Search Results

187 results

  1. CORESTA Meeting, Agronomy/Phytopathology, 2019, Victoria Falls, AP 38

    Metabolic profiling of mutant tobaccos with distinctive aroma based on gas chromatography-mass spectrometry and multivariate analysis

    CAO Jianmin; XU Xiaoling; LIU Guanshan; CAO Pengyun; LIN Yingnan
    Tobacco Research Institute of Chinese Academy of Agricultural Sciences, Qingdao, P.R. China; Graduate School of CAAS, Beijing 100081, P.R. China
    A large number of mutant materials were obtained by chemical mutagenesis of tobacco with ethyl methylsulfonate (EMS) and new materials with distinctive aroma characteristics were achieved by field screening, identification and sensory evaluation. To...
  2. CORESTA Meeting, Agronomy/Phytopathology, 2019, Victoria Falls, APPOST 08

    Characterisation and genetic mapping of a novel premature leaf senescence mutant yellow leaf 1 in common tobacco (Nicotiana tabacum L.)

    GAO Xiaoming; WU Xinru; SUN Yuhe; LIU Guanshan; ZHANG Zengling; CHAO Jiangtao; LI Zhiyuan; GUO Yongfeng
    Tobacco Research Institute, Chinese Academy of Agricultural Sciences, Qingdao, P.R. China
    Ripe (yellowing) leaves are harvested and cured in tobacco farming. Leaf senescence therefore has a great impact on yield and quality of tobacco. However, little is known about the molecular mechanism of tobacco leaf senescence regulation. The...
  3. CORESTA Meeting, Agronomy/Phytopathology, 2019, Victoria Falls, APPOST 16

    Effects of biochar and seaweed fertiliser on tobacco growth, soil properties and bacterial wilt occurrence

    ZHANG Guangyu(1); YOU Xiangwei(1); LIU Yuande(2); CHU Depeng(1); NIU Jijun(2); GAO Qiang(2); CHEN Qianru(1); LI Yiqiang(1); WEI Jianyu(3)
    (1) Tobacco Research Institute of CAAS, Qingdao, P.R. China; (2) Shandong Linyi Tobacco Company Ltd., Linyi, Shandong, P.R. China; (3) China Tobacco Guangxi Industrial Co., Ltd., Nanning, P.R. China
    Bacterial wilt of tobacco incited by Ralstonia solanacearum is prevalent worldwide and causes severe economic losses every year. Up until now there is no promising control method available against the disease. This study aimed to elucidate the effect...
  4. CORESTA Meeting, Smoke Science/Product Technology, 2019, Hamburg, ST 44

    Lung biomarkers of harm/effect for tobacco regulatory research: opportunities and challenges – a literature review

    MAKENA P.(1); EDMISTON J.(2); BEATTIE E.(3); MASON E.(4); McEWAN M.(5); PRASAD K.(5)
    (1) RAI Services Company, Winston-Salem, NC, U.S.A.; (2) Altria Client Services LLC, Richmond, VA, U.S.A.; (3) Cliantha Research Limited, Canada; (4) Imperial Brands PLC, Bristol, U.K.; (5) British American Tobacco (Investments) Limited, Southampton, U.K.
    Biomarkers of potential harm (BoPH) are indicators of biological perturbations in response to smoking, which may contribute to smoking-related disease. In this review, a project of the CORESTA Biomarkers Sub-Group, we critically assessed the...
  5. CORESTA Meeting, Smoke Science/Product Technology, 2019, Hamburg, ST 45

    Meta-analysis of two biomarkers of exposure of tobacco products

    AYALA-FIERRO F.(1); ELAMIN A.(2); FROST-PINEDA K.(3); JIN T.(3); PRASAD G.L.(3); SARKAR M.(4); SCHMIDT E.(3); VERRON T.(5)
    (1) ITG Brands LLC, Greensboro, NC, U.S.A.; (2) PMI R&D, Philip Morris Products S.A., Neuchâtel, Switzerland; (3) RAI Services Company, Winston-Salem, NC, U.S.A.; (4) Altria Client Services LLC, Richmond, VA, U.S.A.; (5) SEITA - Imperial Brands, Paris, France
    In the context of tobacco products, broadly two types of biomarkers exist, biomarkers of exposure (BoE) and biomarkers of potential harm (BoPH). BoE measure exposure to tobacco constituents, e.g. carbon monoxide (CO) and nicotine equivalents (NEQs)....
  6. CORESTA Meeting, Smoke Science/Product Technology, 2019, Hamburg, STPOST 42

