming, 2018, Smoke Science/Product Technology Groups, ST 54

    A cross-sectional survey to assess tobacco and nicotine product use behaviour in Japan

    ADAMSON J.; PRASAD K.; CAMACHO O.M.; MURPHY J.
    British American Tobacco (Investments) Limited, R&D, Southampton, U.K.
    The rapid emergence of next generation products (NGPs), with their potential to reduce exposure to harmful substances, has substantially changed the tobacco and nicotine landscape in recent years. The impact of introducing NGPs on individuals and the ...
  6. CORESTA Congress, Kunming, 2018, Smoke Science/Product Technology Groups, ST 64

    What fundamental tobacco science teaches us about heated tobacco products – assessment on THP1.0

    EATON D.; JAKAJ B.; FORSTER M.; LIU Chuan; PRASAD K.
    British American Tobacco (Investments) Limited, R&D, Southampton, U.K.
    Heated tobacco products are designed to reduce toxicant emissions in aerosol as compared to cigarette smoke. Different heating mechanisms have been used in this type of product, either using solid fuels (e.g. charcoal) or electrical energy (e.g. ...
  7. CORESTA Congress, Kunming, 2018, Smoke Science/Product Technology Groups, STPOST 13 (also presented at TSRC 2018)

    Genotoxicity evaluation of tobacco and nicotine delivery products: Part 1. Mouse lymphoma assay

    LEVERETTE R.(1); THORNE D.(2); BREHENY D.(2); FOWLER K.(1); McENANEY S.(3); LLOYD M.(3); CLEMENTS J.(3); BOMBICK B.(1); GACA M.(2)
    (1) RAI Services Company, Scientific & Regulatory Affairs, Winston-Salem, NC, U.S.A.; (2) British American Tobacco (Investments) Ltd., Southampton, U.K.; (3) Covance Laboratories Ltd, Harrogate, North Yorkshire, U.K.
    In vitro studies have been widely used to support the toxicological evaluation of chemicals and complex mixtures including cigarette smoke. In this study a variety of test matrices from different tobacco and nicotine delivery products was assessed against ...
  8. CORESTA Congress, Kunming, 2018, Smoke Science/Product Technology Groups, STPOST 14 (also presented at TSRC 2018)

    Genotoxicity evaluation of tobacco and nicotine delivery products: Part 2. In Vitro micronucleus assay

    LEVERETTE R.(1); THORNE D.(2); BREHENY D.(2); FOWLER K.(1); McENANEY S.(3); WHITWELL J.(3); CLEMENTS J.(3); BOMBICK B.(1); GACA M.(2)
    (1) RAI Services Company, Scientific & Regulatory Affairs, Winston-Salem, NC, U.S.A.; (2) British American Tobacco (Investments) Ltd., Southampton, U.K.; (3) Covance Laboratories Ltd, Harrogate, North Yorkshire, U.K.
    In vitro studies have been widely used to support toxicological evaluations of chemicals and complex mixtures including cigarette smoke. In this study a variety of test matrices from tobacco and nicotine delivery products were assessed against a 3R4F ...
  9. CORESTA Congress, Kunming, 2018, Smoke Science/Product Technology Groups, STPOST 50

    A risk-based approach for the validation of bespoke smoking analyser software

    JONES J.; PRASAD K.; SLAYFORD S.; GRAY A.; MACRAE C.; THOMPSON C.
    British American Tobacco (Investments) Limited, Group R&D, Southampton, U.K.
    Background: The Smoking Analyser 7 (SA7), a device for measuring consumer’s puffing topography and mouth-level exposure, has been used extensively by British American Tobacco (BAT) since 1999. Due to the ever-changing nature of technology and the ...