Search Results

29 results

  1. CORESTA Congress, Kunming, 2018, Smoke Science/Product Technology Groups, ST 01

    In vitro biological safety evaluation of cigarette smoke

    CHEN Xi(1,2); SHEN Y.(1,2); CHEN Hongyu(1,2); LIU F.(1,2); QI H.(3); JIMIN S.(3); TIMKO M.(4); FAN L.(1,2)
    (1) Research Center for Air Pollution and Health, Zhejiang University, Hangzhou, P.R. China; (2) Institute of Bioinformatics, Zhejiang University, Hangzhou, P.R. China; (3) Department of Pathology and Pathophysiology, School of Basic Medical Sciences, Zhejiang University, Hangzhou, P.R. China; (4) Department of Public Health Sciences, School of Medicine, University of Virginia, Charlottesville, VA, U.S.A.
    Traditionally, toxicological evaluation of cigarette smoke has focused on the harmful chemical content of smoke. Harm-reduced cigarettes should not only refer to these chemical compounds, but also to the degree of the effect of whole smoke on human cells. ...
  2. CORESTA Congress, Kunming, 2018, Smoke Science/Product Technology Groups, ST 62

    Immune functions are perturbed to a greater extent with smoking rather than moist snuff use

    TRAN Q.T.(1); ARIMILLI S.(2); JOHNSON E.(3); LIU Gang(1); PRASAD G.L.(1)
    (1) RAI Services Company, Winston-Salem, NC, U.S.A.; (2) Wake Forest University, School of Medicine, Department of Microbiology and Immunology, Winston-Salem, NC, U.S.A.; (3) University of North Carolina, Department of Mathematics and Statistics, Greensboro, NC, U.S.A.
    Cigarette smoking is a major risk factor for lung cancer, chronic obstructive pulmonary disease, and cardiovascular disease (CVD). Existing epidemiological data suggest moist snuff consumption is generally associated with reduced health risks relative to ...
  3. TSRC, Tob. Sci. Res. Conf., 2018, 72, abstr. 066

    Distinct gene expression changes in peripheral blood mononuclear cells exposed to combustible versus non-combustible tobacco product preparations

    TRAN N.Q.(1); ARIMILLI S.(2); MADAHIAN B.(3); HOMAYOUNI R.(3); PRASAD G.L.(1)
    (1) RAI Services, Winston-Salem, NC, USA; (2) Wake Forest University, Winston-Salem, NC, USA; (3) Quire Inc., Memphis, TN, USA
    Cigarette smoking exerts diverse physiological effects including immune suppression. Existing epidemiological data show that consumption of smokeless tobacco products, such as moist snuff, is less harmful relative to smoking. We previously demonstrated ...
  4. TSRC, Tob. Sci. Res. Conf., 2018, 72, abstr. 080

    Differential gene expression and functional responses in peripheral blood mononuclear cells pretreated with combustible and non-combustible tobacco products

    TRAN Q.T.(1); ARIMILLI S.(2); LIU Gang(1); MAKENA P.(1); PRASAD G.L.(1)
    (1) RAI Services Company, Winston-Salem, NC, USA; (2) Wake Forest School of Medicine, Winston-Salem, NC, USA
    Chronic smoking is known to alter immune responses, which compromises tumor surveillance and host defense against microbial infections. We previously showed that smokers (SMK) exhibit distinct peripheral blood mononuclear cell (PBMC) gene expression ...
  5. CORESTA Meeting, Smoke Science/Product Technology, 2017, Kitzbühel, STPOST 19

    Combustible and smokeless tobacco product preparations differentially regulate calcium mobilization in the human leukemic HL60 cell line

    MAKENA P.(2); ARIMILLI S.(1); DAMRATOSKI B.E.(1); PRASAD G.L.(2)
    (1) Wake Forest University School of Medicine, Department of Microbiology & Immunology, Winston-Salem, NC, U.S.A.; (2) RAI Services Co., Winston-Salem, NC 27102, U.S.A.
    Increased calcium (Ca 2+) mobilization is central to leukocyte signaling and for regulation of immune responses. Although evidence suggests that cigarette smoking affects several biological functions including inflammatory responses, how the use of ...
  6. CORESTA Congress, Berlin, 2016, Smoke Science/Product Technology Groups, ST 35

