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74 results

  1. TSRC, Tob. Sci. Res. Conf., 2018, 72, abstr. 049

    Assessment of in vitro toxicity/genotoxicity of ends and combustible products

    JORDAN K.(1); BOMBICK B.(1); COOPER B.(1); LEVERETTE R.(1); SHUTSKY T.(1); WEST C.(1); STRASSER J.(1); ROUND E.(1); MARANO K.M.(1); MOMIN R.(2); TRIVEDI A.(2); WAGSTAFF W.(2); BRUCE S.(3); DAKOULAS E.(3); ROY S.(3)
    (1) RAI Services Company, Winston-Salem, NC, USA; (2) Labstat International ULC, Kitchener, ON, Canada; (3) BioReliance Corp, Rockville, MD, USA
    In May 2016, the U.S. Food and Drug Administration Center for Tobacco Products (CTP) issued draft guidance for Premarket Tobacco Product Applications (PMTA) for Electronic Nicotine Delivery Systems (ENDS), which recommends inclusion of in vitro...
  2. CORESTA Congress, Berlin, 2016, Smoke Science/Product Technology Groups, STPOST 32

    Cellular transformation activity of different tobacco condensates in the Bhas 42 cell assay

    STEVENSON M.(1); WIECZOREK R.(2); SIMMS L.(1); PANT K.(3)
    (1) Imperial Tobacco Limited, Bristol, U.K.; (2) Reemtsma Cigarettenfabriken GmbH (an Imperial Brands PLC Company), Hamburg, Germany; (3) BioReliance, Sigma-Aldrich Corp., Rockville, MD, U.S.A.
    Carcinogenesis has been described as a multi-stage process comprising of initiation, promotion and progression. Smoking is a cause of serious disease in smokers, including lung cancer. Determining the carcinogenic potential of a tobacco product...
  3. CORESTA Congress, Berlin, 2016, Smoke Science/Product Technology Groups, STPOST 35

    Comparison of the carcinogenic potential of tobacco smoke and electronic-cigarette aerosol using the Bhas cell transformation assay

    BREHENY D.(1); OKE O.(1); PANT K.(2); BRUCE S.W.(2); LAFORCE M.K.(2); CELESTIN N.(2); GAÇA M.D.(1)
    (1) British American Tobacco, R&D Centre, Southampton, U.K.; (2) BioReliance, Sigma-Aldrich Corp., Rockville, MD, U.S.A.
    In vitro cell transformation assays (CTA) are used to assess the carcinogenic potential of chemicals and complex mixtures. They can detect non-genotoxic as well as genotoxic carcinogens. The Bhas 42 CTA has been developed with both initiation and...
  4. TSRC, Tob. Sci. Res. Conf., 2013, 67, abstr. 07

    Benzo[a]pyrene in tobacco products by ultra-pressure liquid chromatography with fluorescence detection using its deuterated analog as an internal standard.

    SODEN C.; WILLIAMSON F.
    Arista Laboratories, Inc., Richmond, VA, USA
    Benzo[a]pyrene (BaP) is a polycyclic aromatic hydrocarbon (PAH) classified by the International Agency for Research on Cancer (IARC) as a group 1 carcinogen. BaP is formed as a product of incomplete combustion and is found in tobacco smoke as well as...