Search Results

506 results

  1. CORESTA Meeting, Agronomy/Phytopathology, 2019, Victoria Falls, AP 14

    Field tests of loss-of-function tobacco lines of eIF(iso)4E for resistance to tobacco bushy top disease and agronomic traits

    KOGA K.(1); SHINJO A.(1); MAINJENI C.E.D.(2); MSANGOSOKO K.R.(2); UDAGAWA H.(1); TAKAKURA Y.(1)
    (1) Japan Tobacco Inc., Leaf Tobacco Research Center, Oyama, Tochigi, Japan; (2) Agricultural Research and Extension Trust, Department of Research and Technical Services, Lilongwe, Malawi
    Tobacco bushy top disease (TBTD) is one of the serious diseases affecting tobacco (Nicotiana tabacum L.) production in African countries such as Malawi, Zambia, Tanzania and Ethiopia. This disease is caused by a mixed infection of tobacco bushy top virus ...
  2. CORESTA Meeting, Agronomy/Phytopathology, 2019, Victoria Falls, APPOST 13

    Agronomic and qualitative performance of some experimental Burley hybrids in Malawi

    CHAMANGO A.M.Z.; SIBANDE L.A.G.O.; MATEWELE M.
    Agricultural Research and Extension Trust (ARET), Lilongwe, Malawi
    Malawi mainly depends on tobacco for forex generation, with Burley as a major contributor. However, the country has a limited choice of high yielding and disease resistant varieties against a plethora of disease constraints, particularly root-knot ...
  3. CORESTA Meeting, Agronomy/Phytopathology, 2019, Victoria Falls, APPOST 14

    Forestry sustainability in the tobacco sector in Malawi: a community concern requiring community approaches

    OFESI H.K.T.; LIVIMBO S.S.
    Agricultural Research and Extension Trust (ARET), Lilongwe, Malawi
    Tobacco farmers depend heavily on tree resources for poles and firewood used in curing. Malawi tobacco farmers predominantly grow Burley tobacco which requires the least amount of tree resources per unit volume in comparison to dark-fired and flue-cured ...
  4. CORESTA Meeting, Smoke Science/Product Technology, 2019, Hamburg, ST 12

    Review of current methodologies in evaluating abuse liability of nicotine and tobacco products in the U.S. regulatory environment

    EVANS S.(1); KONG M.C.(2); CAMPBELL L.(2); SHERWOOD N.(3); PRASAD K.(4)
    (1) Turning Point Brands, Louisville, KY, U.S.A.; (2) Altasciences Clinical Research, Laval, Canada; (3) Neil Sherwood Consulting, Nyon, Switzerland; (4) British American Tobacco, R&D, Millbrook, Southampton, U.K.
    Traditional definitions of abuse and misuse do not apply to a consumer product such as tobacco that consumers essentially use ‘as intended’. In contrast to pharmaceutical products, a guidance for abuse liability testing of nicotine and tobacco products ...
  5. CORESTA Meeting, Smoke Science/Product Technology, 2019, Hamburg, ST 29

    Thermochemical and thermophysical mapping of burning superslim and kingsize cigarettes

    EHLERT S.(1,3); CUI H.(2); HEIDE J.(3); XIE F.(2); DENG N.(2); LIU C.(4); McADAM K.(4); WALTE A.(1); ZIMMERMANN R.(3)
    (1) Photonion GmbH, Schwerin, Germany; (2) Zhengzhou Tobacco Research Institute of CNTC, Zhengzhou, Henan, P.R. China; (3) University of Rostock, Dept. of Analytical Chemistry, Rostock, Germany; (4) British American Tobacco, R&D Centre, Southampton, U.K.
    After presenting and publishing the proof of principle of the in-situ thermochemical and thermophysical mapping inside a burning Super Slim (SS) cigarette, we now extended the study scope to other cigarette formats and smoking regimes [1]. A Chinese ...
  6. CORESTA Meeting, Smoke Science/Product Technology, 2019, Hamburg, ST 44

    Lung biomarkers of harm/effect for tobacco regulatory research: opportunities and challenges – a literature review

    MAKENA P.(1); EDMISTON J.(2); BEATTIE E.(3); MASON E.(4); McEWAN M.(5); PRASAD K.(5)
    (1) RAI Services Company, Winston-Salem, NC, U.S.A.; (2) Altria Client Services LLC, Richmond, VA, U.S.A.; (3) Cliantha Research Limited, Canada; (4) Imperial Brands PLC, Bristol, U.K.; (5) British American Tobacco (Investments) Limited, Southampton, U.K.
    Biomarkers of potential harm (BoPH) are indicators of biological perturbations in response to smoking, which may contribute to smoking-related disease. In this review, a project of the CORESTA Biomarkers Sub-Group, we critically assessed the available ...
  7. CORESTA Meeting, Smoke Science/Product Technology, 2019, Hamburg, ST 54

    Clinical biomarkers of compliance for use in potentially reduced-risk product switching studies

    McEWAN M.(1); GALE N.(1); HARDIE G.(1); SCHERER M.(2); PLUYM N.(2); EBAJEMITO J.K.(1); CAMACHO O.M.(1); GRIFFITHS A.(1); PROCTOR C.J.(1)
    (1) British American Tobacco (Investments) Limited, Research and Development, Southampton, U.K.; (2) ABF GmbH, Planegg, Germany
    Preclinical assessments and clinical studies have shown significant reductions in toxicants in tobacco heating product (THP) aerosols compared to smoke from conventional cigarettes. Further studies to assess if these toxicant reductions translate to ...
  8. CORESTA Meeting, Smoke Science/Product Technology, 2019, Hamburg, STPOST 28

    The in vitro biological assessment of a tobacco heating product and comparison with cigarette smoke

    TAYLOR M.; BREHENY D.; ADAMSON J.; BOZHILOVA S.; JAUNKY T.; SANTOPIETRO S.; TERRY A.; THORNE D.; GACA M.
    British American Tobacco, Southampton, U.K.
    Cigarette smoking is a risk factor for many diseases including cardiovascular disease, lung disease, and cancer. Recently there has been an increase in the development and consumer acceptance of novel nicotine and tobacco products including tobacco ...
  9. CORESTA Meeting, Smoke Science/Product Technology, 2019, Hamburg, STPOST 29

    Reversibility of in vitro biological effects in cigarette smoke-exposed 3D lung tissues following switching to a tobacco heating product

    HASWELL L.E.; BREHENY D.; CORKE S.; JAUNKY T.; SANTOPIETRO S.; BAXTER S.; MINET E.; THORNE D.; GACA M.
    British American Tobacco, Southampton, U.K.
    Tobacco heated products (THPs) potentially offer a safer alternative to combustible cigarettes. Recent in vitro studies have shown reduced THP biological effects compared to 3R4F reference cigarette smoke. Existing in vitro data, however, has been ...
  10. CORESTA Meeting, Smoke Science/Product Technology, 2019, Hamburg, STPOST 30

    In vitro RNA-seq-based toxicogenomics assessment shows reduced biological effect of tobacco heating products when compared to cigarette smoke

    MEREDITH S.; HASWELL L.E.; CORKE S.; VERRASTRO I.; BAXTER A.; BANERJEE A.; ADAMSON J.; JUANKY T.; PROCTOR C.J.; MINET E.; GACA M.
    British American Tobacco, Southampton, U.K.
    The battery of regulatory tests used to evaluate the risk of novel tobacco products such as heated tobacco products (THPs) presents some limitations including a bias towards the apical endpoints tested, and limited information on the mode of action. This ...