Search Results

67 results

  1. CORESTA Meeting, Smoke Science/Product Technology, 2019, Hamburg, ST 18

    Human precision-cut lung slices as a screening tool: increased throughput, cryopreservation, and detection of DNA adducts for next generation tobacco product evaluation

    BEHRSING H.P.(1); DESAI P.(1); AMIN K.(2); BALBO S.(3); HECHT S.S.(2); SHEEHAN D.(1); CASTRO N.(1); ALLEN D.(4)
    (1) Institute for In Vitro Sciences, Inc., Gaithersburg, MD, U.S.A.; (2) University of Minnesota, Division of Environmental Health Sciences, Minneapolis, MN, U.S.A.; (3) University of Minnesota, Department of Laboratory Medicine and Pathology, Minneapolis, MN, U.S.A.; (4) Integrated Laboratory Systems, Inc., Morrisville, NC, U.S.A.
    Human-relevant, in vitro/ex vivo assays are considered an ethical and economically viable manner by which to screen the many chemicals requiring hazard assessment, such as next generation tobacco product (NGTP) ingredients. Human precision-cut lung slices ...
  2. CORESTA Meeting, Smoke Science/Product Technology, 2019, Hamburg, STPOST 36

    Use of ex vivo precision-cut lung slices as a screening tool for potential respiratory toxicity of e-liquids

    BEHRSING H.P.(1); SHEEHAN D.(1); AMIN K.(2); LEE K.M.(3); OLDHAM M.(4); RAABE H.(1)
    (1) Institute for In Vitro Sciences, Inc., Gaithersburg, MD, U.S.A.; (2) University of Minnesota, Minneapolis, MN, U.S.A.; (3) Altria Client Services, Richmond, VA, U.S.A.; (4) former Altria Client Services employee
    The Family Smoking Prevention and Tobacco Control Act gave the FDA regulatory authority over next generation tobacco products (NGTP) such as e-vapor products. E-vapor product liquids contain a variety of ingredient combinations that should be assessed for ...
  3. CORESTA Meeting, Smoke Science/Product Technology, 2019, Hamburg, STPOST 47

    Identification, discussion and recommendations for the optimal generation and use of in vitro genotoxicity assay data for tobacco and nicotine products

    DESAI P.(1); CURREN R.(1); MOORE M.M.(2)
    (1) Institute for In Vitro Sciences, Gaithersburg, MD, U.S.A.; (2) Ramboll Environ Inc., Little Rock, AR, U.S.A.
    The Institute for In Vitro Sciences is sponsoring a series of workshops to identify, discuss and develop recommendations for optimal scientific/technical approaches for utilizing in vitro regulatory genotoxicity assay data within and across tobacco and ...
  4. CORESTA Meeting, Smoke Science/Product Technology, 2019, Hamburg, STPOST 58

    A consortium approach for consumer-reported outcome measures to assess tobacco- and nicotine-containing products

    ACQUADRO C.(1) on behalf of the CORESTA CROM Task Force: AYALA-FIERRO F.(2); BLACK R.(3); CAHOURS X.(4); CHREA C.(5); CURTIN G.(6); GILES L.(7); McCAFFREY S.(3); PARK C.H.(8); PRASAD K.(9); SHERWOOD N.(10); SHIFFMAN S.(11); SMITH J.(6); SPIES E.(5)
    (1) Mapi Research Trust, Lyon, France; (2) ITG Brands, Greensboro, NC, U.S.A.; (3) Altria Client Services, Richmond, VA, U.S.A.; (4) SEITA - Imperial Brands, Paris, France; (5) Philip Morris Products S.A., Neûchatel, Switzerland; (6) RAIS, Winston-Salem, NC, U.S.A.; (7) JT Int'l SA, Genève, Switzerland; (8) KT&G Research Institute, Daejeon, Republic of Korea; (9) British American Tobacco, Southampton, U.K.; (10) Neil Sherwood Consulting, Commugny, Switzerland; (11) Pinney Associates, Pittsburgh, PA, U.S.A.
    In the tobacco space, consumer-reported outcome measures (CROM) are essential for understanding motivations, subjective effects, and behavior. Such measures have become particularly important with the advent of candidate modified risk tobacco products ...
  5. TSRC, Tob. Sci. Res. Conf., 2019, 73, abstr. 008

    Workshop series to identify, discuss and develop recommendations for the optimal generation and use of in vitro genotoxicity assay data for tobacco and nicotine products

    MOORE M.M.(1); CURREN R.(2)
    (1) Ramboll US Corporation, Little Rock, AR, USA; (2) Institute for In Vitro Sciences, Gaithersburg, MD, USA
    The Institute for In Vitro Sciences is sponsoring a series of workshops to identify, discuss and develop recommendations for optimal scientific/technical approaches for utilizing in vitro regulatory genotoxicity assay data within and across tobacco and ...
  6. CORESTA Congress, Kunming, 2018, Smoke Science/Product Technology Groups, ST 52 (also presented at TSRC 2018)also presented at TSRC 2018)

    Consumers’ perceptions of disease-specific modified-risk claims are best evaluated in a disease-specific manner

    SHIFFMAN S.(1); CURTIN G.(2)
    (1) Pinney Associates, Pittsburgh, PA, U.S.A.; (2) RAI Services Company, Winston-Salem, NC, U.S.A.
    Manufacturers seeking to make claims about modified-risk tobacco products (MRTPs) must assess consumers' perceptions of risk reduction for these products. Claims made for the MRTP and assessment of perceived risk reduction can be global (e.g. &quot ...
  7. CORESTA Congress, Kunming, 2018, Smoke Science/Product Technology Groups, ST 53 (also presented at TSRC 2018)

    Comparing direct and indirect assessments of perceptions of reduced risk for a modified-risk tobacco product

    SHIFFMAN S.(1); CURTIN G.(2)
    (1) Pinney Associates, Pittsburgh, PA, U.S.A.; (2) RAI Services Company, Winston-Salem, NC, U.S.A.
    Manufacturers seeking to make claims about modified-risk tobacco products (MRTPs) must assess consumers' perceptions of absolute and relative risks for these products. We cross-validate data from two methods: (a) indirect assessments based on the ...
  8. TSRC, Tob. Sci. Res. Conf., 2018, 72, abstr. 030

    Comparisons of dependence on cigarettes and e-cigarettes: data from the path study

    KIM M.M.(1); SHIFFMAN S.(2); SEMBOWER M.(2)
    (1) RAI Services Company, Winston-Salem, NC, USA; (2) PinneyAssociates, Inc., Pittsburgh, PA, USA
    An Item-Response-Theory-based dependence scale, developed on PATH data, assesses e-cigarette dependence, and for the first time allows for direct comparison of dependence across products. Data were from adult established users of e-cigarettes (ECIG) and ...
  9. TSRC, Tob. Sci. Res. Conf., 2018, 72, abstr. 031

    Use patterns and tobacco use histories among users of diverse vapor products: cigalikes, tanks, and other vapor products

    KIM M.M.(1); SHIFFMAN S.(2); SEMBOWER M.(2)
    (1) RAI Services Company, Winston-Salem, NC, USA; (2) PinneyAssociates, Inc., Pittsburgh, PA, USA
    There are several types of vapor products, but little research has characterized differences in their use or users. We examined the differences in use and characteristics of users of cigalikes, tanks, and other, 'variant' vapor products in a ...