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38 results

  1. TSRC, Tob. Sci. Res. Conf., 2014, 68, abstr. 35

    Comparison of the in vitro toxicity profiles of e-cigarettes, tobacco-burning cigarettes, smokeless tobacco, and nicotine replacement therapy products: e-liquids, extracts, and aerosols

    LEVERETTE R.D.; MISRA M.; COOPER B.T.; BENNETT M.B.
    Lorillard Tobacco Company, A.W. Spears Research Center, Greensboro, North Carolina, USA
    The popularity and use of electronic cigarettes (e-cigarettes) continues to increase worldwide, in parallel with an accumulating body of scientific information on their potential toxicity and safety. In order to determine and compare the toxicity of e ...
  2. TSRC, Tob. Sci. Res. Conf., 2014, 68, abstr. 55

    Evaluation of the potential for second-hand exposure to e-cigarette aerosol in an office environment

    ROBINSON E.A.; LEVERETTE R.D.; MISRA M.
    Lorillard Tobacco Company, Greensboro, North Carolina, USA
    While several published studies have described the potential for second-hand exposure to e-cigarette aerosol, their designs have not been ideal for fully characterizing the impact of e-cigarette use on indoor environments. This study was designed to ...
  3. TSRC, Tob. Sci. Res. Conf., 2014, 68, abstr. 72

    Comparison of select analytes in aerosol from e-cigarettes with smoke from a conventional cigarette and with ambient air

    TAYYARAH R.; STEVENS R.D.; SMITH T.M.
    Lorillard Tobacco Company, Greensboro, North Carolina, USA
    Popular commercial electronic and conventional cigarettes were evaluated using smoking machines and standard puffing regimes to compare nicotine delivery and relative yields of chemical constituents for which cigarette smoke is routinely tested. ISO 17025 ...
  4. TSRC, Tob. Sci. Res. Conf., 2014, 68, abstr. 73

    Comparison of select analytes in exhaled aerosol from e-cigarettes with exhaled smoke from a traditional cigarette and exhaled breaths

    LONG G.A.; SMITH T.M.; STEVENS R.D.
    Lorillard Tobacco Company, Greensboro, North Carolina, USA
    Exhaled aerosols were collected following the use of two leading US commercial electronic cigarettes and a conventional cigarette by human subjects and analyzed for phenolics, carbonyls, water, glycerin and nicotine using a vacuum-assisted filter pad ...
  5. CORESTA Meeting, Smoke Science/Product Technology, 2013, Seville, ST 59

    Multiple point in time evaluation of commercial and reference cigarette products for abbreviated HPHC yield for mainstream smoke and filler

    TAYYARAH R.
    Lorillard Tobacco Company, Inc., Greensboro, NC, U.S.A.
    United States statutory requirements under The Family Smoking Prevention and Tobacco Control Act require that the FDA establish a list of all constituents identified by the FDA as harmful or potentially harmful (HPHC), that the FDA establish regulatory ...
  6. Beitr. Tabakforsch. Int./Contrib. Tob. Research, 2010, 24-1, p. 2-9., ISSN.0173-783X

    In vitro toxicological evaluation of cigarette smoke particulate matter: effect of dimethyl sulfoxide (DMSO) as solvent.

    MISRA M.; LEVERETTE R.D.; HAMM J.T.; & al.
    Lorillard Tobacco Company, A.W. Spears Research Center, Greensboro, NC, USA
    This study examined the potential to minimize the cytotoxic or genotoxic effects that dimethylsulfoxide (DMSO), when used as solvent, has on the in vitro interleukin-8 (IL-8) release, mammalian cell cytotoxicity and micronuclei formation, and bacterial ...
  7. TSRC, Tob. Sci. Res. Conf., 2010, 64, abstr. 17

    Comparison of the bacterial mutagenicity of whole-smoke, gas-vapor phase and smoke condensates from mentholated and non-mentholated cigarettes

    LEVERETTE R.
    Lorillard Tobacco Company, A.W. Spears Research Center, Greensboro, NC, USA
    Menthol is widely used in the pharmaceutical, cosmetic, food and tobacco industries and is generally regarded as sale (GRAS) for these applications. Menthol itself is non-mutagenic in the Ames Assay. This study was conducted to compare the mutagenicity of ...
  8. TSRC, Tob. Sci. Res. Conf., 2010, 64, abstr. 38

    Influence of menthol on the permeability of artificial cell membranes to acrolein, benzo(a)pyrene (bap), and 4-(methylnitrosamino)- 1-(3-pyridyl)-1-butanone (NNK)

    ROBINSON E.A.; PERINI F.R.
    Lorillard Tobacco Company, Greensboro, NC, USA
    Azzi et al. (Carcinogenesis 2006) explored the impact of menthol on membrane permeability in a porcine esophagus model. The authors found that menthol did not affect the permeation of test compounds, but did increase the membrane reservoir formation for ...