Search Results

89 results

  1. CORESTA Meeting, Smoke Science/Product Technology, 2019, Hamburg, ST 12

    Review of current methodologies in evaluating abuse liability of nicotine and tobacco products in the U.S. regulatory environment

    EVANS S.(1); KONG M.C.(2); CAMPBELL L.(2); SHERWOOD N.(3); PRASAD K.(4)
    (1) Turning Point Brands, Louisville, KY, U.S.A.; (2) Altasciences Clinical Research, Laval, Canada; (3) Neil Sherwood Consulting, Nyon, Switzerland; (4) British American Tobacco, R&D, Millbrook, Southampton, U.K.
    Traditional definitions of abuse and misuse do not apply to a consumer product such as tobacco that consumers essentially use ‘as intended’. In contrast to pharmaceutical products, a guidance for abuse liability testing of nicotine and tobacco...
  2. CORESTA Meeting, Smoke Science/Product Technology, 2019, Hamburg, ST 52 (also presented at TSRC 2019)

    Application of differential ion mobility spectrometry-tandem mass spectrometry for improved assay selectivity and sensitivity in the quantitation of tobacco biomarkers NNN, NNAL and 2-/3-HPMA in human urine

    PLOMLEY J.B.
    Altasciences, Laval, QC, Canada
    Differential ion mobility spectrometry (DMS) has recently emerged as an orthogonal gas-phase ion separation technique which, when interfaced between liquid chromatography (LC) and tandem mass spectrometry (MS/MS), promises improvements in both assay...
  3. CORESTA Meeting, Smoke Science/Product Technology, 2019, Hamburg, STPOST 58

    A consortium approach for consumer-reported outcome measures to assess tobacco- and nicotine-containing products

    ACQUADRO C.(1) on behalf of the CORESTA CROM Task Force: AYALA-FIERRO F.(2); BLACK R.(3); CAHOURS X.(4); CHREA C.(5); CURTIN G.(6); GILES L.(7); McCAFFREY S.(3); PARK C.H.(8); PRASAD K.(9); SHERWOOD N.(10); SHIFFMAN S.(11); SMITH J.(6); SPIES E.(5)
    (1) Mapi Research Trust, Lyon, France; (2) ITG Brands, Greensboro, NC, U.S.A.; (3) Altria Client Services, Richmond, VA, U.S.A.; (4) SEITA - Imperial Brands, Paris, France; (5) Philip Morris Products S.A., Neûchatel, Switzerland; (6) RAIS, Winston-Salem, NC, U.S.A.; (7) JT Int'l SA, Genève, Switzerland; (8) KT&G Research Institute, Daejeon, Republic of Korea; (9) British American Tobacco, Southampton, U.K.; (10) Neil Sherwood Consulting, Commugny, Switzerland; (11) Pinney Associates, Pittsburgh, PA, U.S.A.
    In the tobacco space, consumer-reported outcome measures (CROM) are essential for understanding motivations, subjective effects, and behavior. Such measures have become particularly important with the advent of candidate modified risk tobacco...
  4. TSRC, Tob. Sci. Res. Conf., 2019, 73, abstr. 044

    Abuse liability of very low nicotine content cigarettes with characterization of nicotine exposure profiles in adult smokers

    LEVY-COOPERMAN N.(1); SHRAM M.J.(1); KELSH D.(2); VINCE B.(2); CARMINES E.(3)
    (1) Altreos Research Partners, Toronto, ON, Canada; (2) Altasciences/Vince and Associates, Overland Park, KS, USA; (3) Carmines Consulting, Scottsdale, AZ, USA
    Objectives: In 2017, FDA announced the intention to explore limiting nicotine in cigarettes to minimal/non-addictive levels. Research indicates that reduced nicotine content would potentially limit reinforcing effects of cigarettes. We conducted 2...
  5. TSRC, Tob. Sci. Res. Conf., 2019, 73, abstr. 102 (also presented at CORESTA SSPT2019)

    Novel application of differential ion mobility spectrometry-tandem mass spectrometry for improved assay selectivity and sensitivity in the quantitative determination of total NNN total NNAL and 2- / 3-HPMA in human urine

    PLOMLEY J.
    Altasciences, Laval, Canada
    Differential Ion Mobility Spectrometry (DMS) has recently emerged as an orthogonal gas-phase ion separation technique which, when interfaced between liquid chromatography (LC) and Tandem Mass Spectrometry (MS/MS), promises improvements in both assay...
  6. CORESTA Congress, Kunming, 2018, Smoke Science/Product Technology Groups, ST 52 (also presented at TSRC 2018)also presented at TSRC 2018)

    Consumers’ perceptions of disease-specific modified-risk claims are best evaluated in a disease-specific manner

    SHIFFMAN S.(1); CURTIN G.(2)
    (1) Pinney Associates, Pittsburgh, PA, U.S.A.; (2) RAI Services Company, Winston-Salem, NC, U.S.A.
    Manufacturers seeking to make claims about modified-risk tobacco products (MRTPs) must assess consumers' perceptions of risk reduction for these products. Claims made for the MRTP and assessment of perceived risk reduction can be global (e.g....
  7. CORESTA Congress, Kunming, 2018, Smoke Science/Product Technology Groups, ST 53 (also presented at TSRC 2018)

    Comparing direct and indirect assessments of perceptions of reduced risk for a modified-risk tobacco product

    SHIFFMAN S.(1); CURTIN G.(2)
    (1) Pinney Associates, Pittsburgh, PA, U.S.A.; (2) RAI Services Company, Winston-Salem, NC, U.S.A.
    Manufacturers seeking to make claims about modified-risk tobacco products (MRTPs) must assess consumers' perceptions of absolute and relative risks for these products. We cross-validate data from two methods: (a) indirect assessments based on the...
  8. TSRC, Tob. Sci. Res. Conf., 2018, 72, abstr. 030

    Comparisons of dependence on cigarettes and e-cigarettes: data from the path study

    KIM M.M.(1); SHIFFMAN S.(2); SEMBOWER M.(2)
    (1) RAI Services Company, Winston-Salem, NC, USA; (2) PinneyAssociates, Inc., Pittsburgh, PA, USA
    An Item-Response-Theory-based dependence scale, developed on PATH data, assesses e-cigarette dependence, and for the first time allows for direct comparison of dependence across products. Data were from adult established users of e-cigarettes (ECIG)...
  9. TSRC, Tob. Sci. Res. Conf., 2018, 72, abstr. 031

    Use patterns and tobacco use histories among users of diverse vapor products: cigalikes, tanks, and other vapor products

    KIM M.M.(1); SHIFFMAN S.(2); SEMBOWER M.(2)
    (1) RAI Services Company, Winston-Salem, NC, USA; (2) PinneyAssociates, Inc., Pittsburgh, PA, USA
    There are several types of vapor products, but little research has characterized differences in their use or users. We examined the differences in use and characteristics of users of cigalikes, tanks, and other, 'variant' vapor products in a national...