Search Results

99 results

  1. CORESTA Meeting, Smoke Science/Product Technology, 2019, Hamburg, ST 18

    Human precision-cut lung slices as a screening tool: increased throughput, cryopreservation, and detection of DNA adducts for next generation tobacco product evaluation

    BEHRSING H.P.(1); DESAI P.(1); AMIN K.(2); BALBO S.(3); HECHT S.S.(2); SHEEHAN D.(1); CASTRO N.(1); ALLEN D.(4)
    (1) Institute for In Vitro Sciences, Inc., Gaithersburg, MD, U.S.A.; (2) University of Minnesota, Division of Environmental Health Sciences, Minneapolis, MN, U.S.A.; (3) University of Minnesota, Department of Laboratory Medicine and Pathology, Minneapolis, MN, U.S.A.; (4) Integrated Laboratory Systems, Inc., Morrisville, NC, U.S.A.
    Human-relevant, in vitro/ex vivo assays are considered an ethical and economically viable manner by which to screen the many chemicals requiring hazard assessment, such as next generation tobacco product (NGTP) ingredients. Human precision-cut lung slices ...
  2. CORESTA Meeting, Smoke Science/Product Technology, 2019, Hamburg, STPOST 36

    Use of ex vivo precision-cut lung slices as a screening tool for potential respiratory toxicity of e-liquids

    BEHRSING H.P.(1); SHEEHAN D.(1); AMIN K.(2); LEE K.M.(3); OLDHAM M.(4); RAABE H.(1)
    (1) Institute for In Vitro Sciences, Inc., Gaithersburg, MD, U.S.A.; (2) University of Minnesota, Minneapolis, MN, U.S.A.; (3) Altria Client Services, Richmond, VA, U.S.A.; (4) former Altria Client Services employee
    The Family Smoking Prevention and Tobacco Control Act gave the FDA regulatory authority over next generation tobacco products (NGTP) such as e-vapor products. E-vapor product liquids contain a variety of ingredient combinations that should be assessed for ...
  3. CORESTA Meeting, Smoke Science/Product Technology, 2019, Hamburg, STPOST 47

    Identification, discussion and recommendations for the optimal generation and use of in vitro genotoxicity assay data for tobacco and nicotine products

    DESAI P.(1); CURREN R.(1); MOORE M.M.(2)
    (1) Institute for In Vitro Sciences, Gaithersburg, MD, U.S.A.; (2) Ramboll Environ Inc., Little Rock, AR, U.S.A.
    The Institute for In Vitro Sciences is sponsoring a series of workshops to identify, discuss and develop recommendations for optimal scientific/technical approaches for utilizing in vitro regulatory genotoxicity assay data within and across tobacco and ...
  4. TSRC, Tob. Sci. Res. Conf., 2019, 73, abstr. 008

    Workshop series to identify, discuss and develop recommendations for the optimal generation and use of in vitro genotoxicity assay data for tobacco and nicotine products

    MOORE M.M.(1); CURREN R.(2)
    (1) Ramboll US Corporation, Little Rock, AR, USA; (2) Institute for In Vitro Sciences, Gaithersburg, MD, USA
    The Institute for In Vitro Sciences is sponsoring a series of workshops to identify, discuss and develop recommendations for optimal scientific/technical approaches for utilizing in vitro regulatory genotoxicity assay data within and across tobacco and ...
  5. CORESTA Congress, Berlin, 2016, Agronomy/Phytopathology Groups, AP 54

    The regulation of autophagy of susceptible Nicotiana tabacum under tobacco mosaic virus infection

