1. CORESTA Meeting, Smoke Science/Product Technology, 2019, Hamburg, ST 19

    In vitro biological impact evaluation of whole cigarette smoke by using pathway-based approach

    CHEN H.(1,2); CHEN X.(1,2); SHEN Y.(3); LIU F.(1,2); YIN X.(1); LIU L.(1); TIMKO M.(4); QI H.(5); FAN L.(1,2,3)
    (1) Institute of Crop Science, Zhejiang University, Hangzhou, P.R. China; (2) Research Center for Air Pollution and Health, Zhejiang University, Hangzhou, P.R. China; (3) Institute of Bioinformatics, Zhejiang University, Hangzhou, P.R. China; (4) Department of Public Health Sciences, School of Medicine, University of Virginia, Charlottesville, VA, U.S.A.; (5) Department of Pathology and Pathophysiology, School of Basic Medical Sciences, Zhejiang University, Hangzhou, P.R. China
    Harm-reduced cigarettes have been greatly developed to minimize the negative impact of smoking on health. However, the practical effects of such products are still under debate. Along with the application of high-throughput sequencing technologies (such ...
  2. CORESTA Meeting, Smoke Science/Product Technology, 2019, Hamburg, STPOST 32

    Enumeration of TBNK cells: A case for a bioanalytical assay to support clinical studies for the development of modified risk tobacco products

    NEWLAND K.; MILLER P.; FARMEN R.
    Celerion, Inc., Lincoln, NE, U.S.A.
    Smoking has been reported to lessen the body’s immune response making it more susceptible to infections. Chronic cigarette smoke exposure causes imbalance in immune homeostasis affecting the circulating immune cells. Peripheral blood lymphocytes are ...
  3. CORESTA Congress, Kunming, 2018, Agronomy/Phytopathology Groups, AP 04

    Regulation network of nicotine biosynthesis in tobacco: the non-coding players

    CHEN Xi(1,2); SUN S.(1,2); SHEN E.(1,2); WANG W.(1,2); LI F.(1); LIU F.(1,2); CHEN H.(1,2); YE C.(1,2); XIAO B.(3); FAN L.(1,2)
    (1) Institute of Crop Science, Zhejiang University, Hangzhou, P.R. China; (2) Institute of Bioinformatics, Zhejiang University, Hangzhou, P.R. China; (3) Yunnan Academy of Tobacco Agricultural Sciences and China Tobacco Breeding Research Center, Yunnan, Yuxi, P.R. China
    Several key gene encoding enzymes of nicotine biosynthesis and catabolism pathways have been characterized in tobacco. Non-coding RNAs (ncRNAs) are transcripts with no or low protein coding potential. ncRNAs include microRNAs (miRNAs) with a size of 20-24 ...
  4. CORESTA Congress, Kunming, 2018, Smoke Science/Product Technology Groups, ST 01

    In vitro biological safety evaluation of cigarette smoke

    CHEN Xi(1,2); SHEN Y.(1,2); CHEN Hongyu(1,2); LIU F.(1,2); QI H.(3); JIMIN S.(3); TIMKO M.(4); FAN L.(1,2)
    (1) Research Center for Air Pollution and Health, Zhejiang University, Hangzhou, P.R. China; (2) Institute of Bioinformatics, Zhejiang University, Hangzhou, P.R. China; (3) Department of Pathology and Pathophysiology, School of Basic Medical Sciences, Zhejiang University, Hangzhou, P.R. China; (4) Department of Public Health Sciences, School of Medicine, University of Virginia, Charlottesville, VA, U.S.A.
    Traditionally, toxicological evaluation of cigarette smoke has focused on the harmful chemical content of smoke. Harm-reduced cigarettes should not only refer to these chemical compounds, but also to the degree of the effect of whole smoke on human cells. ...
  5. CORESTA Congress, Kunming, 2018, Smoke Science/Product Technology Groups, ST 17

