Search Results

110 results

  1. CORESTA Meeting, Smoke Science/Product Technology, 2019, Hamburg, ST 18

    Human precision-cut lung slices as a screening tool: increased throughput, cryopreservation, and detection of DNA adducts for next generation tobacco product evaluation

    BEHRSING H.P.(1); DESAI P.(1); AMIN K.(2); BALBO S.(3); HECHT S.S.(2); SHEEHAN D.(1); CASTRO N.(1); ALLEN D.(4)
    (1) Institute for In Vitro Sciences, Inc., Gaithersburg, MD, U.S.A.; (2) University of Minnesota, Division of Environmental Health Sciences, Minneapolis, MN, U.S.A.; (3) University of Minnesota, Department of Laboratory Medicine and Pathology, Minneapolis, MN, U.S.A.; (4) Integrated Laboratory Systems, Inc., Morrisville, NC, U.S.A.
    Human-relevant, in vitro/ex vivo assays are considered an ethical and economically viable manner by which to screen the many chemicals requiring hazard assessment, such as next generation tobacco product (NGTP) ingredients. Human precision-cut lung slices ...
  2. CORESTA Meeting, Smoke Science/Product Technology, 2019, Hamburg, STPOST 36

    Use of ex vivo precision-cut lung slices as a screening tool for potential respiratory toxicity of e-liquids

    BEHRSING H.P.(1); SHEEHAN D.(1); AMIN K.(2); LEE K.M.(3); OLDHAM M.(4); RAABE H.(1)
    (1) Institute for In Vitro Sciences, Inc., Gaithersburg, MD, U.S.A.; (2) University of Minnesota, Minneapolis, MN, U.S.A.; (3) Altria Client Services, Richmond, VA, U.S.A.; (4) former Altria Client Services employee
    The Family Smoking Prevention and Tobacco Control Act gave the FDA regulatory authority over next generation tobacco products (NGTP) such as e-vapor products. E-vapor product liquids contain a variety of ingredient combinations that should be assessed for ...
  3. CORESTA Meeting, Smoke Science/Product Technology, 2019, Hamburg, STPOST 47

    Identification, discussion and recommendations for the optimal generation and use of in vitro genotoxicity assay data for tobacco and nicotine products

    DESAI P.(1); CURREN R.(1); MOORE M.M.(2)
    (1) Institute for In Vitro Sciences, Gaithersburg, MD, U.S.A.; (2) Ramboll Environ Inc., Little Rock, AR, U.S.A.
    The Institute for In Vitro Sciences is sponsoring a series of workshops to identify, discuss and develop recommendations for optimal scientific/technical approaches for utilizing in vitro regulatory genotoxicity assay data within and across tobacco and ...
  4. TSRC, Tob. Sci. Res. Conf., 2019, 73, abstr. 008

    Workshop series to identify, discuss and develop recommendations for the optimal generation and use of in vitro genotoxicity assay data for tobacco and nicotine products

    MOORE M.M.(1); CURREN R.(2)
    (1) Ramboll US Corporation, Little Rock, AR, USA; (2) Institute for In Vitro Sciences, Gaithersburg, MD, USA
    The Institute for In Vitro Sciences is sponsoring a series of workshops to identify, discuss and develop recommendations for optimal scientific/technical approaches for utilizing in vitro regulatory genotoxicity assay data within and across tobacco and ...
  5. CORESTA Congress, Berlin, 2016, Smoke Science/Product Technology Groups, STPOST 33

    Accurate and reproducible dispensing of patterned picoliter quantities of tobacco extract onto apical surfaces of human 3D reconstructed airway tissues

    BEHRSING H.(1); SADOWSKI N.(1); CONSTANT S.(2); HUANG S.(2); RAABE H.(1)
    (1) Institute for In Vitro Sciences, Inc., Gaithersburg, MD, U.S.A.; (2) Epithelix Sàrl, Geneva, Switzerland
    There is an increasing need for researchers to understand the dynamic aspects of inhaled tobacco product exposure. Exposure-induced events can cause respiratory irritation, sensitisation, and other events that may lead to severe pulmonary disease. ...
  6. TSRC, Tob. Sci. Res. Conf., 2015, 69, abstr. 109

    3d reconstructed human airway models: effect of acclimation conditions on biomarker and inflammatory response following tissue challenge

    BEHRSING H.; RAABE H.A.; SHEEHAN D.W.; SLY E.A.; CURREN R.D.
    Institute for In Vitro Sciences, Gaithersburg, MD USA
    Human reconstructed, 3-dimensional (3D) airway tissues present researchers with organotypic models that consist of heterogenous cell types that more accurately reflect the pulmonary airway in vivo. These in vitro models are now increasingly applied to ...
  7. CORESTA Congress, Quebec, 2014, Smoke Science/Product Technology Groups, ST 15

    Evaluation of the EpiOral™ reconstructed human oral buccal tissue model as a testing platform for determining the oral irritation potential of tobacco products

    RAABE H.; BARNES N.; HILBERER A.
    Institute for In Vitro Sciences, Inc., Gaithersburg, MD, U.S.A.
    There is an increasing need by the tobacco industry to evaluate the oral/buccal irritation potential of tobacco products both to support product development goals and for sound product stewardship. The use of in vitro human cell and tissue-based test ...
  8. TSRC, Tob. Sci. Res. Conf., 2014, 68, abstr. 05

    The use of precision-cut lung slices to assess inflammation, parenchymal damage, and collagen deposition: three markers of tobacco exposure-induced pulmonary toxicity

    BEHRSING H.P.
    Institute for In Vitro Sciences, Inc., Gaithersburg, Maryland, USA
    The Family Smoking Prevention and Tobacco Control Act (TCA) gives the Food and Drug Administration (FDA) broad authority to regulate tobacco products. The FDA-Center for Tobacco Products (CTP) calls for several research priority areas, including in vitro ...
  9. CORESTA Meeting, Agronomy/Phytopathology, 2013, Brufa di Torgiano, APPOST 01

    Performance of fire-cured tobacco with compost from urban sources

    COZZOLINO E.; LEONE V.; LOMBARDI P.
    Consiglio per la Ricerca e la Sperimentazione in Agricoltura - Unità di Ricerca per le Colture Alternative al Tabacco (CRA-CAT), Scafati (SA), Italy
    A two-year trial of Kentucky fire-cured tobacco fertilisation with compost from urban organic waste was conducted with three cultivars (Foiano, Riccio beneventano and SKL) on two farms in the province of Benevento (Italy). A commercial compost, produced ...
  10. CORESTA Meeting, Agronomy/Phytopathology, 2013, Brufa di Torgiano, APPOST 04

    Influence of plant density and leaf priming collection on seed and seed oil yield in tobacco

    BUCCIARELLI S.(1); CIVITELLA D.(1); FECONDO G.(1); GHIANNI G.(1); SORRENTINO C.(2); DEL PIANO L.(2); RAIMO F.(2); STANISCI V.(3)
    (1) Consorzio per la Divulgazione e la Sperimentazione delle Tecniche Irrigue (CO.T.IR), Vasto (CH), Italy; (2) Consiglio per la Ricerca e la Sperimentazione in Agricoltura - Unità di Ricerca per le Colture Alternative al Tabacco (CRA-CAT), Scafati (SA), Italy; (3) ECOFOX, Vasto (CH), Italy
    In the EU the Common Agricultural Policy (CAP) reform of 2004 has established a gradual reduction in incentives for the production of tobacco. In Italy there was a reduction of about 30% of the area under tobacco cultivation from 2000 to 2010. Value-added ...