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122 results

  1. CORESTA Meeting, Smoke Science/Product Technology, 2019, Hamburg, STPOST 32

    Enumeration of TBNK cells: A case for a bioanalytical assay to support clinical studies for the development of modified risk tobacco products

    NEWLAND K.; MILLER P.; FARMEN R.
    Celerion, Inc., Lincoln, NE, U.S.A.
    Smoking has been reported to lessen the body’s immune response making it more susceptible to infections. Chronic cigarette smoke exposure causes imbalance in immune homeostasis affecting the circulating immune cells. Peripheral blood lymphocytes are ...
  2. TSRC, Tob. Sci. Res. Conf., 2019, 73, abstr. 091

    Tobacco-specific nitrosamines in the mainstream smoke of commercial little cigars

    EDWARDS S.H.(1); HASSINK M.(1); TAYLOR K.M.(1); WATSON C.(2); KUKLENYIK P.(2); WANG R.(2); CHEN P.(2); VALENTIN-BLASINI L.(2); KIMBRELL B.(2)
    (1) US Food and Drug Administration (FDA), Silver Spring, MD, USA; (2) Centers for Disease Control and Prevention, Atlanta, GA, USA
    Cigars are among the broad variety of deemed tobacco products that have been less extensively studied and characterized than cigarettes. Small sheet-wrapped cigars, often called little cigars, are a subcategory of cigars that are similar to conventional ...
  3. CORESTA Congress, Kunming, 2018, Smoke Science/Product Technology Groups (Workshop), STW 06

    Biomarkers of tobacco smoke exposure in the U.S. population: result and resources from the National Health and Nutrition Examination Survey (NHANES)

    BLOUNT B.C.
    Tobacco and Volatiles Branch, Division of Laboratory Sciences, Centers for Disease Control and Prevention, Atlanta, GA, U.S.A.
    Tobacco smoke exposure is the primary cause of disease and premature death in the U.S. population and a major contributor to negative health impact globally. Tobacco smoke harms the health of active users and non-users with indirect exposure. Biomarkers ...
  4. CORESTA Congress, Kunming, 2018, Smoke Science/Product Technology Groups, ST 17

    A clinical study investigating changes in exposure to cigarette smoke chemicals in U.K. smokers who switch to using a tobacco heating product for a five-day period

    McEWAN M.(1); EBAJEMITO J.K.(1); GALE N.(1); ELDRIDGE A.(1); CAMACHO O.M.(1); MURPHY J.(1); HARDIE G.(1); PROCTOR C.J.(1)
    (1) British American Tobacco (Investments) Limited, R&D, Southampton, U.K.; (2) Celerion Inc., Lincoln, NE, U.S.A.
    Smoking is a leading cause of numerous diseases, particularly lung cancer, chronic obstructive pulmonary disease and cardiovascular diseases. Consequently, there is a recognized need to provide smokers with alternative nicotine-delivery devices that have ...
  5. CORESTA Congress, Kunming, 2018, Smoke Science/Product Technology Groups, ST 44

    Time and spatially resolved in-situ determination of temperature, pressure and gas phase concentration of selected smoke constituents inside a burning superslim cigarette. Part I – Thermophysical mapping

    CUI Huapeng(1); EHLERT S.(2); XIE Fuwei(1); DENG Nan(1); LI Bin(1); LIU Chuan(3); McADAM K.(3); WALTE A.(2); ZIMMERMANN R.(2)
    (1) Zhengzhou Tobacco Research Institute of CNTC, Zhengzhou, Henan, P.R. China; (2) Photonion GmbH, Schwerin, Germany; (3) British American Tobacco (Investments) Limited, Global R&D, Southampton, U.K.
    Superslim cigarettes in China are a relevant product category on the market. Accurate determination of key thermo-physical and-chemical parameters in superslim cigarettes are essential for the mechanistic understanding of combustion as well as pyrolysis ...
  6. CORESTA Congress, Kunming, 2018, Smoke Science/Product Technology Groups, ST 59

    An inter-laboratory comparison study focused on the determination of total NNAL in human urine

    NEWLAND K.(1); SCHERER M.(2); HECHT S.S.(3); TROUDE V.(4); PRASAD G.L.(5)
    (1) Celerion Inc., Lincoln, NE, U.S.A.; (2) ABF GmbH, Planegg, Germany; (3) University of Minnesota Cancer Center, Minneapolis, MN, U.S.A.; (4) Reemtsma Cigarettenfabriken GmbH, Imperial Brands plc, Hamburg, Germany; (5) RAI Services Company, Winston-Salem, NC, U.S.A.
    In an ongoing effort to fulfil the second objective of the CORESTA Biomarker Sub-Group, periodic inter-laboratory comparison studies have been performed to evaluate the consistency of the quantitation for various harmful or potentially harmful exposure ...
  7. TSRC, Tob. Sci. Res. Conf., 2018, 72, abstr. 046

    The quantitation of volatile nitrosamines in mainstream tobacco smoke by gas chromatography-tandem mass spectrometry (GC-MS/MS) using direct sample bag collection

    COWAN E.A.; WINKELJOHN W.R.; LISKO J.G.; VALENTIN-BLASINI L.
    Centers for Disease Control and Prevention, Atlanta, GA, USA
    Volatile nitrosamines (VNAs) are classified as group 2A and 2B carcinogens in humans by the International Agency for Research on Cancer (IARC), have been associated with increased incidences of carcinogenesis and have been linked to lipid peroxidation, ...
  8. TSRC, Tob. Sci. Res. Conf., 2018, 72, abstr. 048

    Survey of nicotine, NNK, NNN, pH and physical properties of little cigars in the US market place

    LIU Youbang(1); HASSINK M.D.(1); TAYLOR K.M.(1); WATSON C.(2); CHAFIN D.(2); LAWLER T.(2); VALENTIN-BLASINI L.(2); KIMBRALL B.(2)
    (1) U.S. Food and Drug Administration, Silver Spring, MD, USA; (2) Centers for Disease Control and Prevention, Atlanta, GA, USA
    In May 2016, the jurisdiction of the Federal Food Drug and Cosmetic Act was extended to include all tobacco products, including cigars. Because limited information exists on the chemistry of cigar filler and smoke, 60 brands of popular little cigars sold ...
  9. TSRC, Tob. Sci. Res. Conf., 2017, 71, abstr. 014

    Analysis of isotopically labeled glycerol to measure exposure from e-cigarettes

    DIBBERN E.M.; KAFONEK C.J.; BROWN G.P.; DZERK A.M.; NACHI R.; NEWLAND K.E.; ISLAM R. (presented by Erika Pfaumiller)
    Celerion, Lincoln, NE, USA
    Electronic cigarettes (ecigs) have become a popular mode of nicotine ingestion. They are often promoted as being less harmful than traditional cigarettes, but research supporting that claim is incomplete. The main chemical components of ecigs are ...