    YANG Jinguang(1); LIU Xaingfu(1); LIU Wei(1); QIAN Yumei(1); ZHANG Jing(2); LI Wei(2); DONG Shifei(2); WANG Yaofeng(3); HUANG Mingdi(4); WANG Fenglong(1)
    (1) Tobacco Research Institute, Chinese Academy of Agricultural Sciences, Key Laboratory of Tobacco Pest Monitoring Controlling & Integrated Management, Qingdao, P.R. China; (2) Hongyun Honghe Tobacco (Group) Co., Ltd., Kunming, P.R. China; (3) Qingyang Branch of Gansu Province Tobacco Company, Xifeng, P.R. China; (4) Longnan Tobacco Company, Gansu Tobacco Cooperation, Wudu 746000, P.R. China
    Autophagy (or self-eating) is an important conserved process by which eukaryotic cells recycle intracellular components. This study was undertaken to elucidate whether tobacco mosaic virus (TMV) infection on tobacco plants induced autophagy. TMV-U1 and ...
  6. CORESTA Congress, Berlin, 2016, Smoke Science/Product Technology Groups, STPOST 33

    Accurate and reproducible dispensing of patterned picoliter quantities of tobacco extract onto apical surfaces of human 3D reconstructed airway tissues

    BEHRSING H.(1); SADOWSKI N.(1); CONSTANT S.(2); HUANG S.(2); RAABE H.(1)
    (1) Institute for In Vitro Sciences, Inc., Gaithersburg, MD, U.S.A.; (2) Epithelix Sàrl, Geneva, Switzerland
    There is an increasing need for researchers to understand the dynamic aspects of inhaled tobacco product exposure. Exposure-induced events can cause respiratory irritation, sensitisation, and other events that may lead to severe pulmonary disease. ...
  7. CORESTA Meeting, Smoke Science/Product Technology, 2015, Jeju, ST 27

    Analysis of process intensity on tobacco moisture retention based on uniform design

    LI Wenjuan(1); ZHOU Fangfang(1); LONG Minghai(1); ZI Wenhua(1); JIANG Meihong(1); LIU Ze(2)
    (1) Yunnan Reascend Tobacco Technology (Group) Co., Ltd., Kunming, Yunnan, P.R. China; (2) Hongyun Honghe Group, Kunming, Kunming, P.R. China
    Tobacco moisture retention provides essential information about moisture adsorption behaviour and physical characteristics of cigarette formulating, which also influence cigarette aroma and smoking quality. Effect of the intensity of the casing process on ...
  8. TSRC, Tob. Sci. Res. Conf., 2015, 69, abstr. 109

    3d reconstructed human airway models: effect of acclimation conditions on biomarker and inflammatory response following tissue challenge

    BEHRSING H.; RAABE H.A.; SHEEHAN D.W.; SLY E.A.; CURREN R.D.
    Institute for In Vitro Sciences, Gaithersburg, MD USA
    Human reconstructed, 3-dimensional (3D) airway tissues present researchers with organotypic models that consist of heterogenous cell types that more accurately reflect the pulmonary airway in vivo. These in vitro models are now increasingly applied to ...
  9. TSRC, Tob. Sci. Res. Conf., 2015, 69, abstr. 86

    Study on influence of processing strength on flue-cured tobacco leaf quality in the threshing and redrying process

    LONG Minghai(1); HUA Yikun(2); WANG Xianguo(2); LIN Nan(1); ZI Wenhua(1)
    (1) Yunnan Reascend Tobacco Technology (Group) Co. Ltd., Kunming, Yunnan, P.R. China; (2) Hongyun Honghe (Group) Co., Ltd., Kunming, Yunnan, P.R. China
    To improve the technological level of threshing and redrying and quality of products, the influences of processing strengths (steam moistening, steam mixing water moistening, slow redrying with low-temperature, high-temperature redrying) on the qualities ...
  10. CORESTA Congress, Quebec, 2014, Smoke Science/Product Technology Groups, ST 15

    Evaluation of the EpiOral™ reconstructed human oral buccal tissue model as a testing platform for determining the oral irritation potential of tobacco products

    RAABE H.; BARNES N.; HILBERER A.
    Institute for In Vitro Sciences, Inc., Gaithersburg, MD, U.S.A.
    There is an increasing need by the tobacco industry to evaluate the oral/buccal irritation potential of tobacco products both to support product development goals and for sound product stewardship. The use of in vitro human cell and tissue-based test ...