    A clinical study investigating changes in exposure to cigarette smoke chemicals in U.K. smokers who switch to using a tobacco heating product for a five-day period

    McEWAN M.(1); EBAJEMITO J.K.(1); GALE N.(1); ELDRIDGE A.(1); CAMACHO O.M.(1); MURPHY J.(1); HARDIE G.(1); PROCTOR C.J.(1)
    (1) British American Tobacco (Investments) Limited, R&D, Southampton, U.K.; (2) Celerion Inc., Lincoln, NE, U.S.A.
    Smoking is a leading cause of numerous diseases, particularly lung cancer, chronic obstructive pulmonary disease and cardiovascular diseases. Consequently, there is a recognized need to provide smokers with alternative nicotine-delivery devices that have ...
  6. CORESTA Congress, Kunming, 2018, Smoke Science/Product Technology Groups, ST 44

    Time and spatially resolved in-situ determination of temperature, pressure and gas phase concentration of selected smoke constituents inside a burning superslim cigarette. Part I – Thermophysical mapping

    CUI Huapeng(1); EHLERT S.(2); XIE Fuwei(1); DENG Nan(1); LI Bin(1); LIU Chuan(3); McADAM K.(3); WALTE A.(2); ZIMMERMANN R.(2)
    (1) Zhengzhou Tobacco Research Institute of CNTC, Zhengzhou, Henan, P.R. China; (2) Photonion GmbH, Schwerin, Germany; (3) British American Tobacco (Investments) Limited, Global R&D, Southampton, U.K.
    Superslim cigarettes in China are a relevant product category on the market. Accurate determination of key thermo-physical and-chemical parameters in superslim cigarettes are essential for the mechanistic understanding of combustion as well as pyrolysis ...
  7. CORESTA Congress, Kunming, 2018, Smoke Science/Product Technology Groups, ST 59

    An inter-laboratory comparison study focused on the determination of total NNAL in human urine

    NEWLAND K.(1); SCHERER M.(2); HECHT S.S.(3); TROUDE V.(4); PRASAD G.L.(5)
    (1) Celerion Inc., Lincoln, NE, U.S.A.; (2) ABF GmbH, Planegg, Germany; (3) University of Minnesota Cancer Center, Minneapolis, MN, U.S.A.; (4) Reemtsma Cigarettenfabriken GmbH, Imperial Brands plc, Hamburg, Germany; (5) RAI Services Company, Winston-Salem, NC, U.S.A.
    In an ongoing effort to fulfil the second objective of the CORESTA Biomarker Sub-Group, periodic inter-laboratory comparison studies have been performed to evaluate the consistency of the quantitation for various harmful or potentially harmful exposure ...
  8. TSRC, Tob. Sci. Res. Conf., 2017, 71, abstr. 014

    Analysis of isotopically labeled glycerol to measure exposure from e-cigarettes

    DIBBERN E.M.; KAFONEK C.J.; BROWN G.P.; DZERK A.M.; NACHI R.; NEWLAND K.E.; ISLAM R. (presented by Erika Pfaumiller)
    Celerion, Lincoln, NE, USA
    Electronic cigarettes (ecigs) have become a popular mode of nicotine ingestion. They are often promoted as being less harmful than traditional cigarettes, but research supporting that claim is incomplete. The main chemical components of ecigs are ...
  9. TSRC, Tob. Sci. Res. Conf., 2017, 71, abstr. 067

    Development of an analytical method to detect methyl salicylate in human plasma

    MILLER S.(1); NEWLAND K.(2); LIU J.(1); SARKAR M.(1)
    (1) Altria Client Services, Richmond, VA, USA; (2) Celerion, Lincoln, NE, USA
    Wintergreen is used as a common flavor in many moist smokeless tobacco (MST) products and is also widely used as a food flavorant as well as an over-the-counter analgesic to relieve muscle aches. MST products, including wintergreen flavored products, have ...