Search Results

3 results

  1. CORESTA Congress, Kunming, 2018, Smoke Science/Product Technology Groups, STPOST 62

    Nasal mucociliary clearance is a physiologically-relevant biomarker of tobacco effect/potential harm

    MAKENA P.; BAXTER S.; JONES B.A.; EVANS E.H.; CHEN P.; KREBS H.; GILL R.K.; PRASAD G.L.
    RAI Services Company, Winston-Salem, NC, U.S.A.
    Chronic cigarette smoking increases the risk of several diseases including chronic obstructive pulmonary disease (COPD). The pathophysiology of COPD can be attributed to multiple components: mucociliary dysfunction, airway inflammation and structural ...
  2. TSRC, Tob. Sci. Res. Conf., 2018, 72, abstr. 074

    Urinary leukotriene E4 and 2,3-dinor thromboxane B2 are potential biomarkers of effect for tobacco product evaluations

    MAKENA P.; LIU Gang; NOURI N.; CHEN P.; PRASAD G.L.
    RAI Services Company, Winston-Salem, NC, USA
    Adverse health outcomes from cigarette smoking generally take several decades to develop. Physiologically-relevant biomarkers of effect (BioEff), such as FEV1, typically require sustained smoking abstinence over several months to detect a significant ...