1. CORESTA Congress, Berlin, 2016, Smoke Science/Product Technology Groups, ST 06

    Evaluation of a biomarker of oxidative stress: 8-iso-prostaglandin F2α / prostaglandin F2α ratio

    NEWLAND K.(1); MILLER P.(1); FARMEN R.(1); TRAN C.T.(2); HAZIZA C.(2); PICAVET P.(2)
    (1) Celerion, Inc., Lincoln, NE, U.S.A.; (2) Philip Morris Products S.A. (part of Philip Morris International group of companies), Neuchâtel, Switzerland
    It is understood that exposure to free radicals related to tobacco use negatively impacts smoker health. Studies have been performed measuring fatty acid oxidation products (F2-Isoprostanes) in human urine as biomarkers of harm from free radical exposure. ...
  2. CORESTA Congress, Berlin, 2016, Smoke Science/Product Technology Groups, ST 23

    Pharmacokinetics of nicotine following single controlled use of a new type of tobacco: heated tobacco product

    GILES L.(1); YUKI D.(2); SHERWOOD N.(3); GRAFF D.W.(4); NEWLAND K.(4)
    (1) JT International SA, Ballymena, Co. Antrim, U.K.; (2) Japan Tobacco Inc., Yokohama, Kanagawa, Japan; (3) Neil Sherwood Consulting, Commugny, Switzerland; (4) Celerion, Lincoln, NE, U.S.A.
    Nicotine is one of the most characteristic compounds contained in any type of tobacco product including cigarettes. Previous studies have reported that different types of tobacco products display differences in nicotine pharmacokinetics. NHTP is a new ...
  3. TSRC, Tob. Sci. Res. Conf., 2016, 70, abstr. 20

    Evaluation of a biomarker of oxidative stress: the 8-iso prostaglandin F2α: prostaglandin F2α ratio in human plasma

    MILLER P.(1); NEWLAND K.(1); DZERK A.(1); FARMEN R.(1); TRAN C.T.(2); HAZIZA C.(2); PICAVET P.(2)
    (1) Celerion, Inc., Lincoln, NE, USA; (2) Philip Morris International, Neuchâtel, Switzerland
    F2-isoprostanes have been widely studied as biomarkers of oxidative stress for various indications, including smoking. Since both enzymatic biosynthesis and chemical lipid peroxidation can generate these biomarkers, there are various interpretations that ...
  4. CORESTA Congress, Quebec, 2014, Smoke Science/Product Technology Groups, ST 72

    The analysis of isotopically labeled propylene glycol in e-cigarettes

    FARMEN R.H.; NEWLAND K.E.; NACHI R.; KAFONEK C.J.; ISLAM R.
    Celerion, Lincoln, NE 68502 U.S.A. & Celerion, Zürich, Switzerland
    Measurement of the excipients in e-cigarettes has become a hot topic of discussion with the release of the new draft guidance from the United States Food and Drug Administration (FDA). However difficulties in the selective measurement of the bioavailable ...
  5. CORESTA Meeting, Smoke Science/Product Technology, 2013, Seville, ST 22

    The statistical benefit of performing GLP bioanalysis using assays that have reduced variability

    FARMEN R.H.; NEWLAND K.E.; GRAFF D.W.; COMBS M.L.
    Celerion, Lincoln, NE, U.S.A.; Celerion, Zürich, Switzerland
    Since the tobacco industry is moving into the area of regulated bioanalysis, we have noted that there is confusion surrounding the type of regulatory standards required for analytical methods to be used for testing tobacco constituents and biomarkers in ...