Search Results

69 results

  1. CORESTA Meeting, Smoke Science/Product Technology, 2019, Hamburg, STPOST 11 (also presented at TSRC 2019)

    Simultaneous determination analysis of glycerol, propylene glycol, nicotine, menthol and water by discharge ionisation detector on gas chromatography

    SHIMAZU A.; OMORI F.
    Japan Tobacco Inc., Product Quality Research Center, Tokyo, Japan
    CORESTA developed a recommended method (CRM 84) for determination of Glycerin (G), Propylene Glycol (PG), nicotine and water in the aerosol of e-cigarettes by gas chromatography (GC) with flame ionisation detector (FID) and thermal conductivity...
  2. CORESTA Meeting, Smoke Science/Product Technology, 2019, Hamburg, STPOST 39

    Risk assessment of a novel tobacco vapour product using ToxTracker® assay and high content screening in vitro

    MUNAKATA S.; ERAMI K.; HASHIZUME T.
    Japan Tobacco Inc., R&D Group, Scientific Product Assessment Center, Yokohama, Kanagawa, Japan
    A novel tobacco vapour product (NTV) showed its lower genotoxic and cytotoxic potentials in the in vitro bacterial reverse mutation assay, micronucleus assay, and neutral red uptake assay compared with a combustible tobacco product. This study aimed...
  3. CORESTA Meeting, Smoke Science/Product Technology, 2019, Hamburg, STPOST 48

    Comparative study of Salmonella typhimurium tester strains TA1537, TA97 and TA97a in mutagenicity evaluation of tobacco products

    SAKAI Y.; ISHII T.; TAKAHASHI Y.; HASHIZUME T.; FUKUSHIMA T.
    Japan Tobacco Inc., Scientific Product Assessment Center, R&D Group, Yokohama, Kanagawa, Japan
    The Ames test has been conducted to examine the mutagenicity of tobacco products and to compare relative mutagenicity of cigarette smoke. The OECD TG 471 states that at least five tester strains should be used for the Ames test, and Salmonella...
  4. CORESTA Meeting, Smoke Science/Product Technology, 2019, Hamburg, STPOST 49

    The CORESTA in vitro test battery for combustible tobacco products: update from the 2004 Rationale and Strategy Report

    LEE K.M.(1); JORDAN K.G.(2); WIECZOREK R.(3); MOENNIKES O.(4); CLEMENTS J.(5); CROOKS I.(6); HASHIZUME T.(7); MILLER J.(8); WEBER E.(9); YOSHINO K.(7)
    (1) Altria Client Services, Richmond, VA, U.S.A.; (2) RAI Services Company, Winston-Salem, NC, U.S.A.; (3) Imperial Brands, Reemtsma Cigarettenfabriken GmbH, Hamburg, Germany; (4) PMI R&D, Philip Morris Products S.A., Neuchâtel, Switzerland; (5) Covance Laboratories Ltd, Harrogate, U.K.; (6) British American Tobacco (Investments) Ltd, R&D, Southampton, U.K.; (7) Japan Tobacco Inc., Yokohama, Kanagawa, Japan; (8) JT International SA, Geneva, Switzerland; (9) Ökolab, Vienna, Austria
    In 2004, the CORESTA In Vitro Toxicity Task Force issued a rationale and strategy report, commonly known as “the CORESTA in vitro test battery guideline”. The goals of this guideline were to: 1) develop the rationale and strategy for conducting in...
  5. CORESTA Meeting, Smoke Science/Product Technology, 2017, Kitzbühel, ST 27

    Pharmacokinetics of nicotine following the controlled use of a prototype novel tobacco vapour product

    YUKI D.(1,2); SAKAGUCHI C.(1); KIKUCHI A.(1); FUTAMURA Y.(1)
    (1) Japan Tobacco Inc., R&D Group, Scientific Product Assessment Center, Yokohama, Kanagawa, Japan; (2) JT International S.A., Scientific & Regulatory Affairs, Geneva, Switzerland
    The objective of this clinical study was to investigate the pharmacokinetics of nicotine following the use of a prototype novel tobacco vapour (PNTV) product in comparison to a conventional cigarette (CC1). The study was conducted in Japanese healthy...
  6. CORESTA Meeting, Smoke Science/Product Technology, 2017, Kitzbühel, ST 43

    Feasibility study of simultaneous determination of particulate and volatile compounds in mainstream cigarette smoke

    KUMAGAI A.; EGUCHI K.; FUKAI Y.
    Japan Tobacco Inc., Product Quality Research Center, Yokohama, Kanagawa, Japan
    This study demonstrates the feasibility of simultaneous determination of tobacco-specific nitrosamines (TSNAs) and volatile organic compounds (VOCs) in mainstream cigarette smoke. WHO TobReg has proposed mandated lowering of nine toxicants in...
  7. CORESTA Meeting, Smoke Science/Product Technology, 2017, Kitzbühel, ST 58

    Contribution of gas-phase combustion to total heat generation from a burning cigarette

    INOUE Y.(1); SUZUKI M.(2)
    (1) Japan Tobacco Inc., Tobacco Science Research Center, Yokohama, Kanagawa, Japan; (2) Nagaoka University of Technology, Nagaoka, Niigata, Japan
    Heat release is an important factor in understanding a burning cigarette. Heat releasing reactions are assumed to consist of three categories: pyrolysis, generating char and pyrolysis gas; combustion, generating combustion gas and residue; and...
  8. CORESTA Meeting, Smoke Science/Product Technology, 2017, Kitzbühel, ST 59

    Estimating the filling capacity of cut-rolled expanded stem (CRES) from Visible (Vis)–Near infrared (NIR) spectrum of stem

    SHIMIZU W.(1); ISHIHARA K.(1); YAGASHIRA T.(2)
    (1) Japan Tobacco Inc., Leaf Tobacco Research Center, Tochigi, Japan; (2) JT International Germany GmbH, Trier, Germany
    Filling capacity is an important physical characteristic for evaluating cut-rolled expanded stem (CRES) quality and for designing cigarettes. As presented at the CORESTA Congress 2012, we developed a calibration model between Vis-NIR spectra and...