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158 results

  1. CORESTA Congress, Kunming, 2018, Smoke Science/Product Technology Groups, ST 56

    Photoionization time-of-flight mass spectrometry as a tool for the identification of selected isomers in the gas phase of mainstream cigarette smoke

    HU Yonghua(1); WANG Jian(1); TIAN Zhenfeng(1); CHEN Kaibo(1); XU Yingbo(1); PAN Yang(2)
    (1) Technology Center, China Tobacco Anhui Industrial Co., Ltd., Hefei, Anhui, P.R. China; (2) National Synchrotron Radiation Laboratory, University of Science and Technology of China, Hefei, Anhui, P.R. China
    To identify selected isomers in the gas phase of mainstream cigarette smoke, an on-line measurement system with a photoionization unit was built. With this instrument, photoionization efficiency (PIE) curves for constituents in the gas phase of mainstream ...
  2. CORESTA Congress, Kunming, 2018, Smoke Science/Product Technology Groups, STPOST 12 (also presented at TSRC 2018)

    Characterization of the Vitrocell® high throughput exposure modules using different tobacco product types

    LEVERETTE R.(1); KEYSER B.(2); SEYMOUR A.(2); HOLLINGS M.(2); BOMBICK B.(1)
    (1) RAI Services Company, Scientific & Regulatory Affairs, Winston-Salem, NC, U.S.A.; (2) Covance Laboratories Ltd, Harrogate, North Yorkshire, U.K.
    The development of whole smoke/aerosol exposure systems provides a means to conduct in vitro assessment of freshly generated whole smoke and aerosol from combustible and tobacco heating products (THP) as well as electronic nicotine delivery systems (ENDS) ...
  3. CORESTA Congress, Kunming, 2018, Smoke Science/Product Technology Groups, STPOST 13 (also presented at TSRC 2018)

    Genotoxicity evaluation of tobacco and nicotine delivery products: Part 1. Mouse lymphoma assay

    LEVERETTE R.(1); THORNE D.(2); BREHENY D.(2); FOWLER K.(1); McENANEY S.(3); LLOYD M.(3); CLEMENTS J.(3); BOMBICK B.(1); GACA M.(2)
    (1) RAI Services Company, Scientific & Regulatory Affairs, Winston-Salem, NC, U.S.A.; (2) British American Tobacco (Investments) Ltd., Southampton, U.K.; (3) Covance Laboratories Ltd, Harrogate, North Yorkshire, U.K.
    In vitro studies have been widely used to support the toxicological evaluation of chemicals and complex mixtures including cigarette smoke. In this study a variety of test matrices from different tobacco and nicotine delivery products was assessed against ...
  4. CORESTA Congress, Kunming, 2018, Smoke Science/Product Technology Groups, STPOST 14 (also presented at TSRC 2018)

    Genotoxicity evaluation of tobacco and nicotine delivery products: Part 2. In Vitro micronucleus assay

    LEVERETTE R.(1); THORNE D.(2); BREHENY D.(2); FOWLER K.(1); McENANEY S.(3); WHITWELL J.(3); CLEMENTS J.(3); BOMBICK B.(1); GACA M.(2)
    (1) RAI Services Company, Scientific & Regulatory Affairs, Winston-Salem, NC, U.S.A.; (2) British American Tobacco (Investments) Ltd., Southampton, U.K.; (3) Covance Laboratories Ltd, Harrogate, North Yorkshire, U.K.
    In vitro studies have been widely used to support toxicological evaluations of chemicals and complex mixtures including cigarette smoke. In this study a variety of test matrices from tobacco and nicotine delivery products were assessed against a 3R4F ...
  5. CORESTA Congress, Kunming, 2018, Smoke Science/Product Technology Groups, STPOST 26

    Determination of carbonyl compounds in gas vapour phase in phosphate buffered saline by LC-MS/MS for use with traditional tobacco and electronic nicotine delivery system (ENDS) products

