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22 results

  1. CORESTA Congress, Online, 2022, Smoke Science/Product Technology Groups, ST 54

    Comparison of heated tobacco product aerosol to cigarette smoke in human bronchial epithelial tissues using high content screening

    TRELLES STICKEN E.(1); WIECZOREK R.(1); POUR S.J.(1); CHAPMAN F.(2); SIMMS L.(2); STEVENSON M.(2)
    (1) Reemtsma Cigarettenfabriken GmbH, Hamburg, Germany; (2) Imperial Brands PLC, Bristol U.K.
    Laboratory studies have shown heated tobacco product (HTP) aerosols have substantially reduced numbers and levels of harmful and potentially harmful constituents (HPHCs) relative to combustible cigarette smoke. The biological impact of these aerosols...
  2. CORESTA Congress, Online, 2020, Smoke Science/Product Technology Groups, ST 03

    Method development for the analysis of mono-carbonyl compounds in e-vapor products by LC-MS

    ZHU J.; HEREDIA A.; TWEEDY J.; TAYYARAH R.
    ITG Brands and Fontem USA, Greensboro, NC, U.S.A.
    At the 73rd Tobacco Science Research Conference (TSRC), we presented a novel method for quantitation by LC-MS of mono-carbonyl compounds in e-vapor product aerosol samples. The method is simple and robust with good recoveries. We have since extended...
  3. CORESTA Congress, Kunming, 2018, Smoke Science/Product Technology Groups, ST 25

    Misperception of e-cigarette harm growing among American adults, 2013-2015

    VERRON T.(1); GUO M.(1); VARIGNON B.(1); O'CONNELL G.(2); WALELE T.(2); CAHOURS X.(1)
    (1) SEITA - Imperial Brands plc, Paris, France; (2) Fontem Ventures B.V., Amsterdam, The Netherlands
    Electronic cigarettes (e cigarettes) have been characterised as significantly less harmful than smoked tobacco by an increasing number of public health authorities. However, the proportion of American adults who perceive e cigarettes to be equally or...
  4. CORESTA Congress, Kunming, 2018, Smoke Science/Product Technology Groups, ST 59

    An inter-laboratory comparison study focused on the determination of total NNAL in human urine

    NEWLAND K.(1); SCHERER M.(2); HECHT S.S.(3); TROUDE V.(4); PRASAD G.L.(5)
    (1) Celerion Inc., Lincoln, NE, U.S.A.; (2) ABF GmbH, Planegg, Germany; (3) University of Minnesota Cancer Center, Minneapolis, MN, U.S.A.; (4) Reemtsma Cigarettenfabriken GmbH, Imperial Brands plc, Hamburg, Germany; (5) RAI Services Company, Winston-Salem, NC, U.S.A.
    In an ongoing effort to fulfil the second objective of the CORESTA Biomarker Sub-Group, periodic inter-laboratory comparison studies have been performed to evaluate the consistency of the quantitation for various harmful or potentially harmful...
  5. CORESTA Congress, Kunming, 2018, Smoke Science/Product Technology Groups, STPOST 52

    Biological test procedure for fresh generated cigarette smoke and e-cigarette aerosols under air-liquid interface (ALI) exposure in 24 and 96 multi-well plates

    WIECZOREK R.(1); TRELLES STICKEN E.(1); WALELE T.(2); CZEKALA L.(3); SIMMS L.(3)
    (1) Reemtsma Cigarettenfabriken GmbH, Imperial Brands plc, Hamburg, Germany; (2) Fontem Ventures, Amsterdam, The Netherlands; (3) Imperial Tobacco Limited, Bristol, U.K.
    Cigarette smoke and e cigarette aerosol contain particulate matter/liquid droplets in the solid phase as well as volatile substances in the gas phase. Both fractions are of potential toxicological relevance and should be considered when assessing...
  6. CORESTA Congress, Kunming, 2018, Smoke Science/Product Technology Groups, STPOST 53

    Use of human derived cell lines to increase the biological relevance of cigarette condensate, non-tobacco materials and e-liquids testing

