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107 results

  1. CORESTA Meeting, Smoke Science/Product Technology, 2019, Hamburg, STPOST 27

    Next generation product aerosol bubbled extracts show little to no effect in high content screening endpoints when compared to cigarette smoke bubbled extracts

    TRELLES STICKEN E.(1); WIECZOREK R.(1); BODE L.M.(1); SIMMS L.(2); STEVENSON M.(2)
    (1) Reemtsma Cigarettenfabriken GmbH (an Imperial Brands PLC Company), BioToxLab, Hamburg, Germany; (2) Imperial Tobacco Limited, In vitro Research, Bristol, U.K.
    Tobacco-based and tobacco-free next generation products (NGPs) are understood to be a less harmful alternative to conventional combustible cigarettes. The objective of this study was to compare the in vitro biological response of cigarette smoke...
  2. CORESTA Meeting, Smoke Science/Product Technology, 2019, Hamburg, STPOST 34

    Next generation product aerosols induce lower biological activity than combusted cigarettes: a comparison of in vitro cell migration in the scratch wound assay

    RUDD K.(1); BUDDE J.(2); TRELLES STICKEN E.(2); WIECZOREK R.(2); SIMMS L.(1); STEVENSON M.(1)
    (1) Imperial Brands PLC, Bristol, U.K.; (2) Reemtsma Cigarettenfabriken GmbH (an Imperial Brands PLC Company), Hamburg, Germany
    Smoking combustible cigarettes is a cause of serious diseases in smokers, including heart disease. There are many commercially available next generation products (NGPs), such as tobacco-free e-vapour products, aiming to provide an alternative to...
  3. CORESTA Meeting, Smoke Science/Product Technology, 2019, Hamburg, STPOST 37

    Use of cell media nicotine concentration as a marker to predict cells surface deposited nicotine in transwells after fresh smoke/aerosol exposure

    WIECZOREK R.(1); TRELLES STICKEN E.(1); BODE L.M.(1); SIMMS l.(2)
    (1) Reemtsma Cigarettenfabriken GmbH (an Imperial Brands PLC Company), Hamburg, Germany; (2) Imperial Tobacco Limited, Bristol, U.K.
    Exposure of organotypic 3D lung models at the air liquid interface (ALI) to fresh whole smoke/aerosol provides a more human relevant exposure assessment of combustible cigarettes and e-vapour products. The aim of this study is to present a method...
  4. CORESTA Meeting, Smoke Science/Product Technology, 2019, Hamburg, STW 01

    The application of in vitro Toxicity Testing in 21 Century (TT21C) for next generation products

    SIMMS L.(1); TRELLES STICKEN E.(2)
    (1) Imperial Brands PLC, Bristol, U.K.; (2) Reemtsma Cigarettenfabriken GmbH (an Imperial Brands PLC Company), Hamburg, Germany
    The aim is to demonstrate the feasibility of TT21C in vitro methods as part of an overall assessment framework for next generation products (NGP). TT21C methodologies can be used to assess harm reduction potential of NGPs using human-derived...
  5. TSRC, Tob. Sci. Res. Conf., 2019, 73, abstr. 086

    Determination of tobacco alkaloids in consumer products by UPLC-MS/MS using a modified quechers method

    SHIFFLETT J.R.; WITTENBERG J.B.; BEZABEH D.Z.
    Alcohol and Tobacco Tax and Trade Bureau, Beltsville, MD, USA
    The U.S. Alcohol and Tobacco Tax and Trade Bureau (TTB) is responsible for collecting Federal excise taxes on tobacco products. Tobacco products in the U.S. may fall into several taxable categories including cigars, cigarettes, snuff, chewing...
  6. TSRC, Tob. Sci. Res. Conf., 2017, 71, abstr. 061

    Simultaneous determination of tobacco alkaloids, tobacco specific nitrosamines, and solanesol in consumer products using UPLC-ESI-MS/MS

    SHIFFLETT J.R.; WATSON L.; McNALLY D.J.; BEZABEH D.Z.
    U.S. Treasury Department, Alcohol and Tobacco Tax and Trade Bureau, Beltsville, MD, USA
    The U.S. Alcohol and Tobacco Tax and Trade Bureau (TTB) is responsible for collecting Federal excise taxes on tobacco products. Tobacco products in the U.S. may fall into several taxable categories including cigars, cigarettes, snuff, chewing...
  7. CORESTA Congress, Berlin, 2016, Agronomy/Phytopathology Groups, AP 54

    The regulation of autophagy of susceptible Nicotiana tabacum under tobacco mosaic virus infection

    YANG Jinguang(1); LIU Xaingfu(1); LIU Wei(1); QIAN Yumei(1); ZHANG Jing(2); LI Wei(2); DONG Shifei(2); WANG Yaofeng(3); HUANG Mingdi(4); WANG Fenglong(1)
    (1) Tobacco Research Institute, Chinese Academy of Agricultural Sciences, Key Laboratory of Tobacco Pest Monitoring Controlling & Integrated Management, Qingdao, P.R. China; (2) Hongyun Honghe Tobacco (Group) Co., Ltd., Kunming, P.R. China; (3) Qingyang Branch of Gansu Province Tobacco Company, Xifeng, P.R. China; (4) Longnan Tobacco Company, Gansu Tobacco Cooperation, Wudu 746000, P.R. China
    Autophagy (or self-eating) is an important conserved process by which eukaryotic cells recycle intracellular components. This study was undertaken to elucidate whether tobacco mosaic virus (TMV) infection on tobacco plants induced autophagy. TMV-U1...
  8. CORESTA Congress, Berlin, 2016, Agronomy/Phytopathology Groups, APPOST 26

    Crop compliance: crop protection agents testing programme within purchases

    BODE L.M.; EVANS W.; INTORP M.
    Reemtsma Cigarettenfabriken GmbH (an Imperial Brands PLC Company), Hamburg, Germany
    In order to ensure the compliance of our products, leaf grade purchases are monitored for the presence of any residual crop protection agents (CPA). CPA residue levels are first assessed for compliance against limits set by regulatory authorities and...
  9. CORESTA Congress, Berlin, 2016, Smoke Science/Product Technology Groups, STPOST 04

    Impact of different vaping machines on metal contaminations of e-cigarette aerosols

    OTTE S.; NOWAK S.; INTORP M.
    Reemtsma Cigarettenfabriken GmbH (an Imperial Brands PLC Company), Hamburg, Germany
    The presence of trace metals in e-liquids or aerosol of electronic cigarettes (e-cigarette) has been previously reported[1]. It has also been demonstrated that contamination with tin, aluminum, copper, iron and nickel may occur from certain parts of...
  10. CORESTA Congress, Berlin, 2016, Smoke Science/Product Technology Groups, STPOST 10

    Analysis of the polyphenols of tobacco using pressurized liquid extraction (PLE) and ultra performance liquid chromatography with electrospray ionization – tandem mass spectrometric detection (UPLC-ESI-MS/MS)

    SHIFFLETT J.R.; WATSON L.; McNALLY D.J.; BEZABEH D.Z.
    United States Department of the Treasury, Alcohol and Tobacco Tax and Trade Bureau (TTB), Beltsville, MD, U.S.A.
    Tobacco curing is a drying process that is used to transform recently harvested tobacco leaves into material suitable for incorporation into consumer products such as cigars and cigarettes. Different types of tobacco (bright, Burley, Oriental, etc.)...