    Development of a method for trace level analysis in the aerosol from a novel tobacco vaporiser

    MASUGI E.(1); SASAMOTO K.(2); OCHIAI N.(2); DAVID F.(3); SANDRA P.(3)
    (1) Japan Tobacco Inc. Tobacco Science Research Center, Yokohama, Kanagawa, Japan; (2) GERSTEL K.K., Tokyo, Japan; (3) Research Institute for Chromatography, Kortrijk, Belgium
    In some markets, a variety of tobacco vaporisers is commercially available. One of the characteristics of tobacco vaporisers is that the generated aerosol contains a lower number of combustion-derived chemicals due to the particular heating system which ...
  7. CORESTA Congress, Berlin, 2016, Smoke Science/Product Technology Groups, STPOST 40

    Role of oxidative stress in the suppression of immune responses in peripheral blood mononuclear cells exposed to combustible tobacco product preparations

    PRASAD G.L.(1); ARIMILLI S.(2); DAMRATOSKI B.E.(2)
    (1) Scientific & Regulatory Affairs, RAI Services Company, Winston-Salem, U.S.A.; (2) Department of Microbiology & Immunology, Wake Forest University Health Sciences, U.S.A.
    Cigarette smoking is a major risk factor for several human diseases. Chronic inflammation, resulting from increased oxidative stress, has been suggested as a mechanism that contributes to the increased susceptibility of smokers to cancer and microbial ...
  8. TSRC, Tob. Sci. Res. Conf., 2016, 70, abstr. 17

    Ex vivo effects of smokeless tobacco extracts on select immune responses

    PRASAD G.L.(1); ARIMILLI S.(2); DAMRATOSKI B.E.(2); SCHMIDT E.(1); ROWE J.(3); CHOUCHANE S.(4)
    (1) RAI Services Company; (2) Wake Forest University Health Sciences; (3) R.J. Reynolds Tobacco Co.; (4) Eurofins Lancaster Labs Inc, Winston-Salem, NC, USA
    Our previous work demonstrated that exposure to Tobacco Product Preparations (TPPs) from combustible tobacco cause cytotoxic and select immunosuppressive effects in PBMCs, and this ex vivo model is well suited to investigate the chronic immune suppression ...
  9. CORESTA Meeting, Smoke Science/Product Technology, 2015, Jeju, ST 36

    Comprehensive analysis of proteins in tobacco leaf

    MASUGI E.(1); ORTIZ A.(2); YOSHIMURA Y.(1); MITSUI K.(1); DAVID F.(2); SANDRA P.(2); SANDRA K.(2)
    (1) Japan Tobacco Inc., Tobacco Science Research Center, Yokohama, Kanagawa, Japan; (2) Research Institute for Chromatography, Kortrijk, Belgium
    In the last two decades, proteomics has been a vastly expanding field of research. Proteomics aims at the comprehensive and comparative measurement of the proteins present in a sample, e.g. plants. Major developments in separation and analytical sciences ...
  10. CORESTA Congress, Quebec, 2014, Smoke Science/Product Technology Groups, ST 38

    Role of oxidative stress in the suppression of immune responses in peripheral blood mononuclear cells exposed to combustible tobacco product preparations

    ARIMILLI S.(1); DAMRATOSKI B.E.(1); PRASAD G.L.(2)
    (1) Department of Microbiology & Immunology, Wake Forest University School of Medicine, Winston-Salem, NC, U.S.A.; (2) R.J. Reynolds Tobacco Company, R&D Department, Winston-Salem, NC, U.S.A.
    Chronic cigarette smoking is known to adversely impact innate and adaptive immune responses, resulting in immunosuppression, which has been linked to increased susceptibility of smokers to microbial infections and higher incidences of cancer relative to ...