Search Results

21 results

  1. CORESTA Congress, Edinburgh, 2010, SS 02; TSRC, Tob. Sci. Res. Conf., 2010, 64, abstr. 34

    A clinical trial of cardiovascular disease biomarkers in adult smokers and moist snuff consumers. Part I: study design, subject selection and cohort characterization

    JONES B.A.; BROWN B.G.; LEE L.C.; HEAVNER D.L.; STEICHEN T.J.; BORGERDING M.F.
    R.J. Reynolds Tobacco Company, R&D, Winston-Salem, NC, USA
    A single site, three cohort, age-stratified, cross-sectional study was conducted in the US in subjects who were exclusive cigarette smokers (n=60), exclusive moist snuff consumers (n=48), and non-consumers of tobacco (n=60) to identify potential CVD ...
  2. CORESTA Congress, Edinburgh, 2010, SS 03; TSRC, Tob. Sci. Res. Conf., 2010, 64, abstr. 35

    Cardiovascular disease biomarkers study, Part II: Tobacco-related biomarkers of exposure in exclusive cigarette smokers, exclusive moist snuff consumers, and non-consumers of tobacco.

    BROWN B.G.; JONES B.A.; LEE L.C.; HEAVNER D.L.; STEICHEN T.J.; BORGERDING M.F.
    R.J. Reynolds Tobacco Company, R&D, Winston-Salem, NC, USA
    A CVD biomarkers study conducted in the US measured putative tobacco-related biomarkers in three exclusive cohorts: cigarette smokers, moist snuff consumers and non-consumers of tobacco. Subjects were generally healthy males between the ages of 26-49. ...
  3. CORESTA Congress, Edinburgh, 2010, SS 04; TSRC, Tob. Sci. Res. Conf., 2010, 64, abstr. 36

    Cardiovascular disease biomarkers study, Part III: Tobacco-related biomarkers of effect in exclusive cigarette smokers, exclusive moist snuff consumers, and non-consumers of tobacco

    NORDSKOG B.K.; BROWN B.G.; JONES B.A.; HEAVNER D.L.; STEICHEN T.J.; BORGERDING M.F.
    R.J. Reynolds Tobacco Company, R&D, Winston-Salem, NC, USA
    A three cohort, age-stratified cross-sectional study was conducted in the U.S. in cigarette smokers (n=60), moist snuff consumers (n=48) and non-consumers of tobacco (n=60) to evaluate several known cardiovascular biomarkers of effect. Subject enrolment ...
  4. CORESTA Congress, Edinburgh, 2010, SSPT 04

    Differential exposure biomarker levels among non consumers of tobacco, consumers of oral tobacco products and cigarette smokers in the U.S. National Health & Nutrition Examination Survey 1999-2008

    WILSON C.L.; NAUFAL Z.S.; KATHMAN S.J.; MARANO K.M.
    R.J. Reynolds Tobacco Company, R&D, Bowman Gray Technical Center, Winston-Salem, NC, USA
    Consumer exposure to smokeless tobacco (SLT) and cigarette mainstream smoke (MSS) constituents depends primarily on the frequency, intensity, and duration of the consumer's exposure and on the chemical composition of the MSS or SLT product used. The ...
  5. CORESTA Congress, Edinburgh, 2010, SSPT 13; TSRC, Tob. Sci. Res. Conf., 2010, 64, abstr. 28

    Carbon-centered free radicals as intermediates to mainstream smoke carbonyls

    GERARDI A.R.; COLEMAN W.M. III
    R.J. Reynolds Tobacco Company, R&D, Winston-Salem, NC, USA
    Free radicals in cigarette smoke may contribute to harm associated with cigarette smoking, more specifically, contribute to oxidative stress and subsequent biological activity. A recent high throughput procedure for relative determination of 14 different ...
  6. CORESTA Congress, Edinburgh, 2010, SSPTPOST 13; TSRC, Tob. Sci. Res. Conf., 2010, 64, abstr. 08

    Clinical methodology and results for physiological assessments including flow-mediated dilation, carotid intima-media thickness, ankle brachial index, spirometry, and expired carbon monoxide in exclusive cigarette smokers, exclusive moist snuff consumers and non-consumers of tobacco

    BROWN B.G.; JONES B.A.; NORDSKOG B.K.; HEAVNER D.L.; STEICHEN T.J.; BORGERDING M.F.
    R.J. Reynolds Tobacco Company, R&D, Winston-Salem, NC, USA
    Several physiological assessments have been reported in the literature as measures for detecting, predicting and monitoring cardiovascular disease (CVD). These non-invasive techniques were investigated in three exclusive all male cohorts (cigarette ...
  7. CORESTA Congress, Edinburgh, 2010, SSPTPOST 22; TSRC, Tob. Sci. Res. Conf., 2010, 64, abstr. 07

    Gene expression analyses of the liver From ApoE-/- mice exposed to mainstream cigarette smoke

    NORDSKOG B.K.; CURTIN G.M.; BROWN J.E.; BOMBICK B.R.
    R.J. Reynolds Tobacco Company, R&D, Winston-Salem, NC, USA
    The goal of this study was to identify key molecular alterations induced by mainstream smoke exposure and diet in a genetically susceptible mouse model of atherosclerosis. ApoE-deficient female mice were exposed nose-only to mainstream cigarette smoke for ...
  8. CORESTA Congress, Edinburgh, 2010, SSPTPOST 24; TSRC, Tob. Sci. Res. Conf., 2010, 64, abstr. 10

    Standardization of the preparation of smokeless tobacco extracts for assessment of biological effects

    PRASAD G.L.; FOWLER K.; HILL J.A.; BOMBICK B.R.
    R.J. Reynolds Tobacco Company, R&D, Bowman Gray Technical Center, Winston-Salem, NC, USA
    Exposure to smokeless tobacco (ST) has been reported to elicit diverse biological effects at the cellular level. Currently, there is no consensus regarding parameters that will impact cellular response. Various conditions have been described for 1) ...