Search Results

77 results

  1. CORESTA Congress, Kunming, 2018, Smoke Science/Product Technology Groups, ST 62

    Immune functions are perturbed to a greater extent with smoking rather than moist snuff use

    TRAN Q.T.(1); ARIMILLI S.(2); JOHNSON E.(3); LIU Gang(1); PRASAD G.L.(1)
    (1) RAI Services Company, Winston-Salem, NC, U.S.A.; (2) Wake Forest University, School of Medicine, Department of Microbiology and Immunology, Winston-Salem, NC, U.S.A.; (3) University of North Carolina, Department of Mathematics and Statistics, Greensboro, NC, U.S.A.
    Cigarette smoking is a major risk factor for lung cancer, chronic obstructive pulmonary disease, and cardiovascular disease (CVD). Existing epidemiological data suggest moist snuff consumption is generally associated with reduced health risks relative to ...
  2. TSRC, Tob. Sci. Res. Conf., 2018, 72, abstr. 066

    Distinct gene expression changes in peripheral blood mononuclear cells exposed to combustible versus non-combustible tobacco product preparations

    TRAN N.Q.(1); ARIMILLI S.(2); MADAHIAN B.(3); HOMAYOUNI R.(3); PRASAD G.L.(1)
    (1) RAI Services, Winston-Salem, NC, USA; (2) Wake Forest University, Winston-Salem, NC, USA; (3) Quire Inc., Memphis, TN, USA
    Cigarette smoking exerts diverse physiological effects including immune suppression. Existing epidemiological data show that consumption of smokeless tobacco products, such as moist snuff, is less harmful relative to smoking. We previously demonstrated ...
  3. TSRC, Tob. Sci. Res. Conf., 2018, 72, abstr. 080

    Differential gene expression and functional responses in peripheral blood mononuclear cells pretreated with combustible and non-combustible tobacco products

    TRAN Q.T.(1); ARIMILLI S.(2); LIU Gang(1); MAKENA P.(1); PRASAD G.L.(1)
    (1) RAI Services Company, Winston-Salem, NC, USA; (2) Wake Forest School of Medicine, Winston-Salem, NC, USA
    Chronic smoking is known to alter immune responses, which compromises tumor surveillance and host defense against microbial infections. We previously showed that smokers (SMK) exhibit distinct peripheral blood mononuclear cell (PBMC) gene expression ...
  4. CORESTA Meeting, Smoke Science/Product Technology, 2017, Kitzbühel, STPOST 19

    Combustible and smokeless tobacco product preparations differentially regulate calcium mobilization in the human leukemic HL60 cell line

    MAKENA P.(2); ARIMILLI S.(1); DAMRATOSKI B.E.(1); PRASAD G.L.(2)
    (1) Wake Forest University School of Medicine, Department of Microbiology & Immunology, Winston-Salem, NC, U.S.A.; (2) RAI Services Co., Winston-Salem, NC 27102, U.S.A.
    Increased calcium (Ca 2+) mobilization is central to leukocyte signaling and for regulation of immune responses. Although evidence suggests that cigarette smoking affects several biological functions including inflammatory responses, how the use of ...
  5. CORESTA Congress, Berlin, 2016, Agronomy/Phytopathology Groups, AP 46

    Effect of fertilisation with nitrogen, with or without the application of endomycorrhizae, in planting on the yield and quality of flue-cured tobacco

    TURŠIC I.(1); SLEZAK R.(2); RACZ A.(3); ŽALAC S.(4)
    (1) Tobacco Institute Zagreb, Croatia; (2) Bio-Budućnost d.o.o., Zagreb, Croatia; (3) University of Applied Health Sciences, Croatia; (4) Agrokontrola d.o.o., Zagreb, Croatia
    The effect of fertilisation with different amounts of nitrogen and the application of endomycorrhizae in planting on the yield and quality of tobacco were investigated in the experimental field of the Faculty of Agriculture in Zagreb. Studies were ...
  6. CORESTA Congress, Berlin, 2016, Agronomy/Phytopathology Groups, APPOST 09

    Performance of new breeding lines of flue-cured tobacco and their test-hybrids for economic traits

    BUDIMIR A.(1); ŠARCEVIC H.(2); KOŽIĆ K.(1)
    (1) Hrvatski duhani d.d. Virovitica (Croatian Tobaccos Inc.) / British American Tobacco (BAT), Virovitica, Croatia; (2) University of Zagreb, Faculty of Agriculture, Zagreb, Croatia
    During the 2014 and 2015 growing seasons a field trial with ten new breeding lines of flue-cured tobacco, their test-hybrids with two line testers, and two controls (the hybrid cultivar DH17 and the line cultivar NC55) was conducted in five environments ...
  7. CORESTA Congress, Berlin, 2016, Smoke Science/Product Technology Groups, STPOST 40

    Role of oxidative stress in the suppression of immune responses in peripheral blood mononuclear cells exposed to combustible tobacco product preparations

    PRASAD G.L.(1); ARIMILLI S.(2); DAMRATOSKI B.E.(2)
    (1) Scientific & Regulatory Affairs, RAI Services Company, Winston-Salem, U.S.A.; (2) Department of Microbiology & Immunology, Wake Forest University Health Sciences, U.S.A.
    Cigarette smoking is a major risk factor for several human diseases. Chronic inflammation, resulting from increased oxidative stress, has been suggested as a mechanism that contributes to the increased susceptibility of smokers to cancer and microbial ...
  8. TSRC, Tob. Sci. Res. Conf., 2016, 70, abstr. 17

    Ex vivo effects of smokeless tobacco extracts on select immune responses

    PRASAD G.L.(1); ARIMILLI S.(2); DAMRATOSKI B.E.(2); SCHMIDT E.(1); ROWE J.(3); CHOUCHANE S.(4)
    (1) RAI Services Company; (2) Wake Forest University Health Sciences; (3) R.J. Reynolds Tobacco Co.; (4) Eurofins Lancaster Labs Inc, Winston-Salem, NC, USA
    Our previous work demonstrated that exposure to Tobacco Product Preparations (TPPs) from combustible tobacco cause cytotoxic and select immunosuppressive effects in PBMCs, and this ex vivo model is well suited to investigate the chronic immune suppression ...
  9. CORESTA Congress, Quebec, 2014, Smoke Science/Product Technology Groups, ST 38

    Role of oxidative stress in the suppression of immune responses in peripheral blood mononuclear cells exposed to combustible tobacco product preparations

    ARIMILLI S.(1); DAMRATOSKI B.E.(1); PRASAD G.L.(2)
    (1) Department of Microbiology & Immunology, Wake Forest University School of Medicine, Winston-Salem, NC, U.S.A.; (2) R.J. Reynolds Tobacco Company, R&D Department, Winston-Salem, NC, U.S.A.
    Chronic cigarette smoking is known to adversely impact innate and adaptive immune responses, resulting in immunosuppression, which has been linked to increased susceptibility of smokers to microbial infections and higher incidences of cancer relative to ...
  10. TSRC, Tob. Sci. Res. Conf., 2013, 67, abstr. 19

    Tobacco product preparations differentially regulate human PBMC functions, including T cell and NK function.

    ARIMILLI S.(1); DAMRATOSKI B.E.(1); PRASAD G.L.(2)
    (1) Wake Forest University School of Medicine, Winston-Salem, NC, USA; (2) Reynolds Tobacco Company, Winston-Salem, NC, USA
    Natural Killer (NK) cells and T cells play essential roles in innate and adaptive immune responses in protecting against microbial infections and in tumor surveillance. Although evidence suggests that smoking causes immunosuppression, there is limited ...