1. CORESTA Meeting, Smoke Science/Product Technology, 2019, Hamburg, ST 53

    NNN – a suitable biomarker of exposure from smoke and new nicotine delivery products?

    PLUYM N.; TAUCHER J.; SCHERER G.; SCHERER M.
    ABF Analytisch-Biologisches Forschungslabor GmbH, Planegg, Germany
    N-Nitrosonornicotine (NNN) is believed to play a critical role in the development of cancer in tobacco users and was therefore classified by the International Agency for Research on Cancer (IARC) as a Group 1 carcinogen. Hence, urinary NNN is commonly ...
  2. CORESTA Meeting, Smoke Science/Product Technology, 2019, Hamburg, ST 54

    Clinical biomarkers of compliance for use in potentially reduced-risk product switching studies

    McEWAN M.(1); GALE N.(1); HARDIE G.(1); SCHERER M.(2); PLUYM N.(2); EBAJEMITO J.K.(1); CAMACHO O.M.(1); GRIFFITHS A.(1); PROCTOR C.J.(1)
    (1) British American Tobacco (Investments) Limited, Research and Development, Southampton, U.K.; (2) ABF GmbH, Planegg, Germany
    Preclinical assessments and clinical studies have shown significant reductions in toxicants in tobacco heating product (THP) aerosols compared to smoke from conventional cigarettes. Further studies to assess if these toxicant reductions translate to ...
  3. CORESTA Meeting, Smoke Science/Product Technology, 2019, Hamburg, STPOST 13

    Analysis of propylene oxide and glycidol in tobacco smoke and e-cigarette vapour

    LANDMESSER A.; SCHERER G.; PLUYM N.; SCHERER M.
    ABF Analytisch-Biologisches Forschungslabor GmbH, Planegg, Germany
    We recently performed a clinical study with e-cigarette users (vapers) and smokers. The stable-isotope labeled e-cigarette constituents propylene glycol, glycerol, and nicotine in the test e-cigarette were used in order to investigate the e-cigarette ...
  4. CORESTA Meeting, Smoke Science/Product Technology, 2019, Hamburg, STPOST 32

    Enumeration of TBNK cells: A case for a bioanalytical assay to support clinical studies for the development of modified risk tobacco products

    NEWLAND K.; MILLER P.; FARMEN R.
    Celerion, Inc., Lincoln, NE, U.S.A.
    Smoking has been reported to lessen the body’s immune response making it more susceptible to infections. Chronic cigarette smoke exposure causes imbalance in immune homeostasis affecting the circulating immune cells. Peripheral blood lymphocytes are ...
  5. CORESTA Congress, Kunming, 2018, Smoke Science/Product Technology Groups (Workshop), STW 07

    Identifying suitable biomarkers of biological effects (BOBEs) for evaluating reduced risk products

    SCHERER G.; PLUYM N.; SCHERER M.
    ABF Analytisch-Biologisches Forschungslabor GmbH, Planegg, Germany
    Switching from conventional cigarettes (CCs) to reduced risk products (RRPs), such as e cigarettes, heat-not-burn and oral tobacco products, could be an effective approach for tobacco harm reduction (THR), provided that the use of RRPs effectively entails ...
  6. CORESTA Congress, Kunming, 2018, Smoke Science/Product Technology Groups, ST 17

    A clinical study investigating changes in exposure to cigarette smoke chemicals in U.K. smokers who switch to using a tobacco heating product for a five-day period

    McEWAN M.(1); EBAJEMITO J.K.(1); GALE N.(1); ELDRIDGE A.(1); CAMACHO O.M.(1); MURPHY J.(1); HARDIE G.(1); PROCTOR C.J.(1)
    (1) British American Tobacco (Investments) Limited, R&D, Southampton, U.K.; (2) Celerion Inc., Lincoln, NE, U.S.A.
    Smoking is a leading cause of numerous diseases, particularly lung cancer, chronic obstructive pulmonary disease and cardiovascular diseases. Consequently, there is a recognized need to provide smokers with alternative nicotine-delivery devices that have ...
  7. CORESTA Congress, Kunming, 2018, Smoke Science/Product Technology Groups, ST 44

    Time and spatially resolved in-situ determination of temperature, pressure and gas phase concentration of selected smoke constituents inside a burning superslim cigarette. Part I – Thermophysical mapping

    CUI Huapeng(1); EHLERT S.(2); XIE Fuwei(1); DENG Nan(1); LI Bin(1); LIU Chuan(3); McADAM K.(3); WALTE A.(2); ZIMMERMANN R.(2)
    (1) Zhengzhou Tobacco Research Institute of CNTC, Zhengzhou, Henan, P.R. China; (2) Photonion GmbH, Schwerin, Germany; (3) British American Tobacco (Investments) Limited, Global R&D, Southampton, U.K.
    Superslim cigarettes in China are a relevant product category on the market. Accurate determination of key thermo-physical and-chemical parameters in superslim cigarettes are essential for the mechanistic understanding of combustion as well as pyrolysis ...
  8. CORESTA Congress, Kunming, 2018, Smoke Science/Product Technology Groups, ST 59

    An inter-laboratory comparison study focused on the determination of total NNAL in human urine

    NEWLAND K.(1); SCHERER M.(2); HECHT S.S.(3); TROUDE V.(4); PRASAD G.L.(5)
    (1) Celerion Inc., Lincoln, NE, U.S.A.; (2) ABF GmbH, Planegg, Germany; (3) University of Minnesota Cancer Center, Minneapolis, MN, U.S.A.; (4) Reemtsma Cigarettenfabriken GmbH, Imperial Brands plc, Hamburg, Germany; (5) RAI Services Company, Winston-Salem, NC, U.S.A.
    In an ongoing effort to fulfil the second objective of the CORESTA Biomarker Sub-Group, periodic inter-laboratory comparison studies have been performed to evaluate the consistency of the quantitation for various harmful or potentially harmful exposure ...
  9. CORESTA Congress, Kunming, 2018, Smoke Science/Product Technology Groups, ST 61

    Novel biomarkers to characterize exposure to aldehydes from e-vapor products based on stable-isotope constituents

    LANDMESSER A.(1); SCHERER M.(1); SCHERER G.(1); SARKAR M.(2); EDMISTON J.S.(2); PLUYM N.(1)
    (1) ABF Analytisch-Biologisches Forschungslabor GmbH, Planegg, Germany; (2) Altria Client Services LLC, Center for Research and Technology, Richmond, VA, U.S.A.
    E vapor products (EVP) are an emerging category of non-combustible tobacco products that hold the promise of harm reduction for users of combustible products. Degradation products such as aldehydes have received much attention lately, however human ...
  10. CORESTA Congress, Kunming, 2018, Smoke Science/Product Technology Groups, STPOST 40

    Analytical methods for the determination of aldehydes in e-vapor aerosol and cigarette smoke and their urinary biomarkers of exposure

    LANDMESSER A.(1); SCHERER M.(1); SCHERER G.(1); SARKAR M.(2); EDMISTON J.S.(2); PLUYM N.(1)
    (1) ABF Analytisch-Biologisches Forschungslabor GmbH, Planegg, Germany; (2) Altria Client Services, Center for Research and Technology, Richmond, VA, U.S.A.
    Potential exposure to aldehydes, such as acrolein, formaldehyde or acetaldehyde, formed due to thermal degradation of the e-liquid constituents propylene glycol (PG) and glycerol (G) during the consumption of e-vapor products (EVPs), have received much ...