Search Results

213 results

  1. CORESTA Meeting, Agronomy/Phytopathology, 2019, Victoria Falls, AP 52

    Changes in TSNA contents and sensory quality of ultra-low nicotine tobacco leaves produced by grafting with eggplant

    REN Mengjuan(1); SHI Hongzhi(1); LI Hongliang(2); ZHOU Jun(3); TANG Chaoqi(3); BAI Ruoshi(3); ZHANG Mengyue(1)
    (1) College of Tobacco Science of Henan Agricultural University / Tobacco Cultivation Key Laboratory of China Tobacco / Tobacco Harm Reduction Research Center of HAU, Zhengzhou, P.R. China; (2) Xuchang Tobacco Company of Henan, P.R. China; (3) Shanghai Tobacco (Group) Co., Ltd., Shanghai, P.R. China
    Ultra-low nicotine tobacco production has been given broad attention due to the possible regulation of nicotine content in cigarette tobacco. Based on grafting with eggplant (eggplant as rootstock, flue-cured variety Yunyan 87 as scion), the feeding...
  2. CORESTA Meeting, Agronomy/Phytopathology, 2019, Victoria Falls, APPOST 02

    Effects of spraying exogenous glycerol and molybdate on nitrate accumulation in pot-grown Burley tobacco leaves

    FENG Yuqing(1); SHI Hongzhi(1); LI Yafei(1,2); ZHOU Jun(3)
    (1) College of Tobacco Science of Henan Agricultural University, Tobacco Harm Reduction Research Center, Zhengzhou, P.R. China; (2) Henan Institute of Economics and Trade, Zhengzhou, P.R. China; (3) Beijing Cigarette Factory, Shanghai Tobacco Group Co., Ltd., Beijing, P.R. China
    Burley tobacco is well known as yellow-green leaf tobacco with reduced chlorophyll content and lower carbohydrate accumulation and lower nitrogen assimilation ability, resulting in the accumulation of nitrate, one of the precursors of TSNAs....
  3. CORESTA Meeting, Agronomy/Phytopathology, 2019, Victoria Falls, APPOST 03

    Effect of delaying harvest on tobacco quality of upper six leaves and climatic requirement in central Henan of China

    GAO Zhenzhen(1); YANG Mingkun(1); LIU Kouzhu(1); LI Jianhua(2); LI Hongliang(2); ZHANG Bingzhuo(1); SHI Hongzhi(1)
    (1) College of Tobacco Science of Henan Agricultural University, Tobacco Cultivation Key Laboratory of China Tobacco, Zhengzhou, P.R. China; (2) Xuchang Tobacco Company of Henan Provincial, Xuchang, Henan, P.R. China
    Upper tobacco leaves have higher quality potential and play an important role in low tar cigarette production. Upper leaves being rich in organic matter and tight in structure, high maturity is the key to produce high quality cured leaves. According...
  4. CORESTA Meeting, Smoke Science/Product Technology, 2019, Hamburg, ST 44

    Lung biomarkers of harm/effect for tobacco regulatory research: opportunities and challenges – a literature review

    MAKENA P.(1); EDMISTON J.(2); BEATTIE E.(3); MASON E.(4); McEWAN M.(5); PRASAD K.(5)
    (1) RAI Services Company, Winston-Salem, NC, U.S.A.; (2) Altria Client Services LLC, Richmond, VA, U.S.A.; (3) Cliantha Research Limited, Canada; (4) Imperial Brands PLC, Bristol, U.K.; (5) British American Tobacco (Investments) Limited, Southampton, U.K.
    Biomarkers of potential harm (BoPH) are indicators of biological perturbations in response to smoking, which may contribute to smoking-related disease. In this review, a project of the CORESTA Biomarkers Sub-Group, we critically assessed the...
  5. CORESTA Meeting, Smoke Science/Product Technology, 2019, Hamburg, ST 45

