Search Results

14 results

  1. CORESTA Congress, Kunming, 2018, Agronomy/Phytopathology Groups (Workshop), APW 06

    Modification of tobacco chemical constituents by molecular breeding

    LEWIS R.S.; DEWEY R.E.
    North Carolina State University, Department of Crop & Soil Sciences, Raleigh, NC, U.S.A.
    Tobacco plant chemistry affects consumer perception of derived products and also the potential for health risks associated with their use. Some cured leaf chemical components contribute positively to taste and aroma, while others have negative impacts and ...
  2. CORESTA Congress, Kunming, 2018, Agronomy/Phytopathology Groups, AP 23

    Engineering tobacco plants to degrade the potential NNK precursor pseudooxynicotine

    DEWEY R.E.; LEWIS R.S.; SELOTE D.
    North Carolina State University, Dept. of Crop and Soil Sciences, Raleigh, NC, U.S.A.
    Tobacco-specific nitrosamines (TSNAs) form when nitrous oxide species react with tobacco alkaloids. Although most published literature simplistically credits nicotine as being the alkaloid precursor for the potent TSNA NNK [4-(methyl nitrosoamino)-1-(3 ...
  3. CORESTA Congress, Kunming, 2018, Agronomy/Phytopathology Groups, AP 24

    Downregulation of a putative nitrate transporter gene substantially reduces the accumulation of TSNAs in air-cured tobaccos

    GOEPFERT S.(1); BOVET L.(1); LU J.(2); CAMPANONI P.(1); LEWIS R.S.(2); DEWEY R.E.(2)
    (1) Philip Morris Products S.A. (part of Philip Morris International group of companies), PMI R&D, Neuchâtel, Switzerland; (2) North Carolina State University, Department of Crop Science, Raleigh, NC, U.S.A.
    Air-cured Burley tobacco leaves typically exhibit high levels of nicotine-derived nitrosamine ketone (NNK) and N'-nitrosonornicotine (NNN). It has been previously demonstrated that leaf nitrate accumulation in air-cured tobaccos serves as the source ...
  4. TSRC, Tob. Sci. Res. Conf., 2017, 71, abstr. 070

    Genetic approaches and resources for enabling compliance to proposed NNN standards

    DEWEY R.E.(1); LEWIS R.S.(1); LU Jianli(1); BOVET L.(2); GOEPFERT S.(2); CAMPANONI P.(2)
    (1) North Carolina State University, Raleigh, NC, USA; (2) Philip Morris International, Neuchatel, Switzerland
    Tobacco-specific nitrosamines (TSNAs) are formed through the nitrosation of tobacco alkaloids. Over the past decade, we have demonstrated how altering the genetics of the tobacco plant can result in dramatic reductions in TSNA formation. This has been ...
  5. CORESTA Congress, Quebec, 2014, Agronomy/Phytopathology Groups, AP 01

    Reducing TSNAs in Burley tobaccos through alteration of the N-assimilation pathway

    DEWEY R.E.; LU J.; LEWIS R.S.; ZHANG L.
    North Carolina State University, Raleigh, NC, U.S.A.
    There is great interest in lowering the levels of tobacco-specific nitrosamines (TSNAs) in tobacco products. Because air-cured Burley tobaccos generally contribute a disproportionate share of TSNAs in typical “American blend” cigarettes, reducing the TSNA ...
  6. TSRC, Tob. Sci. Res. Conf., 2014, 68, abstr. 03

    Molecular biology-based approaches for facilitating compliance of future tobacco products in an FDA regulatory environment

    DEWEY R.E.; LEWIS R.S.
    North Carolina State University, Raleigh, North Carolina, USA
    Passed in 2009, the Family Smoking Prevention and Tobacco Control Act granted the U.S. Food and Drug Administration (FDA) the authority to regulate tobacco products. Among the powers given the FDA in this landmark legislation was the authority to define ...