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3 results

  1. CORESTA Congress, Berlin, 2016, Smoke Science/Product Technology Groups, STPOST 31

    Improvement of in-situ slide preparation procedure for semi-automated micronucleus counting system

    ERAMI K.(1); SAWAMOTO Y.(1); YOSHINO K.(1); SOFUNI T.(2)
    (1) Japan Tobacco Inc., Scientific Product Assessment Center, Yokohama, Kanagawa, Japan; (2) Genotoxic Consulting Services, Shiraoka, Saitama, Japan
    In-situ micronucleus (MN) test is an easier-to-use procedure than the traditional way such as a dish preparing approach. Nevertheless, the amount of resources needed for manual counting and the necessity of advanced preparations for reaching consensus of ...
  2. CORESTA Congress, Paris, 2006, SSPOST 17

    Skin-painting studies of cigarette smoke condensate in SENCAR mice for evaluating effect on tumor promotion of cigarette with ingredients

    NAKAMURA H.; YOSHINO K.; FUJI S.; ISHII I.; LULHAM G.W.; HEJTMANCIK M.; KOESTER A.; YOSHIMURA H.
    Japan Tobacco Inc., Tokyo, Japan
    Four SENCAR mouse dermal studies were conducted with cigarette smoke condensate (CSC) preparations to evaluate the effect on tumor promotion of Test Cigarettes with ingredients compared with a Reference Cigarette. Each independent study used a unique ...
  3. CORESTA Congress, Paris, 2006, SSPOST 18

    Comparative inhalation toxicity of test cigarettes containing ingredients and a reference cigarette in rats

    YOSHINO K.; FUJI S.; ISHII I.; LULHAM G.W.; LEE K.M.; RENNE R.A.; WAKO K.; TSUCHITANI M.; YOSHIMURA H.
    Japan Tobacco Inc., Tokyo, Japan
    Two 90-day rodent inhalation toxicity studies were conducted to investigate the potential effects of 253 ingredients when added as subsets of 62, 67, 61 and 63 ingredients to the tobacco blend used for the manufacture of reference cigarettes. The overall ...