    Meta-analysis of two biomarkers of exposure of tobacco products

    AYALA-FIERRO F.(1); ELAMIN A.(2); FROST-PINEDA K.(3); JIN T.(3); PRASAD G.L.(3); SARKAR M.(4); SCHMIDT E.(3); VERRON T.(5)
    (1) ITG Brands LLC, Greensboro, NC, U.S.A.; (2) PMI R&D, Philip Morris Products S.A., Neuchâtel, Switzerland; (3) RAI Services Company, Winston-Salem, NC, U.S.A.; (4) Altria Client Services LLC, Richmond, VA, U.S.A.; (5) SEITA - Imperial Brands, Paris, France
    In the context of tobacco products, broadly two types of biomarkers exist, biomarkers of exposure (BoE) and biomarkers of potential harm (BoPH). BoE measure exposure to tobacco constituents, e.g. carbon monoxide (CO) and nicotine equivalents (NEQs)....
  6. CORESTA Meeting, Smoke Science/Product Technology, 2019, Hamburg, STPOST 42

    Characterization of whole mainstream smoke/aerosol delivery within the Vitrocell® Ames 48 high throughput exposure module using different tobacco product types

    LEVERETTE R.(1); KEYSER B.(1); SEYMOUR A.(2); HOLLINGS M.(2)
    (1) RAI Services Company, Scientific & Regulatory Affairs, Winston-Salem, NC, U.S.A.; (2) Covance Laboratories Ltd, Otley Road, Harrogate, North Yorkshire, U.K.
    The preferred means of assessing combustible or other aerosol-generating tobacco products in vitro is by direct exposure of cell cultures to freshly generated whole mainstream smoke/aerosols. This approach eliminates the fractionation of...
  7. CORESTA Meeting, Smoke Science/Product Technology, 2019, Hamburg, STPOST 49

    The CORESTA in vitro test battery for combustible tobacco products: update from the 2004 Rationale and Strategy Report

    LEE K.M.(1); JORDAN K.G.(2); WIECZOREK R.(3); MOENNIKES O.(4); CLEMENTS J.(5); CROOKS I.(6); HASHIZUME T.(7); MILLER J.(8); WEBER E.(9); YOSHINO K.(7)
    (1) Altria Client Services, Richmond, VA, U.S.A.; (2) RAI Services Company, Winston-Salem, NC, U.S.A.; (3) Imperial Brands, Reemtsma Cigarettenfabriken GmbH, Hamburg, Germany; (4) PMI R&D, Philip Morris Products S.A., Neuchâtel, Switzerland; (5) Covance Laboratories Ltd, Harrogate, U.K.; (6) British American Tobacco (Investments) Ltd, R&D, Southampton, U.K.; (7) Japan Tobacco Inc., Yokohama, Kanagawa, Japan; (8) JT International SA, Geneva, Switzerland; (9) Ökolab, Vienna, Austria
    In 2004, the CORESTA In Vitro Toxicity Task Force issued a rationale and strategy report, commonly known as “the CORESTA in vitro test battery guideline”. The goals of this guideline were to: 1) develop the rationale and strategy for conducting in...
  8. CORESTA Meeting, Smoke Science/Product Technology, 2019, Hamburg, STPOST 50 (also presented at TSRC 2019)

    Altered lung barrier function is a physiologically-relevant biomarker of potential harm

    MAKENA P.; BAXTER-WRIGHT S.; CHEN P.; PRASAD G.L.
    RAI Services Company, Winston Salem, NC, U.S.A.
    Cigarette smoking is a major risk factor for diseases including cardiovascular disease, lung cancer, and chronic obstructive pulmonary disease (COPD). One of the key functions of lung epithelial cells is to serve as a physical barrier against insults...
  9. CORESTA Meeting, Smoke Science/Product Technology, 2019, Hamburg, STPOST 51

    Structural investigation of the tobacco specific urinary biomarker iPX

    SCHMIDT E.; PRASAD G.L.
    RAI Services Company, Scientific & Regulatory Affairs, Winston-Salem, NC, U.S.A.
    Biomarkers of potential harm (BoPH) are tools to assess biological and pathophysiological effects associated with chronic tobacco product use, such as oxidative stress. Isoprostanes are widely recognized as BoPH for assessing endogenous oxidative...
  10. CORESTA Meeting, Smoke Science/Product Technology, 2019, Hamburg, STPOST 52 (also presented at TSRC 2019)

    A blood-based smoking-related gene expression signature using a machine learning approach

    LIU G.; PRASAD G.L.
    RAI Services Company, Winston-Salem, NC, U.S.A.
    Smoking is a leading risk factor in the onset of multiple forms of cancer, chronic obstructive pulmonary disease, and cardiovascular disease. At present, there is a limited understanding by which changes in gene expression profiles in blood or other...