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278 results

  1. CORESTA Congress, Kunming, 2018, Agronomy/Phytopathology Groups, AP 01 (also presented at TSRC 2018)

    FDA advance notice of proposed rulemaking for nicotine level of combusted cigarettes – feasibility for compliance via tobacco plant genetics?

    HIATT E.
    R.J. Reynolds Tobacco Co., Winston-Salem, NC, U.S.A.
    On March 16, 2018, the U.S. Food and Drug Administration (FDA) published an advance notice of proposed rulemaking (ANPRM) entitled “Tobacco Product Standard for Nicotine Level of Combusted Cigarettes.” The publication of an ANPRM solicits information and ...
  2. CORESTA Congress, Kunming, 2018, Smoke Science/Product Technology Groups, ST 62

    Immune functions are perturbed to a greater extent with smoking rather than moist snuff use

    TRAN Q.T.(1); ARIMILLI S.(2); JOHNSON E.(3); LIU Gang(1); PRASAD G.L.(1)
    (1) RAI Services Company, Winston-Salem, NC, U.S.A.; (2) Wake Forest University, School of Medicine, Department of Microbiology and Immunology, Winston-Salem, NC, U.S.A.; (3) University of North Carolina, Department of Mathematics and Statistics, Greensboro, NC, U.S.A.
    Cigarette smoking is a major risk factor for lung cancer, chronic obstructive pulmonary disease, and cardiovascular disease (CVD). Existing epidemiological data suggest moist snuff consumption is generally associated with reduced health risks relative to ...
  3. TSRC, Tob. Sci. Res. Conf., 2018, 72, abstr. 006

    Qualitative assessment of flavor ingredients in market electronic nicotine delivery systems

    HUDSON A.G.(1); CULBERT C.G.(2)
    (1) R.J. Reynolds Tobacco Company, Winston-Salem, NC, USA; (2) RAI Services Company, Winston-Salem, NC, USA
    As the use of electronic nicotine delivery systems (ENDS) grows, it may be useful to understand the types of flavor compounds that are being added as ingredients to the ENDS currently available on the market. A qualitative analysis of flavor compounds was ...
  4. TSRC, Tob. Sci. Res. Conf., 2018, 72, abstr. 013

    Method development for pH analysis of ends aerosol and e-liquid

    HEFNER T.(1); ST. CHARLES F.K.(2); ANDERSON J.(3)
    (1) R.J. Reynolds Tobacco Company, Winston Salem, NC, USA; (2) St.Charles Consultancy, Winston Salem, NC, USA; (3) Eurofins Lancaster Labs, Winston Salem, NC, USA
    E-liquids are hygroscopic, non-aqueous liquids containing a small amount of water (~3-15%). When the pH of a non-aqueous liquid is measured using conventional methods and calibration buffers, the value can only be regarded as an "apparent pH". ...
  5. TSRC, Tob. Sci. Res. Conf., 2018, 72, abstr. 017

    Development of a 3D human oral tissue model for oral permeation of smokeless moist snuff

    KEYSER B.(1); ROWE J.(2); WEIDMAN R.(2); FIELDS W.(1)
    (1) RAI Services Company, Winston-Salem, NC, USA; (2) R.J. Reynolds Tobacco Company, Winston-Salem, NC, USA
    Tobacco product use is a risk factor in the development of oral cancer, although epidemiology studies show this risk is far less with smokeless tobacco product use than cigarette smoking. While smokeless tobacco contains harmful and potentially harmful ...
  6. TSRC, Tob. Sci. Res. Conf., 2018, 72, abstr. 022

    Thermal profiling methods for the evaluation of electronic nicotine delivery systems (ENDS)

    ROGERS R.(1); SZABO D.T.(1); STRASSER J.(1); REYNOLDS C.(2)
    (1) RAI Services Company, Winston-Salem, NC, USA; (2) R.J. Reynolds Tobacco Company, Winston-Salem, NC, USA
    Electronic nicotine delivery systems (ENDS) contain tobacco-derived nicotine formulated in a liquid (“e-liquid”) typically consisting of glycerin, propylene glycol, water and flavoring ingredients. The e-liquid is aerosolized via a heating element in the ...
  7. TSRC, Tob. Sci. Res. Conf., 2018, 72, abstr. 066

    Distinct gene expression changes in peripheral blood mononuclear cells exposed to combustible versus non-combustible tobacco product preparations

    TRAN N.Q.(1); ARIMILLI S.(2); MADAHIAN B.(3); HOMAYOUNI R.(3); PRASAD G.L.(1)
    (1) RAI Services, Winston-Salem, NC, USA; (2) Wake Forest University, Winston-Salem, NC, USA; (3) Quire Inc., Memphis, TN, USA
    Cigarette smoking exerts diverse physiological effects including immune suppression. Existing epidemiological data show that consumption of smokeless tobacco products, such as moist snuff, is less harmful relative to smoking. We previously demonstrated ...
  8. TSRC, Tob. Sci. Res. Conf., 2018, 72, abstr. 072 (also presented at CORESTA 2018)

    FDA advance notice of proposed rulemaking for nicotine level of combusted cigarettes – feasibility for compliance via tobacco plant genetics?

    HIATT E.
    R.J. Reynolds Tobacco Company, Winston-Salem, NC, USA
    On March 16, 2018, the U.S. Food and Drug Administration (FDA) published an advance notice of proposed rulemaking (ANPRM) entitled “Tobacco Product Standard for Nicotine Level of Combusted Cigarettes.” The publication of an ANPRM solicits information and ...
  9. TSRC, Tob. Sci. Res. Conf., 2018, 72, abstr. 080

    Differential gene expression and functional responses in peripheral blood mononuclear cells pretreated with combustible and non-combustible tobacco products

    TRAN Q.T.(1); ARIMILLI S.(2); LIU Gang(1); MAKENA P.(1); PRASAD G.L.(1)
    (1) RAI Services Company, Winston-Salem, NC, USA; (2) Wake Forest School of Medicine, Winston-Salem, NC, USA
    Chronic smoking is known to alter immune responses, which compromises tumor surveillance and host defense against microbial infections. We previously showed that smokers (SMK) exhibit distinct peripheral blood mononuclear cell (PBMC) gene expression ...