Search Results

87 results

  1. CORESTA Meeting, Smoke Science/Product Technology, 2019, Hamburg, ST 44

    Lung biomarkers of harm/effect for tobacco regulatory research: opportunities and challenges – a literature review

    MAKENA P.(1); EDMISTON J.(2); BEATTIE E.(3); MASON E.(4); McEWAN M.(5); PRASAD K.(5)
    (1) RAI Services Company, Winston-Salem, NC, U.S.A.; (2) Altria Client Services LLC, Richmond, VA, U.S.A.; (3) Cliantha Research Limited, Canada; (4) Imperial Brands PLC, Bristol, U.K.; (5) British American Tobacco (Investments) Limited, Southampton, U.K.
    Biomarkers of potential harm (BoPH) are indicators of biological perturbations in response to smoking, which may contribute to smoking-related disease. In this review, a project of the CORESTA Biomarkers Sub-Group, we critically assessed the available ...
  2. CORESTA Meeting, Smoke Science/Product Technology, 2019, Hamburg, ST Sustainability Forum

    Smoke-Techno Sustainabilty Forum

    RUSSELL C.(1); THOMPSON J.(2); RAVERDY-LAMBERT D.(3); MÜHLBACHER I.(4)
    (1) Centre for Substance Use Research (CSUR), Glasgow, Scotland, U.K.; (2) Imperial Brands PLC, Bristol, U.K.; (3) SWM International, Le Mans, France; (4) Ökolab, Vienna, Austria
    In 2015, the United Nations published 17 sustainable development goals and their corresponding targets to be achieved by 2030. Like other sectors, the tobacco and alternative product sectors are likely to impact most of the goals. Consequently, it is ...
  3. CORESTA Meeting, Smoke Science/Product Technology, 2019, Hamburg, STPOST 18 (also presented at TSRC 2019)

    Comparison of a flame ionization detector (GC/FID) to a nitrogen-phosphorus detector (GC/NPD) for gas chromatographic determination of nicotine in conventional and ultra-low nicotine tobacco blends

    STINSON A.; STEELMAN D.; CLARK T.J.
    Liggett Group LLC, 100 Maple Lane Mebane NC, U.S.A.
    The established CORESTA method to determine nicotine in tobacco uses a gas chromatograph coupled with a flame ionization detector (GC/FID) (CRM 62) that uses mass spectrometry (GC/MS) (CRM 87). These methods were developed to evaluate conventional tobacco ...
  4. CORESTA Meeting, Smoke Science/Product Technology, 2019, Hamburg, STPOST 33

    Quantitative risk assessment (QRA) indicates reduced risk potential for carcinogenic and non-carcinogenic effects of the aerosol of the next generation products (NGPs) compared to reference cigarettes

    AYALA-FIERRO F.(1); CZEKALA L.(2); SIMMS L.(2); RUDD K.(2); CAVA G.(2); STEVENSON M.(2)
    (1) ITG Brands LLC, Greensboro, NC, U.S.A.; (2) Imperial Brands PLC, Bristol, U.K.
    In order to understand the potential relative health risks of NGPs compared to cigarettes, we compared the relative risks of aerosols from tobacco-containing and tobacco-free NGPs to the smoke generated from a reference cigarette. Quantitative Risk ...
  5. CORESTA Meeting, Smoke Science/Product Technology, 2019, Hamburg, STPOST 34

    Next generation product aerosols induce lower biological activity than combusted cigarettes: a comparison of in vitro cell migration in the scratch wound assay

    RUDD K.(1); BUDDE J.(2); TRELLES STICKEN E.(2); WIECZOREK R.(2); SIMMS L.(1); STEVENSON M.(1)
    (1) Imperial Brands PLC, Bristol, U.K.; (2) Reemtsma Cigarettenfabriken GmbH (an Imperial Brands PLC Company), Hamburg, Germany
    Smoking combustible cigarettes is a cause of serious diseases in smokers, including heart disease. There are many commercially available next generation products (NGPs), such as tobacco-free e-vapour products, aiming to provide an alternative to smoking ...
  6. CORESTA Meeting, Smoke Science/Product Technology, 2019, Hamburg, STPOST 49

    The CORESTA in vitro test battery for combustible tobacco products: update from the 2004 Rationale and Strategy Report

    LEE K.M.(1); JORDAN K.G.(2); WIECZOREK R.(3); MOENNIKES O.(4); CLEMENTS J.(5); CROOKS I.(6); HASHIZUME T.(7); MILLER J.(8); WEBER E.(9); YOSHINO K.(7)
    (1) Altria Client Services, Richmond, VA, U.S.A.; (2) RAI Services Company, Winston-Salem, NC, U.S.A.; (3) Imperial Brands, Reemtsma Cigarettenfabriken GmbH, Hamburg, Germany; (4) PMI R&D, Philip Morris Products S.A., Neuchâtel, Switzerland; (5) Covance Laboratories Ltd, Harrogate, U.K.; (6) British American Tobacco (Investments) Ltd, R&D, Southampton, U.K.; (7) Japan Tobacco Inc., Yokohama, Kanagawa, Japan; (8) JT International SA, Geneva, Switzerland; (9) Ökolab, Vienna, Austria
    In 2004, the CORESTA In Vitro Toxicity Task Force issued a rationale and strategy report, commonly known as “the CORESTA in vitro test battery guideline”. The goals of this guideline were to: 1) develop the rationale and strategy for conducting in vitro ...
  7. CORESTA Meeting, Smoke Science/Product Technology, 2019, Hamburg, STW 01

    The application of in vitro Toxicity Testing in 21 Century (TT21C) for next generation products

    SIMMS L.(1); TRELLES STICKEN E.(2)
    (1) Imperial Brands PLC, Bristol, U.K.; (2) Reemtsma Cigarettenfabriken GmbH (an Imperial Brands PLC Company), Hamburg, Germany
    The aim is to demonstrate the feasibility of TT21C in vitro methods as part of an overall assessment framework for next generation products (NGP). TT21C methodologies can be used to assess harm reduction potential of NGPs using human-derived cellular ...
  8. TSRC, Tob. Sci. Res. Conf., 2019, 73, abstr. 034 (also presented at CORESTA SSPT2019)

    Comparison of a flame ionization detector (GC/FID) to a nitrogen-phosphorus detector (GC/NPD) for gas chromatographic determination of nicotine in conventional and ultra-low nicotine tobacco blends

    STEELMAN D.; STINSON A.; CLARK T.J.
    Liggett Group, Mebane, NC, USA
    The established CORESTA method to determine nicotine in tobacco uses a gas chromatograph coupled with a flame ionization detector (GC/FID) (CRM 62) or that uses a mass spectrometer (GC/MS) (CRM 87). These methods were developed to evaluate conventional ...
  9. CORESTA Congress, Kunming, 2018, Agronomy/Phytopathology Groups, APPOST 30

    Nicotine reduction and consumer perception: a scientific approach for quantifying possible impact of low nicotine cigarettes on consumer behaviour

    GUO Mengran(1); VERRON T.(1); DORLHAC de BORNE F.(2); PRITCHARD J.(3); COLARD S.(1)
    (1) SEITA - Imperial Brands plc, Paris, France; (2) Imperial Tobacco Limited, Leaf Research, Bergerac, France; (3) Imperial Brands, Bristol, U.K.
    In 2015, the WHO Study Group on Tobacco Product Regulation (TobReg) issued an advisory note recommending a strategy to reduce nicotine in tobacco to levels which would not be sufficient to lead to the development and/or maintenance of addiction. In the US ...