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76 results

  1. TSRC, Tob. Sci. Res. Conf., 2017, 71, abstr. 057

    AKR1C1 as a biomarker for differentiating the biological effects of combustible from non-combustible tobacco products

    TRAN Q.T.(1); WOO S.(2); HENDERSON D.(2); GAO H.(3); ZACHARIAS W.(3); LIU G.(1); PRASAD G.L.(1)
    (1) RAI Services Company, Winston-Salem, NC, USA; (2) Axio Research, Seattle, WA, USA; (3) University of Louisville School of Medicine, Louisville, KY, USA
    Smoking has been established as a major risk factor for developing oral squamous cell carcinoma (OSCC), but less attention has been paid to the effects of smokeless tobacco products. Our objective is to identify potential biomarkers to distinguish the ...
  2. TSRC, Tob. Sci. Res. Conf., 2013, 67, abstr. 07

    Benzo[a]pyrene in tobacco products by ultra-pressure liquid chromatography with fluorescence detection using its deuterated analog as an internal standard.

    SODEN C.; WILLIAMSON F.
    Arista Laboratories, Inc., Richmond, VA, USA
    Benzo[a]pyrene (BaP) is a polycyclic aromatic hydrocarbon (PAH) classified by the International Agency for Research on Cancer (IARC) as a group 1 carcinogen. BaP is formed as a product of incomplete combustion and is found in tobacco smoke as well as ...
  3. CORESTA Congress, Sapporo, 2012, Smoke Science/Product Technology Groups, SSPTPOST 06

    Combusted, but not smokeless tobacco product preparations, cause DNA damage in human oral cavity cells

    ZACHARIAS W.(1); GAO H.(1); PRASAD G.L.(2)
    (1) Dept. of Medicine, J.G. Brown Cancer Center, University of Louisville, Louisville, KY, USA; (2) R.J. Reynolds Tobacco Co., R&D Department, Winston-Salem, NC, USA
    We examined the effects of reference tobacco preparations on DNA damage in human oral cavity cells. The oral squamous cell carcinoma cell line (101A), normal human gingival epithelial cells (HGEC), and human gingival fibroblasts (HGF) were treated with ...