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  1. CORESTA Meeting, Smoke Science/Product Technology, 2013, Seville, STPOST 15

    A modified Ames methodology for the assessment of mainstream cigarette smoke genotoxicity using an aerosol-based exposure system

    THORNE D.(1); KILFORD J.(2); PAYNE R.(2); DALRYMPLE A.(1); CLEMENTS J.(2); MEREDITH C.(1); DILLON D.(1)
    (1) British American Tobacco, Group R&D, Southampton, Hampshire, U.K.; (2) Covance Laboratories Ltd, Harrogate, North Yorkshire, U.K.
    To date most toxicological testing of cigarettes has been performed on the particulate phase of cigarette smoke using standard genotoxic and cytotoxic methods, which include the AMES reverse mutation assay, neutral red uptake, mouse lymphoma and ...