Search Results

29 results

  1. CORESTA Congress, Kunming, 2018, Smoke Science/Product Technology Groups, ST 62

    Immune functions are perturbed to a greater extent with smoking rather than moist snuff use

    TRAN Q.T.(1); ARIMILLI S.(2); JOHNSON E.(3); LIU Gang(1); PRASAD G.L.(1)
    (1) RAI Services Company, Winston-Salem, NC, U.S.A.; (2) Wake Forest University, School of Medicine, Department of Microbiology and Immunology, Winston-Salem, NC, U.S.A.; (3) University of North Carolina, Department of Mathematics and Statistics, Greensboro, NC, U.S.A.
    Cigarette smoking is a major risk factor for lung cancer, chronic obstructive pulmonary disease, and cardiovascular disease (CVD). Existing epidemiological data suggest moist snuff consumption is generally associated with reduced health risks relative to ...
  2. TSRC, Tob. Sci. Res. Conf., 2018, 72, abstr. 066

    Distinct gene expression changes in peripheral blood mononuclear cells exposed to combustible versus non-combustible tobacco product preparations

    TRAN N.Q.(1); ARIMILLI S.(2); MADAHIAN B.(3); HOMAYOUNI R.(3); PRASAD G.L.(1)
    (1) RAI Services, Winston-Salem, NC, USA; (2) Wake Forest University, Winston-Salem, NC, USA; (3) Quire Inc., Memphis, TN, USA
    Cigarette smoking exerts diverse physiological effects including immune suppression. Existing epidemiological data show that consumption of smokeless tobacco products, such as moist snuff, is less harmful relative to smoking. We previously demonstrated ...
  3. TSRC, Tob. Sci. Res. Conf., 2018, 72, abstr. 080

    Differential gene expression and functional responses in peripheral blood mononuclear cells pretreated with combustible and non-combustible tobacco products

    TRAN Q.T.(1); ARIMILLI S.(2); LIU Gang(1); MAKENA P.(1); PRASAD G.L.(1)
    (1) RAI Services Company, Winston-Salem, NC, USA; (2) Wake Forest School of Medicine, Winston-Salem, NC, USA
    Chronic smoking is known to alter immune responses, which compromises tumor surveillance and host defense against microbial infections. We previously showed that smokers (SMK) exhibit distinct peripheral blood mononuclear cell (PBMC) gene expression ...
  4. CORESTA Meeting, Smoke Science/Product Technology, 2017, Kitzbühel, ST 53 (also presented at TSRC 2017)

    Fumex: light scattering sensor for the analysis of electronic cigarette aerosols

    WANG Q.(1); LI W.(2); LIPOWICZ P.(2); DUNKHORST W.(3); KOCH W.(3)
    (1) Eurofins Lancaster Laboratories, c/o Altria Client Services LLC, Research, Development and Regulatory Affairs, Richmond, VA, U.S.A.; (2) Altria Client Services LLC, Research, Development and Regulatory Affairs, Richmond, VA, U.S.A.; (3) Fraunhofer ITEM, Department of Aerosol Technology, Hannover, Germany
    A new sensor based on light scattering has been designed to perform highly time resolved measurements of the mass concentration and the mass median diameter (MMD) of aerosols formed in e-cigarettes. Aerosols generated in e-cigarettes are spherical, ...
  5. CORESTA Meeting, Smoke Science/Product Technology, 2017, Kitzbühel, STPOST 19

    Combustible and smokeless tobacco product preparations differentially regulate calcium mobilization in the human leukemic HL60 cell line

    MAKENA P.(2); ARIMILLI S.(1); DAMRATOSKI B.E.(1); PRASAD G.L.(2)
    (1) Wake Forest University School of Medicine, Department of Microbiology & Immunology, Winston-Salem, NC, U.S.A.; (2) RAI Services Co., Winston-Salem, NC 27102, U.S.A.
    Increased calcium (Ca 2+) mobilization is central to leukocyte signaling and for regulation of immune responses. Although evidence suggests that cigarette smoking affects several biological functions including inflammatory responses, how the use of ...
  6. CORESTA Congress, Berlin, 2016, Agronomy/Phytopathology Groups, AP 16

