Search Results

112 results

  1. CORESTA Congress, Kunming, 2018, Smoke Science/Product Technology Groups, ST 17

    A clinical study investigating changes in exposure to cigarette smoke chemicals in U.K. smokers who switch to using a tobacco heating product for a five-day period

    McEWAN M.(1); EBAJEMITO J.K.(1); GALE N.(1); ELDRIDGE A.(1); CAMACHO O.M.(1); MURPHY J.(1); HARDIE G.(1); PROCTOR C.J.(1)
    (1) British American Tobacco (Investments) Limited, R&D, Southampton, U.K.; (2) Celerion Inc., Lincoln, NE, U.S.A.
    Smoking is a leading cause of numerous diseases, particularly lung cancer, chronic obstructive pulmonary disease and cardiovascular diseases. Consequently, there is a recognized need to provide smokers with alternative nicotine-delivery devices that have ...
  2. CORESTA Congress, Kunming, 2018, Smoke Science/Product Technology Groups, ST 44

    Time and spatially resolved in-situ determination of temperature, pressure and gas phase concentration of selected smoke constituents inside a burning superslim cigarette. Part I – Thermophysical mapping

    CUI Huapeng(1); EHLERT S.(2); XIE Fuwei(1); DENG Nan(1); LI Bin(1); LIU Chuan(3); McADAM K.(3); WALTE A.(2); ZIMMERMANN R.(2)
    (1) Zhengzhou Tobacco Research Institute of CNTC, Zhengzhou, Henan, P.R. China; (2) Photonion GmbH, Schwerin, Germany; (3) British American Tobacco (Investments) Limited, Global R&D, Southampton, U.K.
    Superslim cigarettes in China are a relevant product category on the market. Accurate determination of key thermo-physical and-chemical parameters in superslim cigarettes are essential for the mechanistic understanding of combustion as well as pyrolysis ...
  3. CORESTA Congress, Kunming, 2018, Smoke Science/Product Technology Groups, ST 59

    An inter-laboratory comparison study focused on the determination of total NNAL in human urine

    NEWLAND K.(1); SCHERER M.(2); HECHT S.S.(3); TROUDE V.(4); PRASAD G.L.(5)
    (1) Celerion Inc., Lincoln, NE, U.S.A.; (2) ABF GmbH, Planegg, Germany; (3) University of Minnesota Cancer Center, Minneapolis, MN, U.S.A.; (4) Reemtsma Cigarettenfabriken GmbH, Imperial Brands plc, Hamburg, Germany; (5) RAI Services Company, Winston-Salem, NC, U.S.A.
    In an ongoing effort to fulfil the second objective of the CORESTA Biomarker Sub-Group, periodic inter-laboratory comparison studies have been performed to evaluate the consistency of the quantitation for various harmful or potentially harmful exposure ...
  4. CORESTA Meeting, Smoke Science/Product Technology, 2017, Kitzbühel, STPOST 40 (also presented at TSRC 2017)

    A comparison of two different extraction methods for aromatic amines in mainstream smoke using gas chromatography-tandem mass spectrometry (GC/QQQ)

    STINSON A.(1); GILLILAND S.(1); HUCKINS A.(1); GILLMAN I.G.(2); BROWN S.S.(2); STEELMAN D.(1)
    (1) Liggett Group LLC, Mebane, NC, U.S.A.; (2) Enthalpy Analytical Inc., Durham, NC, U.S.A.
    The established GC-MS methods for the analysis of aromatic amines (o-Anisidine, o-Toluidine, 2,6-Dimethylaniline, 1-Aminonaphthalene, 2-Aminonaphthalene, and 4-Aminobiphenyl) involve complex sample preparation and analyzing the samples on a gas ...
  5. TSRC, Tob. Sci. Res. Conf., 2017, 71, abstr. 014

    Analysis of isotopically labeled glycerol to measure exposure from e-cigarettes

    DIBBERN E.M.; KAFONEK C.J.; BROWN G.P.; DZERK A.M.; NACHI R.; NEWLAND K.E.; ISLAM R. (presented by Erika Pfaumiller)
    Celerion, Lincoln, NE, USA
    Electronic cigarettes (ecigs) have become a popular mode of nicotine ingestion. They are often promoted as being less harmful than traditional cigarettes, but research supporting that claim is incomplete. The main chemical components of ecigs are ...
  6. TSRC, Tob. Sci. Res. Conf., 2017, 71, abstr. 048 (also presented at CORESTA SSPT2017)

    A comparison of two different extraction methods for aromatic amines in mainstream smoke using gas chromatography-tandem mass spectrometry (GC/QQQ)

    STINSON A.(1); GILLILAND S.(1); HUCKINS A.(1); BROWN S.S.(2); GILLMAN I.G.(2)
    (1) Liggett Group, Mebane, NC, USA; (2) Enthalpy Analytical, Durham, NC, USA
    The established GC-MS methods for the analysis of aromatic amines (o Anisidine, o Toluidine, 2, 6 Dimethylaniline, 1 Aminonaphthalene, 2 Aminonaphthalene, and 4 Aminobiphenyl) involve complex sample preparation and analyzing the samples on a gas ...
  7. TSRC, Tob. Sci. Res. Conf., 2017, 71, abstr. 067

    Development of an analytical method to detect methyl salicylate in human plasma

    MILLER S.(1); NEWLAND K.(2); LIU J.(1); SARKAR M.(1)
    (1) Altria Client Services, Richmond, VA, USA; (2) Celerion, Lincoln, NE, USA
    Wintergreen is used as a common flavor in many moist smokeless tobacco (MST) products and is also widely used as a food flavorant as well as an over-the-counter analgesic to relieve muscle aches. MST products, including wintergreen flavored products, have ...
  8. CORESTA Congress, Berlin, 2016, Smoke Science/Product Technology Groups, ST 04

    Reduction of harmful or potentially harmful constituents (HPHCs) following partial or complete substitution of cigarettes with electronic cigarettes in adult smokers

    D’RUIZ C.D.(1); O’CONNELL G.(2); GRAFF D.W.(3)
    (1) Scientific Affairs Consultant, Fontem Ventures, B.V., Greensboro, NC, U.S.A.; (2) Fontem Ventures, B.V., Scientific and Regulatory Affairs, Amsterdam, The Netherlands; (3) Celerion, Lincoln, NE, U.S.A.
    Changes in fifteen urine, blood, and exhaled breath biomarkers of exposure (BoE) to harmful and potentially harmful constituents (HPHCs), representing major classes of compounds reported by the FDA to be significant contributors to smoking-associated ...
  9. CORESTA Congress, Berlin, 2016, Smoke Science/Product Technology Groups, ST 06

    Evaluation of a biomarker of oxidative stress: 8-iso-prostaglandin F2α / prostaglandin F2α ratio

    NEWLAND K.(1); MILLER P.(1); FARMEN R.(1); TRAN C.T.(2); HAZIZA C.(2); PICAVET P.(2)
    (1) Celerion, Inc., Lincoln, NE, U.S.A.; (2) Philip Morris Products S.A. (part of Philip Morris International group of companies), Neuchâtel, Switzerland
    It is understood that exposure to free radicals related to tobacco use negatively impacts smoker health. Studies have been performed measuring fatty acid oxidation products (F2-Isoprostanes) in human urine as biomarkers of harm from free radical exposure. ...