    WIECZOREK R.(1); TRELLES STICKEN E.(1); WALELE T.(2); CZEKALA L.(3); SIMMS L.(3)
    (1) Reemtsma Cigarettenfabriken GmbH, Imperial Brands plc, Hamburg, Germany; (2) Fontem Ventures, Amsterdam, The Netherlands; (3) Imperial Tobacco Limited, Bristol, U.K.
    The in vitro testing strategy of tobacco products is mainly based on the testing of extracts from cigarette smoke condensates. An accepted industry wide assay battery has been developed over recent years which delivers reliable results for the...
  7. CORESTA Meeting, Smoke Science/Product Technology, 2017, Kitzbühel, ST 22

    Estimation of e-cigarette aerosol yields based on puff duration

    JULIEN R.(1); TSCHIERSKE N.(2); VARIGNON B.(1); TROUDE V.(1); DESTRUHAUT S.(1); WALELE T.(3); COLARD S.(1); CAHOURS X.(1)
    (1) SEITA-Imperial Tobacco Limited, Fleury-les-Aubrais, France; (2) Reemtsma Cigarettenfabriken GmbH (an Imperial Brands PLC Company), Hamburg, Germany; (3) Fontem Ventures B.V. (an Imperial Brands PLC Company), Amsterdam, The Netherlands
    There are regulatory requirements in quantifying and comparing the emission levels of major and minor aerosol constituents from e-cigarettes. Up until the recent publication in 2015 of CORESTA Recommended Method (CRM) No. 81 - "Routine Analytical...
  8. CORESTA Meeting, Smoke Science/Product Technology, 2017, Kitzbühel, ST 62

    Overview of in vitro methods used to assess e-cigarettes based on “Toxicity Testing in 21st Century” principles

    SIMMS L.(1); STEVENSON M.(1); CZEKALA L.(1); TSCHIERSKE N.(1); WALELE T.(2)
    (1) Imperial Tobacco Ltd, Bristol, U.K.; (2) Fontem Ventures B.V. (an Imperial Brands PLC Company), Amsterdam, The Netherlands
    When the National Academies of Sciences released “Toxicity Testing in the 21st Century: A Vision and a Strategy” a new toxicological paradigm was created, focusing on the use of human cell lines and the disruption of key cellular pathways. In keeping...
  9. CORESTA Meeting, Smoke Science/Product Technology, 2017, Kitzbühel, STPOST 07

    Consistency of bluTM e-cigarette nicotine delivery according to the AFNOR standard

    TSCHIERSKE N.(1); JULIEN R.(2); VARIGNON B.(2); TROUDE V.(2); DESTRUHAUT S.(2); WALELE T.(3); COLARD S.(2); CAHOURS X.(2)
    (1) Reemtsma Cigarettenfabriken GmbH (an Imperial Brands PLC Company), Hamburg, Germany; (2) SEITA-Imperial Tobacco Limited, Fleury-les-Aubrais, France; (3) Fontem Ventures B.V. (an Imperial Brands PLC Company), Amsterdam, The Netherlands
    Demonstrating the consistency of nicotine delivery from an e-cigarette is a requirement per EU Tobacco Product Directive (TPD) 2, Article 20, 3(f) (The European Council and the Council of the European Union, 2014). The Directive states that...
  10. CORESTA Meeting, Smoke Science/Product Technology, 2017, Kitzbühel, STPOST 08

    Indoor air quality and surface deposition assessment following use of an open system e-cigarette

    BAUER N.(1); TSCHIERSKE N.(1); O'CONNELL G.(2); CAHOURS X.(3)
    (1) Reemtsma Cigarettenfabriken GmbH (an Imperial Brands PLC Company), Hamburg, Germany; (2) Fontem Ventures B.V. (an Imperial Brands PLC Company), Amsterdam, The Netherlands; (3) SEITA-Imperial Tobacco Limited, Fleury-les-Aubrais, France
    Electronic cigarette (e-cigarette) nicotine delivery devices are growing in popularity worldwide. Both regulators and public health organisations are beginning to examine potential implications that exposure to exhaled e-cigarette aerosol may have on...