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6 results

  1. CORESTA Meeting, Smoke Science/Product Technology, 2019, Hamburg, STPOST 50 (also presented at TSRC 2019)

    Altered lung barrier function is a physiologically-relevant biomarker of potential harm

    MAKENA P.; BAXTER-WRIGHT S.; CHEN P.; PRASAD G.L.
    RAI Services Company, Winston Salem, NC, U.S.A.
    Cigarette smoking is a major risk factor for diseases including cardiovascular disease, lung cancer, and chronic obstructive pulmonary disease (COPD). One of the key functions of lung epithelial cells is to serve as a physical barrier against insults...
  2. TSRC, Tob. Sci. Res. Conf., 2019, 73, abstr. 015

    Levels of endothelial progenitor cells (EPCs) in smokers and moist snuff consumers

    ARIMILLI S.(1); CHEN P.(2); PRASAD G.L.(2)
    (1) Eurofins Professional Scientific Services, Winston Salem, NC, USA; (2) RAI Services Company, Winston Salem, NC, USA
    Endothelial progenitor cells (EPCs) are a key cell type present in circulation and are reported to play a role in the development of cardiovascular diseases. EPCs are derived from the bone marrow and mediate the differentiation, regeneration and...
  3. TSRC, Tob. Sci. Res. Conf., 2019, 73, abstr. 084 (also presented at CORESTA SSPT2019)

    Altered lung barrier function is a physiologically-relevant biomarker of potential harm

    MAKENA P.; BAXTER-WRIGHT S.; CHEN P.; PRASAD G.L.
    RAI Services Company, Winston Salem, NC, USA
    Cigarette smoking is a major risk factor for diseases including cardiovascular disease, lung cancer, and COPD. One of the key functions of lung epithelial cells is to serve as a physical barrier against insults including cigarette smoke. Chronic...
  4. CORESTA Congress, Kunming, 2018, Smoke Science/Product Technology Groups, STPOST 62

    Nasal mucociliary clearance is a physiologically-relevant biomarker of tobacco effect/potential harm

    MAKENA P.; BAXTER S.; JONES B.A.; EVANS E.H.; CHEN P.; KREBS H.; GILL R.K.; PRASAD G.L.
    RAI Services Company, Winston-Salem, NC, U.S.A.
    Chronic cigarette smoking increases the risk of several diseases including chronic obstructive pulmonary disease (COPD). The pathophysiology of COPD can be attributed to multiple components: mucociliary dysfunction, airway inflammation and structural...
  5. TSRC, Tob. Sci. Res. Conf., 2018, 72, abstr. 074

    Urinary leukotriene E4 and 2,3-dinor thromboxane B2 are potential biomarkers of effect for tobacco product evaluations

    MAKENA P.; LIU Gang; NOURI N.; CHEN P.; PRASAD G.L.
    RAI Services Company, Winston-Salem, NC, USA
    Adverse health outcomes from cigarette smoking generally take several decades to develop. Physiologically-relevant biomarkers of effect (BioEff), such as FEV1, typically require sustained smoking abstinence over several months to detect a significant...