    Characterization of whole mainstream smoke/aerosol delivery within the Vitrocell® Ames 48 high throughput exposure module using different tobacco product types

    LEVERETTE R.(1); KEYSER B.(1); SEYMOUR A.(2); HOLLINGS M.(2)
    (1) RAI Services Company, Scientific & Regulatory Affairs, Winston-Salem, NC, U.S.A.; (2) Covance Laboratories Ltd, Otley Road, Harrogate, North Yorkshire, U.K.
    The preferred means of assessing combustible or other aerosol-generating tobacco products in vitro is by direct exposure of cell cultures to freshly generated whole mainstream smoke/aerosols. This approach eliminates the fractionation of...
  7. CORESTA Meeting, Smoke Science/Product Technology, 2019, Hamburg, STPOST 49

    The CORESTA in vitro test battery for combustible tobacco products: update from the 2004 Rationale and Strategy Report

    LEE K.M.(1); JORDAN K.G.(2); WIECZOREK R.(3); MOENNIKES O.(4); CLEMENTS J.(5); CROOKS I.(6); HASHIZUME T.(7); MILLER J.(8); WEBER E.(9); YOSHINO K.(7)
    (1) Altria Client Services, Richmond, VA, U.S.A.; (2) RAI Services Company, Winston-Salem, NC, U.S.A.; (3) Imperial Brands, Reemtsma Cigarettenfabriken GmbH, Hamburg, Germany; (4) PMI R&D, Philip Morris Products S.A., Neuchâtel, Switzerland; (5) Covance Laboratories Ltd, Harrogate, U.K.; (6) British American Tobacco (Investments) Ltd, R&D, Southampton, U.K.; (7) Japan Tobacco Inc., Yokohama, Kanagawa, Japan; (8) JT International SA, Geneva, Switzerland; (9) Ökolab, Vienna, Austria
    In 2004, the CORESTA In Vitro Toxicity Task Force issued a rationale and strategy report, commonly known as “the CORESTA in vitro test battery guideline”. The goals of this guideline were to: 1) develop the rationale and strategy for conducting in...
  8. CORESTA Meeting, Smoke Science/Product Technology, 2019, Hamburg, STPOST 50 (also presented at TSRC 2019)

    Altered lung barrier function is a physiologically-relevant biomarker of potential harm

    MAKENA P.; BAXTER-WRIGHT S.; CHEN P.; PRASAD G.L.
    RAI Services Company, Winston Salem, NC, U.S.A.
    Cigarette smoking is a major risk factor for diseases including cardiovascular disease, lung cancer, and chronic obstructive pulmonary disease (COPD). One of the key functions of lung epithelial cells is to serve as a physical barrier against insults...
  9. CORESTA Meeting, Smoke Science/Product Technology, 2019, Hamburg, STPOST 51

    Structural investigation of the tobacco specific urinary biomarker iPX

    SCHMIDT E.; PRASAD G.L.
    RAI Services Company, Scientific & Regulatory Affairs, Winston-Salem, NC, U.S.A.
    Biomarkers of potential harm (BoPH) are tools to assess biological and pathophysiological effects associated with chronic tobacco product use, such as oxidative stress. Isoprostanes are widely recognized as BoPH for assessing endogenous oxidative...
  10. CORESTA Meeting, Smoke Science/Product Technology, 2019, Hamburg, STPOST 52 (also presented at TSRC 2019)

    A blood-based smoking-related gene expression signature using a machine learning approach

    LIU G.; PRASAD G.L.
    RAI Services Company, Winston-Salem, NC, U.S.A.
    Smoking is a leading risk factor in the onset of multiple forms of cancer, chronic obstructive pulmonary disease, and cardiovascular disease. At present, there is a limited understanding by which changes in gene expression profiles in blood or other...