1. CORESTA Congress, Berlin, 2016, Smoke Science/Product Technology Groups, ST 04

    Reduction of harmful or potentially harmful constituents (HPHCs) following partial or complete substitution of cigarettes with electronic cigarettes in adult smokers

    D’RUIZ C.D.(1); O’CONNELL G.(2); GRAFF D.W.(3)
    (1) Scientific Affairs Consultant, Fontem Ventures, B.V., Greensboro, NC, U.S.A.; (2) Fontem Ventures, B.V., Scientific and Regulatory Affairs, Amsterdam, The Netherlands; (3) Celerion, Lincoln, NE, U.S.A.
    Changes in fifteen urine, blood, and exhaled breath biomarkers of exposure (BoE) to harmful and potentially harmful constituents (HPHCs), representing major classes of compounds reported by the FDA to be significant contributors to smoking-associated ...
  2. CORESTA Congress, Berlin, 2016, Smoke Science/Product Technology Groups, ST 06

    Evaluation of a biomarker of oxidative stress: 8-iso-prostaglandin F2α / prostaglandin F2α ratio

    NEWLAND K.(1); MILLER P.(1); FARMEN R.(1); TRAN C.T.(2); HAZIZA C.(2); PICAVET P.(2)
    (1) Celerion, Inc., Lincoln, NE, U.S.A.; (2) Philip Morris Products S.A. (part of Philip Morris International group of companies), Neuchâtel, Switzerland
    It is understood that exposure to free radicals related to tobacco use negatively impacts smoker health. Studies have been performed measuring fatty acid oxidation products (F2-Isoprostanes) in human urine as biomarkers of harm from free radical exposure. ...
  3. CORESTA Congress, Berlin, 2016, Smoke Science/Product Technology Groups, ST 23

    Pharmacokinetics of nicotine following single controlled use of a new type of tobacco: heated tobacco product

    GILES L.(1); YUKI D.(2); SHERWOOD N.(3); GRAFF D.W.(4); NEWLAND K.(4)
    (1) JT International SA, Ballymena, Co. Antrim, U.K.; (2) Japan Tobacco Inc., Yokohama, Kanagawa, Japan; (3) Neil Sherwood Consulting, Commugny, Switzerland; (4) Celerion, Lincoln, NE, U.S.A.
    Nicotine is one of the most characteristic compounds contained in any type of tobacco product including cigarettes. Previous studies have reported that different types of tobacco products display differences in nicotine pharmacokinetics. NHTP is a new ...
  4. TSRC, Tob. Sci. Res. Conf., 2016, 70, abstr. 20

    Evaluation of a biomarker of oxidative stress: the 8-iso prostaglandin F2α: prostaglandin F2α ratio in human plasma

    MILLER P.(1); NEWLAND K.(1); DZERK A.(1); FARMEN R.(1); TRAN C.T.(2); HAZIZA C.(2); PICAVET P.(2)
    (1) Celerion, Inc., Lincoln, NE, USA; (2) Philip Morris International, Neuchâtel, Switzerland
    F2-isoprostanes have been widely studied as biomarkers of oxidative stress for various indications, including smoking. Since both enzymatic biosynthesis and chemical lipid peroxidation can generate these biomarkers, there are various interpretations that ...
  5. TSRC, Tob. Sci. Res. Conf., 2016, 70, abstr. 23

    Reductions in biomarkers of exposure (BoE) to harmful or potentially harmful constituents (HPHCs) following partial or complete substitution of cigarettes with electronic cigarettes in adult smokers

    O’CONNELL G.(1); GRAFF D.W.(2); D’RUIZ C.(3)
    (1) Fontem Ventures B.V, Amsterdam, The Netherlands; (2) Celerion Inc, Lincoln, NE, USA; (3) Fontem Ventures B.V Greensboro, NC, USA
    Changes in fifteen urine, blood and exhaled breath BoEs of HPHCs representing classes of compounds reported by FDA to be significant contributors to smoking-associated disease risks were measured in 105 clinical-confined subjects following randomization ...