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  1. CORESTA Meeting, Smoke Science/Product Technology, 2017, Kitzbühel, STPOST 19

    Combustible and smokeless tobacco product preparations differentially regulate calcium mobilization in the human leukemic HL60 cell line

    MAKENA P.(2); ARIMILLI S.(1); DAMRATOSKI B.E.(1); PRASAD G.L.(2)
    (1) Wake Forest University School of Medicine, Department of Microbiology & Immunology, Winston-Salem, NC, U.S.A.; (2) RAI Services Co., Winston-Salem, NC 27102, U.S.A.
    Increased calcium (Ca 2+) mobilization is central to leukocyte signaling and for regulation of immune responses. Although evidence suggests that cigarette smoking affects several biological functions including inflammatory responses, how the use of ...
  2. CORESTA Meeting, Smoke Science/Product Technology, 2011, Graz, ST 34

    Cytotoxic effects of different tobacco preparations on human peripheral blood mononeucleocytes

    ARIMILLI S.(1); DAMRATOSKI B.E.(1); PRASAD G.L.(2)
    (1) Dept. of Microbiology & Immunology, Wake Forest University School of Medicine, Winston-Salem, NC, USA; (2) R.J. Reynolds Tobacco Co., R&D, Winston-Salem, NC, USA
    Acute exposure to cigarette smoke or its components has been known to trigger diverse cellular effects, such as oxidative stress, DNA damage and cell death in a number of cell culture models. However, available data regarding the potential cytotoxic ...