    HOLLINGS M.(1); SEYMOUR A.(1); LYNCH A.(2); LARNER J.(1); CLEMENTS J.(1); HENDERSON L.(2)
    (1) Covance Laboratories Limited, Harrogate, U.K.; (2) Broughton Laboratories Ltd, Skipton, U.K.
    The purpose of this study was to develop a liquid chromatography tandem mass spectrometry (LC-MS/MS) method to quantify selected carbonyl compounds (formaldehyde, acetaldehyde, crotonaldehyde, acrolein, acetone, butyraldehyde, 2-butanone (MEK) ...
  6. CORESTA Congress, Kunming, 2018, Smoke Science/Product Technology Groups, STPOST 51

    Simultaneous measurement of cilia beat frequency, goblet cell hyperplasia and TEER endpoints in EpiAirway™-FT treated tissues may reveal underlying toxicity mechanisms in vitro

    WOODHAMS A.(1); KIDD D.(1); DAUNT A.(2); POSTOYALKO A.(2); HOLLINGS M.(1)
    (1) Department of Genetic Toxicology, Covance Laboratories Ltd, Harrogate, U.K.; (2) Special Pathology Services, Covance Laboratories Limited, Harrogate, U.K.
    The EpiAirway™-FT (full thickness) tissues (Mattek Corporation, Ashland, USA) contain tight junctions, ciliated and other bronchial cell types making it an ideal model for testing aerosolised substances in vitro. Toxicity is not a single endpoint but a ...
  7. TSRC, Tob. Sci. Res. Conf., 2018, 72, abstr. 014 (also presented at CORESTA 2018)

    Genotoxicity evaluation of tobacco and nicotine delivery products: Part 1. Mouse lymphoma assay

    LEVERETTE R.(1); BOMBICK B.(1); FOWLER K.(1); BREHENY D.(2); GACA M.(2); THORNE D.(2); CLEMENTS J.(3); LLOYD M.(3); McENANEY S.(3)
    (1) RAI Services Company, Winston-Salem, NC, USA; (2) British American Tobacco (Investments) Ltd., Southampton, UK; (3) Covance Laboratories Ltd, Harrogate, UK
    In vitro studies have been widely used to support the toxicological evaluation of chemicals and complex mixtures including cigarette smoke. In this study a variety of test matrices from different tobacco and nicotine delivery products was assessed against ...
  8. TSRC, Tob. Sci. Res. Conf., 2018, 72, abstr. 015 (also presented at CORESTA 2018)

    Genotoxicity evaluation of tobacco and nicotine delivery products: Part 2. In vitro micronucleus assay

    LEVERETTE R.(1); BOMBICK B.(1); FOWLER K.(1); BREHENY D.(2); GACA M.(2); THORNE D.(2); CLEMENTS J.(3); McENANEY S.(3); WHITWELL J.(3)
    (1) RAI Services Company, Winston-Salem, NC, USA; (2) British American Tobacco (Investments) Ltd., Southampton, UK; (3) Covance Laboratories Ltd, Harrogate, UK
    In vitro studies have been widely used to support toxicological evaluations of chemicals and complex mixtures including cigarette smoke. In this study a variety of test matrices from tobacco and nicotine delivery products were assessed against a 3R4F ...
  9. TSRC, Tob. Sci. Res. Conf., 2018, 72, abstr. 016 (also presented at CORESTA 2018)

    Characterization of the Vitrocell® high throughput exposure modules using different tobacco product types

    LEVERETTE R.(1); KEYSER B.(1); BOMBICK B.(1); HOLLINGS M.(2); SEYMOUR A.(2)
    (1) RAI Services Company, Winston-Salem, NC, USA; (2) Covance Laboratories Ltd, Harrogate, UK
    The development of whole smoke/aerosol exposure systems provides a means to conduct in vitro assessment of freshly generated whole smoke and aerosol from combustible and tobacco heating products (THP) as well as electronic nicotine delivery systems (ENDS) ...