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309 results

  1. TSRC, Tob. Sci. Res. Conf., 2021, 74, abstr. 32

    Development of recommendations of descriptive consumer-reported outcome measures (descriptive-CROM) and related definitions in tobacco and nicotine research

    WEI L.(1) on behalf of CORESTA CROM Task Force: CLERC E.(2); SHETTY M.(3); CHREA C.(2); PRASAD K.(3); SARKAR M.(1)
    (1) Altria Client Services LLC, Richmond, VA, USA; (2) Philip Morris International, Neuchâtel, Switzerland; (3) British American Tobacco, Southampton, UK
    Background: The Consumer Reported Outcome Measures (CROM) Consortium Task Force (TF), consisting of academic researchers and members from various tobacco companies, was formed within the Cooperation Centre for Scientific Research Relative to Tobacco...
  2. CORESTA Congress, Online, 2020, Smoke Science/Product Technology Groups, ST 17

    The dos and don’ts of non-targeted screening by LC–HRAM-MS for chemical characterization of smoke-free products

    WACHSMUTH C.; ARNDT D.; BUCHHOLZ C.; BENTLEY M.; GOUJON-GINGLINGER C.
    Philip Morris Products S.A., PMI R&D, Neuchâtel, Switzerland
    Liquid chromatography coupled to high-resolution accurate-mass spectrometry (LC–HRAM-MS)-based non-targeted screening (NTS) is a key methodology for characterizing the chemical composition of complex matrices. It enables simultaneous identification...
  3. CORESTA Congress, Online, 2020, Smoke Science/Product Technology Groups, ST 18

    Computer-assisted structure identification (CASI) for high-throughput identification of small molecules by GC×GC–HRAM-TOFMS

    KNORR A.; ALMSTETTER M.; MARTIN E.; CASTELLON A.; POSPISIL P.; BENTLEY M.; GOUJON C.
    Philip Morris Products S.A., PMI R&D, Neuchâtel, Switzerland
    Compound identification is widely recognized as a major bottleneck in modern metabolomic approaches and high-throughput non-targeted characterization of complex matrices. An automated platform CASI (computer-assisted structure identification) was...
  4. CORESTA Congress, Online, 2020, Smoke Science/Product Technology Groups, ST 19

    Non-targeted chemical characterization of complex matrices by nominal- and high-resolution accurate-mass GC×GC–TOFMS

    ALMSTETTER M.; KNORR A.; RHOUMA M.; MARTIN E.; CASTELLON A.; POSPISIL P.; BENTLEY M.; GOUJON C.
    Philip Morris Products S.A., PMI R&D, Neuchâtel, Switzerland
    Comprehensive chemical characterization is an important element in the development of heat-not-burn products. Beyond the challenge of developing powerful analytical methods with sufficient chromatographic and spectral resolution, it is essential to...
  5. CORESTA Congress, Online, 2020, Smoke Science/Product Technology Groups, ST 21

    Untargeted chemical characterization of the aerosol generated by a heated tobacco product

    BENTLEY M.; ALMSTETTER M.; ARNDT D.; KNORR A.; MARTIN E.; POSPISIL P.; MAEDER S.
    Philip Morris Products S.A., PMI R&D, Neuchâtel, Switzerland
    In contrast to quantitative analysis, where chemical constituents of interest are targeted to the exclusion of all others, an untargeted approach considers indiscriminate determination of all analytes relevant to a specific chemical space. A...
  6. CORESTA Congress, Online, 2020, Smoke Science/Product Technology Groups, ST 24

    Dos and don’ts in the design of indoor air quality studies on smoke-free products

    MITOVA M.I.; GOUJON-GINGLINGER C.; GOMEZ LUESO M.; ROTACH M.; MAEDER S.
    Philip Morris Products S.A., PMI R&D, Neuchâtel, Switzerland
    Indoor air quality (IAQ) studies on smoke-free products (SFPs), such as electrically heated tobacco products (EHTPs) and e-vapour products (EVPs), have demonstrated substantial reduction of environmental emissions relative to cigarette smoking. IAQ...
  7. CORESTA Congress, Online, 2020, Smoke Science/Product Technology Groups, ST 26

    Comparative risk assessment of heated tobacco product and electronic cigarette aerosols with cigarette smoke based on cancer potency and margin of exposure

    RODRIGO G.; JACCARD G.; TAFIN DJOKO D.; KORNELIOU A.; ESPOSITO M.; BELUSHKIN M.
    Philip Morris Products S.A., PMI R&D, Neuchâtel, Switzerland
    An average reduction of more than 90 % in concentrations of harmful and potentially harmful constituents (HPHCs; among given lists) has been observed in the aerosols of commercial heated tobacco products (HTPs) and electronic cigarettes (ECs)...