    Role of polyamines in leaf ripening of low alkaloid tobacco varieties

    NÖLKE G.(1); VOLKE D.(1); CHUDOBOVA I.(1); HOUDELET M.(1); LUSSO M.(2); FREDERICK J.(2); WAREK U.(2); STRICKLAND J.(2); XU D.(2); FISCHER R.(1); SCHINKEL H.(1); SCHILLBERG S.(1)
    (1) Fraunhofer Institute for Molecular Biology and Applied Ecology IME, Aachen, Germany; (2) Altria Client Services LLC, Research, Development and Regulatory Affairs, Richmond, VA, U.S.A.
    Traditional breeding and molecular approaches have been used to develop tobacco varieties with reduced nicotine and secondary alkaloid levels. However, low-alkaloid (LA) tobacco varieties often show impaired leaf ripening and senescence leading to poor ...
  7. CORESTA Congress, Berlin, 2016, Agronomy/Phytopathology Groups, AP 25

    Sucker control through biotechnology

    XU D.(1); GRUNDMANN L.(2); SHEN Y.(1); NOLL G.(2); YANG J.(1); KUDITHIPUDI C.(1); FREDERICK J.(1); PRUEFER D.(2); WAREK U.(1); STRICKLAND J.(1)
    (1) Altria Client Services LLC, Research, Development and Regulatory Affairs, Richmond, VA, U.S.A.; (2) Fraunhofer Institute for Molecular Biology and Applied Ecology IME, Muenster, Germany
    Tobacco plants exhibit strong apical dominance that effectively inhibits axillary bud development. However, upon shoot apical meristem removal (topping), loss of apical dominance quickly allows axillary buds to grow (suckers) resulting in yield loss and ...
  8. CORESTA Congress, Berlin, 2016, Smoke Science/Product Technology Groups, ST 24

    A CFD model for the smouldering combustion of the cellulosic substrate during the ignition propensity test

    GUINDOS P.(1); PATEL A.(1,2); KOLB T.(1)
    (1) Fraunhofer Institute for Molecular Biology and Applied Ecology IME, Aachen, Germany; (2) TU Braunschweig, Braunschweig, Germany
    An experimental and numerical investigation was conducted to characterise the influence of the cellulosic substrate used to assess the ignition propensity (IP) of cigarettes. The objective was to better understand the poor repeatability of the test and ...
  9. CORESTA Congress, Berlin, 2016, Smoke Science/Product Technology Groups, STPOST 40

    Role of oxidative stress in the suppression of immune responses in peripheral blood mononuclear cells exposed to combustible tobacco product preparations

    PRASAD G.L.(1); ARIMILLI S.(2); DAMRATOSKI B.E.(2)
    (1) Scientific & Regulatory Affairs, RAI Services Company, Winston-Salem, U.S.A.; (2) Department of Microbiology & Immunology, Wake Forest University Health Sciences, U.S.A.
    Cigarette smoking is a major risk factor for several human diseases. Chronic inflammation, resulting from increased oxidative stress, has been suggested as a mechanism that contributes to the increased susceptibility of smokers to cancer and microbial ...
  10. TSRC, Tob. Sci. Res. Conf., 2016, 70, abstr. 17

    Ex vivo effects of smokeless tobacco extracts on select immune responses

    PRASAD G.L.(1); ARIMILLI S.(2); DAMRATOSKI B.E.(2); SCHMIDT E.(1); ROWE J.(3); CHOUCHANE S.(4)
    (1) RAI Services Company; (2) Wake Forest University Health Sciences; (3) R.J. Reynolds Tobacco Co.; (4) Eurofins Lancaster Labs Inc, Winston-Salem, NC, USA
    Our previous work demonstrated that exposure to Tobacco Product Preparations (TPPs) from combustible tobacco cause cytotoxic and select immunosuppressive effects in PBMCs, and this ex vivo model is well suited to investigate the chronic immune suppression ...